Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model

Abstract Mild head trauma, including concussion, can lead to chronic brain dysfunction and degeneration but the underlying mechanisms remain poorly understood. Here, we developed a novel head impact system to investigate the long-term effects of mild head trauma on brain structure and function, as w...

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Autores principales:	Joseph A. Behnke, Changtian Ye, Aayush Setty, Kenneth H. Moberg, James Q. Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e54ff96cb5c44758efa7d689630aea1
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spelling	oai:doaj.org-article:1e54ff96cb5c44758efa7d689630aea12021-12-02T15:37:59ZRepetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model10.1038/s41598-021-89121-72045-2322https://doaj.org/article/1e54ff96cb5c44758efa7d689630aea12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89121-7https://doaj.org/toc/2045-2322Abstract Mild head trauma, including concussion, can lead to chronic brain dysfunction and degeneration but the underlying mechanisms remain poorly understood. Here, we developed a novel head impact system to investigate the long-term effects of mild head trauma on brain structure and function, as well as the underlying mechanisms in Drosophila melanogaster. We find that Drosophila subjected to repetitive head impacts develop long-term deficits, including impaired startle-induced climbing, progressive brain degeneration, and shortened lifespan, all of which are substantially exacerbated in female flies. Interestingly, head impacts elicit an elevation in neuronal activity and its acute suppression abrogates the detrimental effects in female flies. Together, our findings validate Drosophila as a suitable model system for investigating the long-term effects of mild head trauma, suggest an increased vulnerability to brain injury in female flies, and indicate that early altered neuronal excitability may be a key mechanism linking mild brain trauma to chronic degeneration.Joseph A. BehnkeChangtian YeAayush SettyKenneth H. MobergJames Q. ZhengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph A. Behnke Changtian Ye Aayush Setty Kenneth H. Moberg James Q. Zheng Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
description	Abstract Mild head trauma, including concussion, can lead to chronic brain dysfunction and degeneration but the underlying mechanisms remain poorly understood. Here, we developed a novel head impact system to investigate the long-term effects of mild head trauma on brain structure and function, as well as the underlying mechanisms in Drosophila melanogaster. We find that Drosophila subjected to repetitive head impacts develop long-term deficits, including impaired startle-induced climbing, progressive brain degeneration, and shortened lifespan, all of which are substantially exacerbated in female flies. Interestingly, head impacts elicit an elevation in neuronal activity and its acute suppression abrogates the detrimental effects in female flies. Together, our findings validate Drosophila as a suitable model system for investigating the long-term effects of mild head trauma, suggest an increased vulnerability to brain injury in female flies, and indicate that early altered neuronal excitability may be a key mechanism linking mild brain trauma to chronic degeneration.
format	article
author	Joseph A. Behnke Changtian Ye Aayush Setty Kenneth H. Moberg James Q. Zheng
author_facet	Joseph A. Behnke Changtian Ye Aayush Setty Kenneth H. Moberg James Q. Zheng
author_sort	Joseph A. Behnke
title	Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
title_short	Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
title_full	Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
title_fullStr	Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
title_full_unstemmed	Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
title_sort	repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel drosophila model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1e54ff96cb5c44758efa7d689630aea1
work_keys_str_mv	AT josephabehnke repetitivemildheadtraumainducesactivitymediatedlifelongbraindeficitsinanoveldrosophilamodel AT changtianye repetitivemildheadtraumainducesactivitymediatedlifelongbraindeficitsinanoveldrosophilamodel AT aayushsetty repetitivemildheadtraumainducesactivitymediatedlifelongbraindeficitsinanoveldrosophilamodel AT kennethhmoberg repetitivemildheadtraumainducesactivitymediatedlifelongbraindeficitsinanoveldrosophilamodel AT jamesqzheng repetitivemildheadtraumainducesactivitymediatedlifelongbraindeficitsinanoveldrosophilamodel
_version_	1718386158071709696

Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model

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