Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis

Cytomegalovirus (CMV) infection is associated with exacerbation of disease activity in patients with ulcerative colitis (UC). However, the risk factors for CMV reactivation in this population remain debatable. This meta-analysis was performed to identify the risk factors for CMV reactivation in UC p...

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Autores principales:	Yafei Qin, Grace Wang, Dejun Kong, Guangming Li, Hongda Wang, Hong Qin, Hao Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ulcerative colitis cytomegalovirus risk factors meta-analysis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1e59d68dff354b08b8d323772a21d560
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spelling	oai:doaj.org-article:1e59d68dff354b08b8d323772a21d5602021-11-25T17:20:10ZRisk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis10.3390/diagnostics111119522075-4418https://doaj.org/article/1e59d68dff354b08b8d323772a21d5602021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1952https://doaj.org/toc/2075-4418Cytomegalovirus (CMV) infection is associated with exacerbation of disease activity in patients with ulcerative colitis (UC). However, the risk factors for CMV reactivation in this population remain debatable. This meta-analysis was performed to identify the risk factors for CMV reactivation in UC patients. PubMed, Cochrane Library, EMBASE, Web of Science, and China National Knowledge Infrastructure were searched from the inception of these databases to 31 August 2021, with the aim of identifying studies that investigated the risk factors of CMV reactivation in UC patients. A quality assessment of the included studies was performed with the Newcastle-Ottawa Scale. The publication bias was assessed respectively via a funnel plot and Egger’s regression asymmetry test. The robustness and reliability of each outcome were evaluated by sensitivity analysis. Twenty studies were included in the final meta-analysis, comprising a total of 2099 patients with UC. A significantly higher risk of CMV reactivation was observed in patients with severe UC (OR = 1.465, 95% CI: 1.107 to 1.939, <i>p</i> = 0.008), pancolitis (OR = 2.108, 95% CI: 1.586 to 2.800, <i>p</i> = 0.0001), older age of UC onset (MD = 6.212, 95% CI: 2.552 to 9.971, <i>p</i> = 0.001), as well as use of glucocorticoids (OR = 4.175, 95% CI: 3.076 to 5.666, <i>p</i> = 0.001), immunosuppressants (OR = 1.795, 95% CI: 1.289 to 2.501, <i>p</i> = 0.001), and azathioprine (OR = 1.444, 95% CI: 1.012 to 2.061, <i>p</i> = 0.043). However, infliximab treatment was observed not to increase the occurrence of CMV reactivation in patients who suffered from UC. In contrast, 5-aminosalicylic acid (OR = 0.674, 95% CI: 0.492 to 0.924, <i>p</i> = 0.014) was associated with a lower risk of CMV reactivation. Patients with UC should be closely monitored for risk factors of CMV reactivation in order to provide timely diagnosis and antiviral treatment.Yafei QinGrace WangDejun KongGuangming LiHongda WangHong QinHao WangMDPI AGarticleulcerative colitiscytomegalovirusrisk factorsmeta-analysisMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1952, p 1952 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ulcerative colitis cytomegalovirus risk factors meta-analysis Medicine (General) R5-920
spellingShingle	ulcerative colitis cytomegalovirus risk factors meta-analysis Medicine (General) R5-920 Yafei Qin Grace Wang Dejun Kong Guangming Li Hongda Wang Hong Qin Hao Wang Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis
description	Cytomegalovirus (CMV) infection is associated with exacerbation of disease activity in patients with ulcerative colitis (UC). However, the risk factors for CMV reactivation in this population remain debatable. This meta-analysis was performed to identify the risk factors for CMV reactivation in UC patients. PubMed, Cochrane Library, EMBASE, Web of Science, and China National Knowledge Infrastructure were searched from the inception of these databases to 31 August 2021, with the aim of identifying studies that investigated the risk factors of CMV reactivation in UC patients. A quality assessment of the included studies was performed with the Newcastle-Ottawa Scale. The publication bias was assessed respectively via a funnel plot and Egger’s regression asymmetry test. The robustness and reliability of each outcome were evaluated by sensitivity analysis. Twenty studies were included in the final meta-analysis, comprising a total of 2099 patients with UC. A significantly higher risk of CMV reactivation was observed in patients with severe UC (OR = 1.465, 95% CI: 1.107 to 1.939, <i>p</i> = 0.008), pancolitis (OR = 2.108, 95% CI: 1.586 to 2.800, <i>p</i> = 0.0001), older age of UC onset (MD = 6.212, 95% CI: 2.552 to 9.971, <i>p</i> = 0.001), as well as use of glucocorticoids (OR = 4.175, 95% CI: 3.076 to 5.666, <i>p</i> = 0.001), immunosuppressants (OR = 1.795, 95% CI: 1.289 to 2.501, <i>p</i> = 0.001), and azathioprine (OR = 1.444, 95% CI: 1.012 to 2.061, <i>p</i> = 0.043). However, infliximab treatment was observed not to increase the occurrence of CMV reactivation in patients who suffered from UC. In contrast, 5-aminosalicylic acid (OR = 0.674, 95% CI: 0.492 to 0.924, <i>p</i> = 0.014) was associated with a lower risk of CMV reactivation. Patients with UC should be closely monitored for risk factors of CMV reactivation in order to provide timely diagnosis and antiviral treatment.
format	article
author	Yafei Qin Grace Wang Dejun Kong Guangming Li Hongda Wang Hong Qin Hao Wang
author_facet	Yafei Qin Grace Wang Dejun Kong Guangming Li Hongda Wang Hong Qin Hao Wang
author_sort	Yafei Qin
title	Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis
title_short	Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis
title_full	Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis
title_fullStr	Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis
title_full_unstemmed	Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis
title_sort	risk factors of cytomegalovirus reactivation in ulcerative colitis patients: a meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1e59d68dff354b08b8d323772a21d560
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Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis

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