Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle

The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the modern TCA cycle, shedding light into a plausible TCA...

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Autores principales:	Greg Springsteen, Jayasudhan Reddy Yerabolu, Julia Nelson, Chandler Joel Rhea, Ramanarayanan Krishnamurthy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e6144bbca0e42bb8932fe4c609492ca
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spelling	oai:doaj.org-article:1e6144bbca0e42bb8932fe4c609492ca2021-12-02T15:34:27ZLinked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle10.1038/s41467-017-02591-02041-1723https://doaj.org/article/1e6144bbca0e42bb8932fe4c609492ca2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02591-0https://doaj.org/toc/2041-1723The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the modern TCA cycle, shedding light into a plausible TCA protometabolism.Greg SpringsteenJayasudhan Reddy YeraboluJulia NelsonChandler Joel RheaRamanarayanan KrishnamurthyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Greg Springsteen Jayasudhan Reddy Yerabolu Julia Nelson Chandler Joel Rhea Ramanarayanan Krishnamurthy Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle
description	The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the modern TCA cycle, shedding light into a plausible TCA protometabolism.
format	article
author	Greg Springsteen Jayasudhan Reddy Yerabolu Julia Nelson Chandler Joel Rhea Ramanarayanan Krishnamurthy
author_facet	Greg Springsteen Jayasudhan Reddy Yerabolu Julia Nelson Chandler Joel Rhea Ramanarayanan Krishnamurthy
author_sort	Greg Springsteen
title	Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle
title_short	Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle
title_full	Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle
title_fullStr	Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle
title_full_unstemmed	Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle
title_sort	linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1e6144bbca0e42bb8932fe4c609492ca
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Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle

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