Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation

Aβ plaques have been detected in brains of patients with prion diseases. Here, using mice, the authors show that prion infection enhances Aβ production via a PDK1-TACE mechanism and that brain deposition of Aβ induced by Aβ seeds co-transmitted with PrPSc contributes to mortality in prion disease....

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Autores principales:	Juliette Ezpeleta, Vincent Baudouin, Zaira E. Arellano-Anaya, François Boudet-Devaud, Mathéa Pietri, Anne Baudry, Anne-Marie Haeberlé, Yannick Bailly, Odile Kellermann, Jean-Marie Launay, Benoit Schneider
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e4e707388e247a5aac2217f5c04838e
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spelling	oai:doaj.org-article:1e4e707388e247a5aac2217f5c04838e2021-12-02T16:57:07ZProduction of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation10.1038/s41467-019-11333-32041-1723https://doaj.org/article/1e4e707388e247a5aac2217f5c04838e2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11333-3https://doaj.org/toc/2041-1723Aβ plaques have been detected in brains of patients with prion diseases. Here, using mice, the authors show that prion infection enhances Aβ production via a PDK1-TACE mechanism and that brain deposition of Aβ induced by Aβ seeds co-transmitted with PrPSc contributes to mortality in prion disease.Juliette EzpeletaVincent BaudouinZaira E. Arellano-AnayaFrançois Boudet-DevaudMathéa PietriAnne BaudryAnne-Marie HaeberléYannick BaillyOdile KellermannJean-Marie LaunayBenoit SchneiderNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juliette Ezpeleta Vincent Baudouin Zaira E. Arellano-Anaya François Boudet-Devaud Mathéa Pietri Anne Baudry Anne-Marie Haeberlé Yannick Bailly Odile Kellermann Jean-Marie Launay Benoit Schneider Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation
description	Aβ plaques have been detected in brains of patients with prion diseases. Here, using mice, the authors show that prion infection enhances Aβ production via a PDK1-TACE mechanism and that brain deposition of Aβ induced by Aβ seeds co-transmitted with PrPSc contributes to mortality in prion disease.
format	article
author	Juliette Ezpeleta Vincent Baudouin Zaira E. Arellano-Anaya François Boudet-Devaud Mathéa Pietri Anne Baudry Anne-Marie Haeberlé Yannick Bailly Odile Kellermann Jean-Marie Launay Benoit Schneider
author_facet	Juliette Ezpeleta Vincent Baudouin Zaira E. Arellano-Anaya François Boudet-Devaud Mathéa Pietri Anne Baudry Anne-Marie Haeberlé Yannick Bailly Odile Kellermann Jean-Marie Launay Benoit Schneider
author_sort	Juliette Ezpeleta
title	Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation
title_short	Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation
title_full	Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation
title_fullStr	Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation
title_full_unstemmed	Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation
title_sort	production of seedable amyloid-β peptides in model of prion diseases upon prpsc-induced pdk1 overactivation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1e4e707388e247a5aac2217f5c04838e
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Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation

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