Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons

Abstract Cognitive dysfunction associated with radiotherapy for cancer treatment has been correlated to several factors, one of which is changes to the dendritic morphology of neuronal cells. Alterations in dendritic geometry and branching patterns are often accompanied by deficits that impact learn...

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Autores principales:	Eliedonna Cacao, Vipan K. Parihar, Charles L. Limoli, Francis A. Cucinotta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e5927eecc6040f9be7efab00ddbac2a
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spelling	oai:doaj.org-article:1e5927eecc6040f9be7efab00ddbac2a2021-12-02T15:08:25ZStochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons10.1038/s41598-018-23855-92045-2322https://doaj.org/article/1e5927eecc6040f9be7efab00ddbac2a2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-23855-9https://doaj.org/toc/2045-2322Abstract Cognitive dysfunction associated with radiotherapy for cancer treatment has been correlated to several factors, one of which is changes to the dendritic morphology of neuronal cells. Alterations in dendritic geometry and branching patterns are often accompanied by deficits that impact learning and memory. The purpose of this study is to develop a novel predictive model of neuronal dendritic damages caused by exposure to low linear energy transfer (LET) radiation, such as X-rays, γ-rays and high-energy protons. We established in silico representations of mouse hippocampal dentate granule cell layer (GCL) and CA1 pyramidal neurons, which are frequently examined in radiation-induced cognitive decrements. The in silico representations are used in a stochastic model that describes time dependent dendritic damage induced by exposure to low LET radiation. Changes in morphometric parameters, such as total dendritic length, number of branch points and branch number, including the Sholl analysis for single neurons are described by the model. Our model based predictions for different patterns of morphological changes based on energy deposition in dendritic segments (EDDS) will serve as a useful basis to compare specific patterns of morphological alterations caused by EDDS mechanisms.Eliedonna CacaoVipan K. PariharCharles L. LimoliFrancis A. CucinottaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eliedonna Cacao Vipan K. Parihar Charles L. Limoli Francis A. Cucinotta Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons
description	Abstract Cognitive dysfunction associated with radiotherapy for cancer treatment has been correlated to several factors, one of which is changes to the dendritic morphology of neuronal cells. Alterations in dendritic geometry and branching patterns are often accompanied by deficits that impact learning and memory. The purpose of this study is to develop a novel predictive model of neuronal dendritic damages caused by exposure to low linear energy transfer (LET) radiation, such as X-rays, γ-rays and high-energy protons. We established in silico representations of mouse hippocampal dentate granule cell layer (GCL) and CA1 pyramidal neurons, which are frequently examined in radiation-induced cognitive decrements. The in silico representations are used in a stochastic model that describes time dependent dendritic damage induced by exposure to low LET radiation. Changes in morphometric parameters, such as total dendritic length, number of branch points and branch number, including the Sholl analysis for single neurons are described by the model. Our model based predictions for different patterns of morphological changes based on energy deposition in dendritic segments (EDDS) will serve as a useful basis to compare specific patterns of morphological alterations caused by EDDS mechanisms.
format	article
author	Eliedonna Cacao Vipan K. Parihar Charles L. Limoli Francis A. Cucinotta
author_facet	Eliedonna Cacao Vipan K. Parihar Charles L. Limoli Francis A. Cucinotta
author_sort	Eliedonna Cacao
title	Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons
title_short	Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons
title_full	Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons
title_fullStr	Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons
title_full_unstemmed	Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons
title_sort	stochastic modeling of radiation-induced dendritic damage on in silico mouse hippocampal neurons
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1e5927eecc6040f9be7efab00ddbac2a
work_keys_str_mv	AT eliedonnacacao stochasticmodelingofradiationinduceddendriticdamageoninsilicomousehippocampalneurons AT vipankparihar stochasticmodelingofradiationinduceddendriticdamageoninsilicomousehippocampalneurons AT charlesllimoli stochasticmodelingofradiationinduceddendriticdamageoninsilicomousehippocampalneurons AT francisacucinotta stochasticmodelingofradiationinduceddendriticdamageoninsilicomousehippocampalneurons
_version_	1718388108706185216

Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons

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