Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics
Purpose: To evaluate the dependence of biomechanical metrics on intraocular pressure (IOP).Methods: 233 refractive surgery patients were included in this study—all were examined 3 times with the Corvis ST before and after dilation, and the differences (∆) in the main device parameters were assessed....
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Frontiers Media S.A.
2021
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oai:doaj.org-article:1e4d148cd0884a9a8be83e25e7fcbb692021-12-01T08:34:27ZEffect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics2296-418510.3389/fbioe.2021.751628https://doaj.org/article/1e4d148cd0884a9a8be83e25e7fcbb692021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.751628/fullhttps://doaj.org/toc/2296-4185Purpose: To evaluate the dependence of biomechanical metrics on intraocular pressure (IOP).Methods: 233 refractive surgery patients were included in this study—all were examined 3 times with the Corvis ST before and after dilation, and the differences (∆) in the main device parameters were assessed. The data collected included the biomechanically corrected IOP (bIOP), the central corneal thickness (CCT), and six dynamic corneal response (DCR) parameters, namely DA, DARatio2mm, IIR, SP-A1, CBI, and SSI. Participants were divided into three groups according to the changes in patients’ bIOP after mydriasis.Results: Intra-operator repeatability was generally high in most of the DCR parameters obtained before and after dilation. The mean changes in bIOP and CCT after dilation were −0.12 ± 1.36 mmHg and 1.95 ± 5.23 μm, respectively. Only ∆DARatio2mm, ∆IIR, and ∆CBI exhibited a statistically significant correlation with ∆CCT (p < 0.05). The changes in all DCR parameters, especially ∆DA and ∆SP-A1 were also correlated with ∆bIOP (p < 0.01)—a 1-mmHg change in bIOP was associated, on average, with 5.612 and −0.037 units of change in SP-A1 and DA, respectively. In contrast, the weakest correlation with ∆bIOP was exhibited by ∆SSI.Conclusion: Most corneal DCR parameters, provided by the Corvis ST, were correlated with IOP, and more weakly with CCT. Changes experienced in CCT and IOP should therefore be considered in studies on corneal biomechanics and how it is affected by disease progression and surgical or medical procedures.Yufeng YeYi LiZehui ZhuAnas Ziad Masoud Abu SaidKevin Nguelemo MayopaStephen AkitiChengyi HuangBernardo T. LopesAshkan EliasyYuanyuan MiaoJunjie WangJunjie WangXiaobo ZhengXiaobo ZhengShihao ChenShihao ChenFangjun BaoFangjun BaoAhmed ElsheikhAhmed ElsheikhAhmed ElsheikhFrontiers Media S.A.articlebiomechanical metricsintraocular pressuremydriasisstiffness parameter at first applanationstress-strain indexBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021) |
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EN |
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biomechanical metrics intraocular pressure mydriasis stiffness parameter at first applanation stress-strain index Biotechnology TP248.13-248.65 |
| spellingShingle |
biomechanical metrics intraocular pressure mydriasis stiffness parameter at first applanation stress-strain index Biotechnology TP248.13-248.65 Yufeng Ye Yi Li Zehui Zhu Anas Ziad Masoud Abu Said Kevin Nguelemo Mayopa Stephen Akiti Chengyi Huang Bernardo T. Lopes Ashkan Eliasy Yuanyuan Miao Junjie Wang Junjie Wang Xiaobo Zheng Xiaobo Zheng Shihao Chen Shihao Chen Fangjun Bao Fangjun Bao Ahmed Elsheikh Ahmed Elsheikh Ahmed Elsheikh Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics |
| description |
Purpose: To evaluate the dependence of biomechanical metrics on intraocular pressure (IOP).Methods: 233 refractive surgery patients were included in this study—all were examined 3 times with the Corvis ST before and after dilation, and the differences (∆) in the main device parameters were assessed. The data collected included the biomechanically corrected IOP (bIOP), the central corneal thickness (CCT), and six dynamic corneal response (DCR) parameters, namely DA, DARatio2mm, IIR, SP-A1, CBI, and SSI. Participants were divided into three groups according to the changes in patients’ bIOP after mydriasis.Results: Intra-operator repeatability was generally high in most of the DCR parameters obtained before and after dilation. The mean changes in bIOP and CCT after dilation were −0.12 ± 1.36 mmHg and 1.95 ± 5.23 μm, respectively. Only ∆DARatio2mm, ∆IIR, and ∆CBI exhibited a statistically significant correlation with ∆CCT (p < 0.05). The changes in all DCR parameters, especially ∆DA and ∆SP-A1 were also correlated with ∆bIOP (p < 0.01)—a 1-mmHg change in bIOP was associated, on average, with 5.612 and −0.037 units of change in SP-A1 and DA, respectively. In contrast, the weakest correlation with ∆bIOP was exhibited by ∆SSI.Conclusion: Most corneal DCR parameters, provided by the Corvis ST, were correlated with IOP, and more weakly with CCT. Changes experienced in CCT and IOP should therefore be considered in studies on corneal biomechanics and how it is affected by disease progression and surgical or medical procedures. |
| format |
article |
| author |
Yufeng Ye Yi Li Zehui Zhu Anas Ziad Masoud Abu Said Kevin Nguelemo Mayopa Stephen Akiti Chengyi Huang Bernardo T. Lopes Ashkan Eliasy Yuanyuan Miao Junjie Wang Junjie Wang Xiaobo Zheng Xiaobo Zheng Shihao Chen Shihao Chen Fangjun Bao Fangjun Bao Ahmed Elsheikh Ahmed Elsheikh Ahmed Elsheikh |
| author_facet |
Yufeng Ye Yi Li Zehui Zhu Anas Ziad Masoud Abu Said Kevin Nguelemo Mayopa Stephen Akiti Chengyi Huang Bernardo T. Lopes Ashkan Eliasy Yuanyuan Miao Junjie Wang Junjie Wang Xiaobo Zheng Xiaobo Zheng Shihao Chen Shihao Chen Fangjun Bao Fangjun Bao Ahmed Elsheikh Ahmed Elsheikh Ahmed Elsheikh |
| author_sort |
Yufeng Ye |
| title |
Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics |
| title_short |
Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics |
| title_full |
Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics |
| title_fullStr |
Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics |
| title_full_unstemmed |
Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics |
| title_sort |
effect of mydriasis-caused intraocular pressure changes on corneal biomechanical metrics |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/1e4d148cd0884a9a8be83e25e7fcbb69 |
| work_keys_str_mv |
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