Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications

Nanofibers as elements for bioscaffolds are pushing the development of tissue engineering. In this study, tussah silk was mechanically disintegrated into nanofibers dispersed in aqueous solution which was cast to generate tussah silk fibroin (TSF) nanofiber mats. The effect of treatment time on the...

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Autores principales:	Ming Chen, Jianzhong Qin, Shijun Lu, Feng Zhang, Baoqi Zuo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tussah silk nanofiber nonwoven mats mechanical properties biocompatibility Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/1e5fb8c69a114da3b94f4920521c2926
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spelling	oai:doaj.org-article:1e5fb8c69a114da3b94f4920521c29262021-12-02T10:54:10ZRobust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications2296-418510.3389/fbioe.2021.746016https://doaj.org/article/1e5fb8c69a114da3b94f4920521c29262021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.746016/fullhttps://doaj.org/toc/2296-4185Nanofibers as elements for bioscaffolds are pushing the development of tissue engineering. In this study, tussah silk was mechanically disintegrated into nanofibers dispersed in aqueous solution which was cast to generate tussah silk fibroin (TSF) nanofiber mats. The effect of treatment time on the morphology, structure, and mechanical properties of nanofiber mats was examined. SEM indicated decreasing diameter of the nanofiber with shearing time, and the diameter of the nanofiber was 139.7 nm after 30 min treatment. These nanofiber mats exhibited excellent mechanical properties; the breaking strength increased from 26.31 to 72.68 MPa with the decrease of fiber diameter from 196.5 to 139.7 nm. The particulate debris was observed on protease XIV degraded nanofiber mats, and the weight loss was greater than 10% after 30 days in vitro degradation. The cell compatibility experiment confirmed adhesion and spreading of NIH-3T3 cells and enhanced cell proliferation on TSF nanofiber mats compared to that on Bombyx mori silk nanofiber mats. In conclusion, results indicate that TSF nanofiber mats prepared in this study are mechanically robust, slow biodegradable, and biocompatible materials, and have promising application in regenerative medicine.Ming ChenMing ChenJianzhong QinJianzhong QinShijun LuFeng ZhangBaoqi ZuoFrontiers Media S.A.articletussah silknanofibernonwoven matsmechanical propertiesbiocompatibilityBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tussah silk nanofiber nonwoven mats mechanical properties biocompatibility Biotechnology TP248.13-248.65
spellingShingle	tussah silk nanofiber nonwoven mats mechanical properties biocompatibility Biotechnology TP248.13-248.65 Ming Chen Ming Chen Jianzhong Qin Jianzhong Qin Shijun Lu Feng Zhang Baoqi Zuo Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications
description	Nanofibers as elements for bioscaffolds are pushing the development of tissue engineering. In this study, tussah silk was mechanically disintegrated into nanofibers dispersed in aqueous solution which was cast to generate tussah silk fibroin (TSF) nanofiber mats. The effect of treatment time on the morphology, structure, and mechanical properties of nanofiber mats was examined. SEM indicated decreasing diameter of the nanofiber with shearing time, and the diameter of the nanofiber was 139.7 nm after 30 min treatment. These nanofiber mats exhibited excellent mechanical properties; the breaking strength increased from 26.31 to 72.68 MPa with the decrease of fiber diameter from 196.5 to 139.7 nm. The particulate debris was observed on protease XIV degraded nanofiber mats, and the weight loss was greater than 10% after 30 days in vitro degradation. The cell compatibility experiment confirmed adhesion and spreading of NIH-3T3 cells and enhanced cell proliferation on TSF nanofiber mats compared to that on Bombyx mori silk nanofiber mats. In conclusion, results indicate that TSF nanofiber mats prepared in this study are mechanically robust, slow biodegradable, and biocompatible materials, and have promising application in regenerative medicine.
format	article
author	Ming Chen Ming Chen Jianzhong Qin Jianzhong Qin Shijun Lu Feng Zhang Baoqi Zuo
author_facet	Ming Chen Ming Chen Jianzhong Qin Jianzhong Qin Shijun Lu Feng Zhang Baoqi Zuo
author_sort	Ming Chen
title	Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications
title_short	Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications
title_full	Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications
title_fullStr	Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications
title_full_unstemmed	Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications
title_sort	robust nanofiber mats exfoliated from tussah silk for potential biomedical applications
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1e5fb8c69a114da3b94f4920521c2926
work_keys_str_mv	AT mingchen robustnanofibermatsexfoliatedfromtussahsilkforpotentialbiomedicalapplications AT mingchen robustnanofibermatsexfoliatedfromtussahsilkforpotentialbiomedicalapplications AT jianzhongqin robustnanofibermatsexfoliatedfromtussahsilkforpotentialbiomedicalapplications AT jianzhongqin robustnanofibermatsexfoliatedfromtussahsilkforpotentialbiomedicalapplications AT shijunlu robustnanofibermatsexfoliatedfromtussahsilkforpotentialbiomedicalapplications AT fengzhang robustnanofibermatsexfoliatedfromtussahsilkforpotentialbiomedicalapplications AT baoqizuo robustnanofibermatsexfoliatedfromtussahsilkforpotentialbiomedicalapplications
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Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications

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