Blocking negative effects of senescence in human skin fibroblasts with a plant extract
Skin aging: Plant extract blocks negative effects of senescence A plant extract from the goldenrod (Solidago virgaurea) ameliorates the negative influence of senescent cells, which accumulate in the skin with aging and create a tissue environment that leads to an impaired skin structure and contribu...
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Nature Portfolio
2018
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oai:doaj.org-article:1e51e56bcd8c4ecab59c13e58909e43a2021-12-02T13:41:45ZBlocking negative effects of senescence in human skin fibroblasts with a plant extract10.1038/s41514-018-0023-52056-3973https://doaj.org/article/1e51e56bcd8c4ecab59c13e58909e43a2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41514-018-0023-5https://doaj.org/toc/2056-3973Skin aging: Plant extract blocks negative effects of senescence A plant extract from the goldenrod (Solidago virgaurea) ameliorates the negative influence of senescent cells, which accumulate in the skin with aging and create a tissue environment that leads to an impaired skin structure and contributes to tumour formation. Ingo Lämmermann and a team of scientists under the lead of Johannes Grillari at the University of Natural Resources and Life Sciences, Vienna, Austria, screened several plant extracts for their potential to attenuate such detrimental effects of senescent cells on the skin. One extract from S. virgaurea indeed delayed the aging process of skin cells in vitro and reduced the secretion of tumour promoting molecules and pro-inflammatory factors, thereby ameliorating the negative influence on nearby cells. Thus, the investigated plant extract represents a promising possibility to block the age-associated loss of tissue functionality in human skin.Ingo LämmermannLucia Terlecki-ZaniewiczRegina WeinmüllnerMarkus SchossererHanna DellagoAndré Dargen de Matos BrancoDominik AutheriedBenjamin SevcnikarLisa KleisslIrina BerlinFrédérique MorizotFrancois LejeuneNicola FuzzatiSandra ForestierAlix ToribioAnaïs TromeurLionel WeinbergJuan Carlos Higareda AlmarazMarcel ScheidelerMarion RietveldAbdoel El GhalbzouriErwin TschachlerFlorian GruberJohannes GrillariNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-10 (2018) |
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DOAJ |
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Geriatrics RC952-954.6 |
| spellingShingle |
Geriatrics RC952-954.6 Ingo Lämmermann Lucia Terlecki-Zaniewicz Regina Weinmüllner Markus Schosserer Hanna Dellago André Dargen de Matos Branco Dominik Autheried Benjamin Sevcnikar Lisa Kleissl Irina Berlin Frédérique Morizot Francois Lejeune Nicola Fuzzati Sandra Forestier Alix Toribio Anaïs Tromeur Lionel Weinberg Juan Carlos Higareda Almaraz Marcel Scheideler Marion Rietveld Abdoel El Ghalbzouri Erwin Tschachler Florian Gruber Johannes Grillari Blocking negative effects of senescence in human skin fibroblasts with a plant extract |
| description |
Skin aging: Plant extract blocks negative effects of senescence A plant extract from the goldenrod (Solidago virgaurea) ameliorates the negative influence of senescent cells, which accumulate in the skin with aging and create a tissue environment that leads to an impaired skin structure and contributes to tumour formation. Ingo Lämmermann and a team of scientists under the lead of Johannes Grillari at the University of Natural Resources and Life Sciences, Vienna, Austria, screened several plant extracts for their potential to attenuate such detrimental effects of senescent cells on the skin. One extract from S. virgaurea indeed delayed the aging process of skin cells in vitro and reduced the secretion of tumour promoting molecules and pro-inflammatory factors, thereby ameliorating the negative influence on nearby cells. Thus, the investigated plant extract represents a promising possibility to block the age-associated loss of tissue functionality in human skin. |
| format |
article |
| author |
Ingo Lämmermann Lucia Terlecki-Zaniewicz Regina Weinmüllner Markus Schosserer Hanna Dellago André Dargen de Matos Branco Dominik Autheried Benjamin Sevcnikar Lisa Kleissl Irina Berlin Frédérique Morizot Francois Lejeune Nicola Fuzzati Sandra Forestier Alix Toribio Anaïs Tromeur Lionel Weinberg Juan Carlos Higareda Almaraz Marcel Scheideler Marion Rietveld Abdoel El Ghalbzouri Erwin Tschachler Florian Gruber Johannes Grillari |
| author_facet |
Ingo Lämmermann Lucia Terlecki-Zaniewicz Regina Weinmüllner Markus Schosserer Hanna Dellago André Dargen de Matos Branco Dominik Autheried Benjamin Sevcnikar Lisa Kleissl Irina Berlin Frédérique Morizot Francois Lejeune Nicola Fuzzati Sandra Forestier Alix Toribio Anaïs Tromeur Lionel Weinberg Juan Carlos Higareda Almaraz Marcel Scheideler Marion Rietveld Abdoel El Ghalbzouri Erwin Tschachler Florian Gruber Johannes Grillari |
| author_sort |
Ingo Lämmermann |
| title |
Blocking negative effects of senescence in human skin fibroblasts with a plant extract |
| title_short |
Blocking negative effects of senescence in human skin fibroblasts with a plant extract |
| title_full |
Blocking negative effects of senescence in human skin fibroblasts with a plant extract |
| title_fullStr |
Blocking negative effects of senescence in human skin fibroblasts with a plant extract |
| title_full_unstemmed |
Blocking negative effects of senescence in human skin fibroblasts with a plant extract |
| title_sort |
blocking negative effects of senescence in human skin fibroblasts with a plant extract |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/1e51e56bcd8c4ecab59c13e58909e43a |
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