Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease

Abstract Background An early appropriate response is the cornerstone of treatment for invasive meningococcal disease. Little evidence exists on how cases with invasive meningococcal disease present at first contact to emergency medical services. Methods Retrospective observational study of cases pre...

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Autores principales:	Nichlas Hovmand, Helle Collatz Christensen, Lene Fogt Lundbo, Håkon Sandholdt, Gitte Kronborg, Perle Darsø, Jacob Anhøj, Stig Nikolaj Fasmer Blomberg, Asmus Thun Bisgaard, Thomas Benfield
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Infection Emergency care systems Prehospital care Meningitis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1e58938cbb0a44aaab4e6d34a9faff72
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spelling	oai:doaj.org-article:1e58938cbb0a44aaab4e6d34a9faff722021-12-05T12:20:39ZNonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease10.1186/s12875-021-01585-81471-2296https://doaj.org/article/1e58938cbb0a44aaab4e6d34a9faff722021-11-01T00:00:00Zhttps://doi.org/10.1186/s12875-021-01585-8https://doaj.org/toc/1471-2296Abstract Background An early appropriate response is the cornerstone of treatment for invasive meningococcal disease. Little evidence exists on how cases with invasive meningococcal disease present at first contact to emergency medical services. Methods Retrospective observational study of cases presenting with invasive meningococcal disease from January 1st of 2016 to December 31st of 2020 in the Capital Region of Denmark with a catchment area population of 1,800,000. A single medical emergency center provides services to the region. Data was collected from emergency medical services’ call audio files, data from the call receiver registrations, registrations from ambulance personal and electronic health record data from the hospitalization. Results Of 1527 cases suspected of meningitis, 38 had invasive meningococcal disease and had been in contact with the emergency service. Most contacts were to the medical helpline rather than the emergency call center at initial contact to emergency medical services. All were hospitalized within 12 h. At initial contact, fever was present in 28 (74%) of 38 cases, while specific symptoms such as headache (n=12 (32%)), a rash or petechiae (n=9 (23%)) and stiffness of the neck (n=4 (11%)) varied and were infrequent. Cases younger than 18 years of age were more often male and more often presented with fever and rash/petechiae. Only 4 (11%) received prehospital antibiotic treatment. Conclusions Cases with invasive meningococcal disease presented with fever and unspecific symptoms. Although few were acutely ill at their initial contact, all were admitted within 12 h. We suggest that all feverish cases should be systematically asked about specific symptoms and should be wary of symptom progression to optimize the early management if cases with invasive meningococcal disease.Nichlas HovmandHelle Collatz ChristensenLene Fogt LundboHåkon SandholdtGitte KronborgPerle DarsøJacob AnhøjStig Nikolaj Fasmer BlombergAsmus Thun BisgaardThomas BenfieldBMCarticleInfectionEmergency care systemsPrehospital careMeningitisMedicine (General)R5-920ENBMC Family Practice, Vol 22, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infection Emergency care systems Prehospital care Meningitis Medicine (General) R5-920
spellingShingle	Infection Emergency care systems Prehospital care Meningitis Medicine (General) R5-920 Nichlas Hovmand Helle Collatz Christensen Lene Fogt Lundbo Håkon Sandholdt Gitte Kronborg Perle Darsø Jacob Anhøj Stig Nikolaj Fasmer Blomberg Asmus Thun Bisgaard Thomas Benfield Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease
description	Abstract Background An early appropriate response is the cornerstone of treatment for invasive meningococcal disease. Little evidence exists on how cases with invasive meningococcal disease present at first contact to emergency medical services. Methods Retrospective observational study of cases presenting with invasive meningococcal disease from January 1st of 2016 to December 31st of 2020 in the Capital Region of Denmark with a catchment area population of 1,800,000. A single medical emergency center provides services to the region. Data was collected from emergency medical services’ call audio files, data from the call receiver registrations, registrations from ambulance personal and electronic health record data from the hospitalization. Results Of 1527 cases suspected of meningitis, 38 had invasive meningococcal disease and had been in contact with the emergency service. Most contacts were to the medical helpline rather than the emergency call center at initial contact to emergency medical services. All were hospitalized within 12 h. At initial contact, fever was present in 28 (74%) of 38 cases, while specific symptoms such as headache (n=12 (32%)), a rash or petechiae (n=9 (23%)) and stiffness of the neck (n=4 (11%)) varied and were infrequent. Cases younger than 18 years of age were more often male and more often presented with fever and rash/petechiae. Only 4 (11%) received prehospital antibiotic treatment. Conclusions Cases with invasive meningococcal disease presented with fever and unspecific symptoms. Although few were acutely ill at their initial contact, all were admitted within 12 h. We suggest that all feverish cases should be systematically asked about specific symptoms and should be wary of symptom progression to optimize the early management if cases with invasive meningococcal disease.
format	article
author	Nichlas Hovmand Helle Collatz Christensen Lene Fogt Lundbo Håkon Sandholdt Gitte Kronborg Perle Darsø Jacob Anhøj Stig Nikolaj Fasmer Blomberg Asmus Thun Bisgaard Thomas Benfield
author_facet	Nichlas Hovmand Helle Collatz Christensen Lene Fogt Lundbo Håkon Sandholdt Gitte Kronborg Perle Darsø Jacob Anhøj Stig Nikolaj Fasmer Blomberg Asmus Thun Bisgaard Thomas Benfield
author_sort	Nichlas Hovmand
title	Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease
title_short	Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease
title_full	Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease
title_fullStr	Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease
title_full_unstemmed	Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease
title_sort	nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1e58938cbb0a44aaab4e6d34a9faff72
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Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease

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