PRELIMINARY CLINICAL RESULTS WITH LIPOASPIRATE STROMAL VASCULAR CELL FRACTION IN TREATMENT OF PATIENTS WITH KNEE OSTEOARTHRITIS

The paper presents results of clinical application of autologous stromal-vascular fraction (SVF) cells in patients with degenerative osteoarthritis (OA) of the knee, grade II and III (Kellgren–Lawrence scale).We recruited six patients with knee OA (3 men and 3 women; median age 64 years) with mean d...

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Autores principales:	E. Ya. Shevela, N. A. Nitsa, N. M. Starostina, S. I. Baranov, Yu. A. Kozhevnikov, N. D. Popova, E. V. Batorov, A. A. Ostanin, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	stromal-vascular fraction osteoarthritis vas scale koos scale Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1e57e7b28b7f46bd858e259c1999e518
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spelling	oai:doaj.org-article:1e57e7b28b7f46bd858e259c1999e5182021-11-18T08:03:46ZPRELIMINARY CLINICAL RESULTS WITH LIPOASPIRATE STROMAL VASCULAR CELL FRACTION IN TREATMENT OF PATIENTS WITH KNEE OSTEOARTHRITIS1563-06252313-741X10.15789/1563-0625-2017-6-779-788https://doaj.org/article/1e57e7b28b7f46bd858e259c1999e5182017-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1402https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe paper presents results of clinical application of autologous stromal-vascular fraction (SVF) cells in patients with degenerative osteoarthritis (OA) of the knee, grade II and III (Kellgren–Lawrence scale).We recruited six patients with knee OA (3 men and 3 women; median age 64 years) with mean disease duration of 7 years. All the patients were administered a single intra-articular injection of autologous nucleated SVF cells at an average dose of 16.8±0.9 × 106 per joint (a total of 11 joints). The patients did not experience any serious side effects (allergic, toxic or inflammatory) related to the knee injection. Patient surveys at 1 month after SVF administration revealed a decrease in the severity of pain, as measured by a visual analog scale (VAS) and a specialized 100-point scale KOOS (subscale "pain") (p < 0.05 on both scales). Moreover, the patients reported improvement in the joint functions and quality of life related to affected joints on a KOOS scale (p < 0.05). These positive clinical changes persisted during 6 month follow up. Significant improvements were noted in ultrasound findings, with increased thickness of the cartilage layer at 3 months (in 73% of cases) and at 6 months (in 82%). Our pilot study demonstrated the safety and tolerability of intra-articular injection of autologous SVF cells in patients with moderate to severe OA. The results obtained also indicate a significant antiinflammatory effect of autologous adipose tissue SVF cells, which is manifested at the early stages of cell therapy. Our further investigations will be focused on exploring the SVF stimulatory effects on regeneration of damaged joints.E. Ya. ShevelaN. A. NitsaN. M. StarostinaS. I. BaranovYu. A. KozhevnikovN. D. PopovaE. V. BatorovA. A. OstaninE. R. ChernykhSPb RAACIarticlestromal-vascular fractionosteoarthritisvas scalekoos scaleImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 6, Pp 779-788 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	stromal-vascular fraction osteoarthritis vas scale koos scale Immunologic diseases. Allergy RC581-607
spellingShingle	stromal-vascular fraction osteoarthritis vas scale koos scale Immunologic diseases. Allergy RC581-607 E. Ya. Shevela N. A. Nitsa N. M. Starostina S. I. Baranov Yu. A. Kozhevnikov N. D. Popova E. V. Batorov A. A. Ostanin E. R. Chernykh PRELIMINARY CLINICAL RESULTS WITH LIPOASPIRATE STROMAL VASCULAR CELL FRACTION IN TREATMENT OF PATIENTS WITH KNEE OSTEOARTHRITIS
description	The paper presents results of clinical application of autologous stromal-vascular fraction (SVF) cells in patients with degenerative osteoarthritis (OA) of the knee, grade II and III (Kellgren–Lawrence scale).We recruited six patients with knee OA (3 men and 3 women; median age 64 years) with mean disease duration of 7 years. All the patients were administered a single intra-articular injection of autologous nucleated SVF cells at an average dose of 16.8±0.9 × 106 per joint (a total of 11 joints). The patients did not experience any serious side effects (allergic, toxic or inflammatory) related to the knee injection. Patient surveys at 1 month after SVF administration revealed a decrease in the severity of pain, as measured by a visual analog scale (VAS) and a specialized 100-point scale KOOS (subscale "pain") (p < 0.05 on both scales). Moreover, the patients reported improvement in the joint functions and quality of life related to affected joints on a KOOS scale (p < 0.05). These positive clinical changes persisted during 6 month follow up. Significant improvements were noted in ultrasound findings, with increased thickness of the cartilage layer at 3 months (in 73% of cases) and at 6 months (in 82%). Our pilot study demonstrated the safety and tolerability of intra-articular injection of autologous SVF cells in patients with moderate to severe OA. The results obtained also indicate a significant antiinflammatory effect of autologous adipose tissue SVF cells, which is manifested at the early stages of cell therapy. Our further investigations will be focused on exploring the SVF stimulatory effects on regeneration of damaged joints.
format	article
author	E. Ya. Shevela N. A. Nitsa N. M. Starostina S. I. Baranov Yu. A. Kozhevnikov N. D. Popova E. V. Batorov A. A. Ostanin E. R. Chernykh
author_facet	E. Ya. Shevela N. A. Nitsa N. M. Starostina S. I. Baranov Yu. A. Kozhevnikov N. D. Popova E. V. Batorov A. A. Ostanin E. R. Chernykh
author_sort	E. Ya. Shevela
title	PRELIMINARY CLINICAL RESULTS WITH LIPOASPIRATE STROMAL VASCULAR CELL FRACTION IN TREATMENT OF PATIENTS WITH KNEE OSTEOARTHRITIS
title_short	PRELIMINARY CLINICAL RESULTS WITH LIPOASPIRATE STROMAL VASCULAR CELL FRACTION IN TREATMENT OF PATIENTS WITH KNEE OSTEOARTHRITIS
title_full	PRELIMINARY CLINICAL RESULTS WITH LIPOASPIRATE STROMAL VASCULAR CELL FRACTION IN TREATMENT OF PATIENTS WITH KNEE OSTEOARTHRITIS
title_fullStr	PRELIMINARY CLINICAL RESULTS WITH LIPOASPIRATE STROMAL VASCULAR CELL FRACTION IN TREATMENT OF PATIENTS WITH KNEE OSTEOARTHRITIS
title_full_unstemmed	PRELIMINARY CLINICAL RESULTS WITH LIPOASPIRATE STROMAL VASCULAR CELL FRACTION IN TREATMENT OF PATIENTS WITH KNEE OSTEOARTHRITIS
title_sort	preliminary clinical results with lipoaspirate stromal vascular cell fraction in treatment of patients with knee osteoarthritis
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/1e57e7b28b7f46bd858e259c1999e518
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PRELIMINARY CLINICAL RESULTS WITH LIPOASPIRATE STROMAL VASCULAR CELL FRACTION IN TREATMENT OF PATIENTS WITH KNEE OSTEOARTHRITIS

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