POSSIBILITIES OF VACUUM-INSTILLATION THERAPY WITH DIMEXIDUM AND BETADINE IN THE TREATMENT OF PURULENT WOUNDS

With the use of vacuum therapy in the treatment of purulent wounds, it is not possible to actively localize the microflora in the wound, since the last is for a long time covered by an insulating sealed bandage. In addition, unlike with traditional methods of treating wounds with daily dressings, th...

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Autores principales:	E. V. Razmakhnin, V. A. Shangin, O. G. Kudryavtseva, D. Y. Okhlopkov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	injury wound infection vacuum therapy cytokines Science Q
Acceso en línea:	https://doaj.org/article/1e4ceabc6c2d4aa7963ddbb0ab8cd70e
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spelling	oai:doaj.org-article:1e4ceabc6c2d4aa7963ddbb0ab8cd70e2021-11-23T06:14:39ZPOSSIBILITIES OF VACUUM-INSTILLATION THERAPY WITH DIMEXIDUM AND BETADINE IN THE TREATMENT OF PURULENT WOUNDS2541-94202587-959610.12737/article_5a0a8e0d03dc42.56682733https://doaj.org/article/1e4ceabc6c2d4aa7963ddbb0ab8cd70e2017-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/488https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596With the use of vacuum therapy in the treatment of purulent wounds, it is not possible to actively localize the microflora in the wound, since the last is for a long time covered by an insulating sealed bandage. In addition, unlike with traditional methods of treating wounds with daily dressings, there is no effect of "washing away" detritus, necrotic masses, accumulations of leukocytes. The aim of the work was to develop a technique for vacuum-instillation therapy of wounds using dimexidum and betadine and to evaluate its effectiveness in comparison with the isolated application of controlled negative pressure in patients with purulent wounds of various origins. 58 patients with chronic purulent wounds, trophic ulcers with atherosclerotic lesions of the vessels of the extremities and diabetic angiopathy were examined. The first group of patients received isolated vacuum therapy, the second group was managed with vacuum-instillation therapy with dimexidum and betadine, the control group received traditional treatment with water-soluble ointments. Evaluation of the results of treatment was based on growth of granulation tissue, reduction of defect size, and level of cytokines in traumatic discharge. Vacuum therapy significantly improves the course of the wound process, which leads to faster cleaning, granulation of the defect and a decrease in its size. When added to NPWT instillations of antiseptics, anti-inflammatory, antioxidant and anabolic effects are enhanced, which facilitates more pronounced regenerative response and, accordingly, a reduction in the duration of treatment.E. V. RazmakhninV. A. ShanginO. G. KudryavtsevaD. Y. OkhlopkovScientific Сentre for Family Health and Human Reproduction Problemsarticleinjurywound infectionvacuum therapycytokinesScienceQRUActa Biomedica Scientifica, Vol 2, Iss 6, Pp 153-156 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	injury wound infection vacuum therapy cytokines Science Q
spellingShingle	injury wound infection vacuum therapy cytokines Science Q E. V. Razmakhnin V. A. Shangin O. G. Kudryavtseva D. Y. Okhlopkov POSSIBILITIES OF VACUUM-INSTILLATION THERAPY WITH DIMEXIDUM AND BETADINE IN THE TREATMENT OF PURULENT WOUNDS
description	With the use of vacuum therapy in the treatment of purulent wounds, it is not possible to actively localize the microflora in the wound, since the last is for a long time covered by an insulating sealed bandage. In addition, unlike with traditional methods of treating wounds with daily dressings, there is no effect of "washing away" detritus, necrotic masses, accumulations of leukocytes. The aim of the work was to develop a technique for vacuum-instillation therapy of wounds using dimexidum and betadine and to evaluate its effectiveness in comparison with the isolated application of controlled negative pressure in patients with purulent wounds of various origins. 58 patients with chronic purulent wounds, trophic ulcers with atherosclerotic lesions of the vessels of the extremities and diabetic angiopathy were examined. The first group of patients received isolated vacuum therapy, the second group was managed with vacuum-instillation therapy with dimexidum and betadine, the control group received traditional treatment with water-soluble ointments. Evaluation of the results of treatment was based on growth of granulation tissue, reduction of defect size, and level of cytokines in traumatic discharge. Vacuum therapy significantly improves the course of the wound process, which leads to faster cleaning, granulation of the defect and a decrease in its size. When added to NPWT instillations of antiseptics, anti-inflammatory, antioxidant and anabolic effects are enhanced, which facilitates more pronounced regenerative response and, accordingly, a reduction in the duration of treatment.
format	article
author	E. V. Razmakhnin V. A. Shangin O. G. Kudryavtseva D. Y. Okhlopkov
author_facet	E. V. Razmakhnin V. A. Shangin O. G. Kudryavtseva D. Y. Okhlopkov
author_sort	E. V. Razmakhnin
title	POSSIBILITIES OF VACUUM-INSTILLATION THERAPY WITH DIMEXIDUM AND BETADINE IN THE TREATMENT OF PURULENT WOUNDS
title_short	POSSIBILITIES OF VACUUM-INSTILLATION THERAPY WITH DIMEXIDUM AND BETADINE IN THE TREATMENT OF PURULENT WOUNDS
title_full	POSSIBILITIES OF VACUUM-INSTILLATION THERAPY WITH DIMEXIDUM AND BETADINE IN THE TREATMENT OF PURULENT WOUNDS
title_fullStr	POSSIBILITIES OF VACUUM-INSTILLATION THERAPY WITH DIMEXIDUM AND BETADINE IN THE TREATMENT OF PURULENT WOUNDS
title_full_unstemmed	POSSIBILITIES OF VACUUM-INSTILLATION THERAPY WITH DIMEXIDUM AND BETADINE IN THE TREATMENT OF PURULENT WOUNDS
title_sort	possibilities of vacuum-instillation therapy with dimexidum and betadine in the treatment of purulent wounds
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/1e4ceabc6c2d4aa7963ddbb0ab8cd70e
work_keys_str_mv	AT evrazmakhnin possibilitiesofvacuuminstillationtherapywithdimexidumandbetadineinthetreatmentofpurulentwounds AT vashangin possibilitiesofvacuuminstillationtherapywithdimexidumandbetadineinthetreatmentofpurulentwounds AT ogkudryavtseva possibilitiesofvacuuminstillationtherapywithdimexidumandbetadineinthetreatmentofpurulentwounds AT dyokhlopkov possibilitiesofvacuuminstillationtherapywithdimexidumandbetadineinthetreatmentofpurulentwounds
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POSSIBILITIES OF VACUUM-INSTILLATION THERAPY WITH DIMEXIDUM AND BETADINE IN THE TREATMENT OF PURULENT WOUNDS

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