Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations

Abstract Genistein is applied worldwide as an alternative medicament for psoriasis (Ps) because of its anti-inflammatory activity and perceived beneficial impact on the skin. Hereby, we report our in vivo and in vitro investigations to supplement scientific research in this area. The reduction of cl...

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Autores principales:	Katarzyna Bocheńska, Marta Moskot, Elwira Smolińska-Fijołek, Joanna Jakóbkiewicz-Banecka, Aneta Szczerkowska-Dobosz, Bartosz Słomiński, Magdalena Gabig-Cimińska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e4d4b3052644340b8d850eb347a94f7
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spelling	oai:doaj.org-article:1e4d4b3052644340b8d850eb347a94f72021-12-02T18:02:15ZImpact of isoflavone genistein on psoriasis in in vivo and in vitro investigations10.1038/s41598-021-97793-42045-2322https://doaj.org/article/1e4d4b3052644340b8d850eb347a94f72021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97793-4https://doaj.org/toc/2045-2322Abstract Genistein is applied worldwide as an alternative medicament for psoriasis (Ps) because of its anti-inflammatory activity and perceived beneficial impact on the skin. Hereby, we report our in vivo and in vitro investigations to supplement scientific research in this area. The reduction of clinical and biochemical scores in mild to moderate Ps patients taking genistein, its safety, good tolerability with no serious adverse events or discontinuations of treatment, no dose-limiting toxicities, negligible changes in pharmacodynamic parameters and remarkable serum interleukin level alterations were documented in this study. A certain regression of the Ps phenotype was visible, based on photo-documented Ps lesion evaluation. Through in vitro experiments, we found that genistein reduced IL-17A and TNF-α induced MAPK, NF-κB, and PI3K activation in normal human epidermal keratinocytes. Moreover, at the mRNA level of genes associated with the early inflammatory response characteristic for Ps (CAMP, CCL20, DEFB4A, PIK3CA, S100A7, and S100A9) and key cellular signalling (MTORC1 and TFEB), we showed that this isoflavone attenuated the increased response of IL-17A- and TNF-α-related pathways. This allows us to conclude that genistein is a good candidate for Ps treatment, being attractive for co-pharmacotherapy with other drugs.Katarzyna BocheńskaMarta MoskotElwira Smolińska-FijołekJoanna Jakóbkiewicz-BaneckaAneta Szczerkowska-DoboszBartosz SłomińskiMagdalena Gabig-CimińskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katarzyna Bocheńska Marta Moskot Elwira Smolińska-Fijołek Joanna Jakóbkiewicz-Banecka Aneta Szczerkowska-Dobosz Bartosz Słomiński Magdalena Gabig-Cimińska Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
description	Abstract Genistein is applied worldwide as an alternative medicament for psoriasis (Ps) because of its anti-inflammatory activity and perceived beneficial impact on the skin. Hereby, we report our in vivo and in vitro investigations to supplement scientific research in this area. The reduction of clinical and biochemical scores in mild to moderate Ps patients taking genistein, its safety, good tolerability with no serious adverse events or discontinuations of treatment, no dose-limiting toxicities, negligible changes in pharmacodynamic parameters and remarkable serum interleukin level alterations were documented in this study. A certain regression of the Ps phenotype was visible, based on photo-documented Ps lesion evaluation. Through in vitro experiments, we found that genistein reduced IL-17A and TNF-α induced MAPK, NF-κB, and PI3K activation in normal human epidermal keratinocytes. Moreover, at the mRNA level of genes associated with the early inflammatory response characteristic for Ps (CAMP, CCL20, DEFB4A, PIK3CA, S100A7, and S100A9) and key cellular signalling (MTORC1 and TFEB), we showed that this isoflavone attenuated the increased response of IL-17A- and TNF-α-related pathways. This allows us to conclude that genistein is a good candidate for Ps treatment, being attractive for co-pharmacotherapy with other drugs.
format	article
author	Katarzyna Bocheńska Marta Moskot Elwira Smolińska-Fijołek Joanna Jakóbkiewicz-Banecka Aneta Szczerkowska-Dobosz Bartosz Słomiński Magdalena Gabig-Cimińska
author_facet	Katarzyna Bocheńska Marta Moskot Elwira Smolińska-Fijołek Joanna Jakóbkiewicz-Banecka Aneta Szczerkowska-Dobosz Bartosz Słomiński Magdalena Gabig-Cimińska
author_sort	Katarzyna Bocheńska
title	Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
title_short	Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
title_full	Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
title_fullStr	Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
title_full_unstemmed	Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
title_sort	impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1e4d4b3052644340b8d850eb347a94f7
work_keys_str_mv	AT katarzynabochenska impactofisoflavonegenisteinonpsoriasisininvivoandinvitroinvestigations AT martamoskot impactofisoflavonegenisteinonpsoriasisininvivoandinvitroinvestigations AT elwirasmolinskafijołek impactofisoflavonegenisteinonpsoriasisininvivoandinvitroinvestigations AT joannajakobkiewiczbanecka impactofisoflavonegenisteinonpsoriasisininvivoandinvitroinvestigations AT anetaszczerkowskadobosz impactofisoflavonegenisteinonpsoriasisininvivoandinvitroinvestigations AT bartoszsłominski impactofisoflavonegenisteinonpsoriasisininvivoandinvitroinvestigations AT magdalenagabigciminska impactofisoflavonegenisteinonpsoriasisininvivoandinvitroinvestigations
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Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations

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