Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study [version 2; peer review: 2 approved]

Introduction: COVID-19 can be worsened by hyper-production of cytokines accompanied by increased level of oxidative stress. The aim of this study was to investigate the correlation between a set of cytokines and the markers of the oxidative stress. Methods: The levels of cytokines IL-2, IL-4, IL-6,...

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Autores principales:	Marija Petrushevska, Dragica Zendelovska, Emilija Atanasovska, Aleksandar Eftimov, Katerina Spasovska
Formato:	article
Lenguaje:	EN
Publicado:	F1000 Research Ltd 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e592d8f4c7c437e8f2cd868e795ab1f
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spelling	oai:doaj.org-article:1e592d8f4c7c437e8f2cd868e795ab1f2021-11-22T12:41:06ZPresentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study [version 2; peer review: 2 approved]2046-140210.12688/f1000research.55166.2https://doaj.org/article/1e592d8f4c7c437e8f2cd868e795ab1f2021-10-01T00:00:00Zhttps://f1000research.com/articles/10-719/v2https://doaj.org/toc/2046-1402Introduction: COVID-19 can be worsened by hyper-production of cytokines accompanied by increased level of oxidative stress. The aim of this study was to investigate the correlation between a set of cytokines and the markers of the oxidative stress. Methods: The levels of cytokines IL-2, IL-4, IL-6, IL8, IL-10, VEGF, IFN-γ, TNF-α, IL-1α, MCP-1 and EGF were determined by using High Sensitivity Evidence Investigator™ Biochip Array technology. The oxidative stress parameters (d-ROM, PAT, OS index) were measured in serum on FRAS5 analytical photometric system. Results: IL-6, IL-8, IL-10, VEGF, MCP-1 and EGF were significantly higher (p<0.05) in the patients with severe COVID-19 with increased levels of IL-2, IFN-y, TNF-α and IL-1α. The d-ROM, OS index, and PAT were significantly higher (p<0.05) in severe COVID-19 patients. IL-6 demonstrated the strongest correlation with all of the markers of the oxidative stress, d-ROM (r=0.9725, p=0.0001), PAT (r=0.5000, p=0.0001) and OS index (r=0.9593, p=0.012). Similar behavior was evidenced between IFN-y and d-ROM (r=0.4006, p=0.0001), PAT (r=0.6030, p=0.0001) and OS index (r=0.4298, p=0.012). Conclusion: The oxidative stress markers show good correlation with the tested cytokines which can be measured at the beginning of the disease in a primary care setting to predict the course of COVID-19.Marija PetrushevskaDragica ZendelovskaEmilija AtanasovskaAleksandar EftimovKaterina SpasovskaF1000 Research LtdarticleMedicineRScienceQENF1000Research, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marija Petrushevska Dragica Zendelovska Emilija Atanasovska Aleksandar Eftimov Katerina Spasovska Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study [version 2; peer review: 2 approved]
description	Introduction: COVID-19 can be worsened by hyper-production of cytokines accompanied by increased level of oxidative stress. The aim of this study was to investigate the correlation between a set of cytokines and the markers of the oxidative stress. Methods: The levels of cytokines IL-2, IL-4, IL-6, IL8, IL-10, VEGF, IFN-γ, TNF-α, IL-1α, MCP-1 and EGF were determined by using High Sensitivity Evidence Investigator™ Biochip Array technology. The oxidative stress parameters (d-ROM, PAT, OS index) were measured in serum on FRAS5 analytical photometric system. Results: IL-6, IL-8, IL-10, VEGF, MCP-1 and EGF were significantly higher (p<0.05) in the patients with severe COVID-19 with increased levels of IL-2, IFN-y, TNF-α and IL-1α. The d-ROM, OS index, and PAT were significantly higher (p<0.05) in severe COVID-19 patients. IL-6 demonstrated the strongest correlation with all of the markers of the oxidative stress, d-ROM (r=0.9725, p=0.0001), PAT (r=0.5000, p=0.0001) and OS index (r=0.9593, p=0.012). Similar behavior was evidenced between IFN-y and d-ROM (r=0.4006, p=0.0001), PAT (r=0.6030, p=0.0001) and OS index (r=0.4298, p=0.012). Conclusion: The oxidative stress markers show good correlation with the tested cytokines which can be measured at the beginning of the disease in a primary care setting to predict the course of COVID-19.
format	article
author	Marija Petrushevska Dragica Zendelovska Emilija Atanasovska Aleksandar Eftimov Katerina Spasovska
author_facet	Marija Petrushevska Dragica Zendelovska Emilija Atanasovska Aleksandar Eftimov Katerina Spasovska
author_sort	Marija Petrushevska
title	Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study [version 2; peer review: 2 approved]
title_short	Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study [version 2; peer review: 2 approved]
title_full	Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study [version 2; peer review: 2 approved]
title_fullStr	Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study [version 2; peer review: 2 approved]
title_full_unstemmed	Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study [version 2; peer review: 2 approved]
title_sort	presentation of cytokine profile in relation to oxidative stress parameters in patients with severe covid-19: a case-control pilot study [version 2; peer review: 2 approved]
publisher	F1000 Research Ltd
publishDate	2021
url	https://doaj.org/article/1e592d8f4c7c437e8f2cd868e795ab1f
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Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study [version 2; peer review: 2 approved]

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