Clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa

Objective: To evaluate the margins of resected specimen of oral squamous cell carcinoma (SCC) and to document the surgical margin (measured at the time of resection) and margins at the time of pathological examination (after immersion of the specimen in formalin). Methods: Patients who were diagnose...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	S.M. Azeem Mohiyuddin, B. Vageesh Padiyar, T.N. Suresh, Kouser Mohammadi, A. Sagayaraj, Shuaib Merchant, Mahnaaz Sultana Azeem
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/1e6164903653445998cecc44ea365323
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1e6164903653445998cecc44ea365323
record_format	dspace
spelling	oai:doaj.org-article:1e6164903653445998cecc44ea3653232021-12-02T11:49:46ZClinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa2095-881110.1016/j.wjorl.2016.02.003https://doaj.org/article/1e6164903653445998cecc44ea3653232016-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881116300014https://doaj.org/toc/2095-8811Objective: To evaluate the margins of resected specimen of oral squamous cell carcinoma (SCC) and to document the surgical margin (measured at the time of resection) and margins at the time of pathological examination (after immersion of the specimen in formalin). Methods: Patients who were diagnosed and confirmed with squamous carcinoma of buccal mucosa were included in the study. Patients underwent resection of the tumor with a margin of 1 cm. Soon after resection, the distance between outermost visible margin of the tumor and the margin of the specimen was measured and documented. Specimens were fixed in 10% formalin and submitted for gross and histopathological examination. The closest histopathologic margin was compared with the in situ margin (10 mm) to determine and document any shrinkage of the margin and the percentage of discrepancy if any. Results: A total of 52 specimens were collected from patients between January 2014 and December 2014. All specimens were obtained from the oral cavity (n = 52) of which 43 (82.7%) were squamous cell carcinoma and 9 (17.3%) were verrucous variant of squamous cell carcinoma. The average decrease in tumor margins measured after fixation in formalin was found to be statistically significant (P < 0.05) in 65% of cases. Conclusion: Tumor margin shrinks significantly after formalin fixation by about 25%. The operating surgeon and pathologist should be well aware of such changes while planning for further management thereby ensuring adequate margin of resection and adjuvant treatment wherever required to prevent possible local recurrence of the disease. Keywords: Oral squamous cell carcinoma, Formalin fixation, Margin of resection, RecurrenceS.M. Azeem MohiyuddinB. Vageesh PadiyarT.N. SureshKouser MohammadiA. SagayarajShuaib MerchantMahnaaz Sultana AzeemKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 2, Iss 1, Pp 17-21 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 S.M. Azeem Mohiyuddin B. Vageesh Padiyar T.N. Suresh Kouser Mohammadi A. Sagayaraj Shuaib Merchant Mahnaaz Sultana Azeem Clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa
description	Objective: To evaluate the margins of resected specimen of oral squamous cell carcinoma (SCC) and to document the surgical margin (measured at the time of resection) and margins at the time of pathological examination (after immersion of the specimen in formalin). Methods: Patients who were diagnosed and confirmed with squamous carcinoma of buccal mucosa were included in the study. Patients underwent resection of the tumor with a margin of 1 cm. Soon after resection, the distance between outermost visible margin of the tumor and the margin of the specimen was measured and documented. Specimens were fixed in 10% formalin and submitted for gross and histopathological examination. The closest histopathologic margin was compared with the in situ margin (10 mm) to determine and document any shrinkage of the margin and the percentage of discrepancy if any. Results: A total of 52 specimens were collected from patients between January 2014 and December 2014. All specimens were obtained from the oral cavity (n = 52) of which 43 (82.7%) were squamous cell carcinoma and 9 (17.3%) were verrucous variant of squamous cell carcinoma. The average decrease in tumor margins measured after fixation in formalin was found to be statistically significant (P < 0.05) in 65% of cases. Conclusion: Tumor margin shrinks significantly after formalin fixation by about 25%. The operating surgeon and pathologist should be well aware of such changes while planning for further management thereby ensuring adequate margin of resection and adjuvant treatment wherever required to prevent possible local recurrence of the disease. Keywords: Oral squamous cell carcinoma, Formalin fixation, Margin of resection, Recurrence
format	article
author	S.M. Azeem Mohiyuddin B. Vageesh Padiyar T.N. Suresh Kouser Mohammadi A. Sagayaraj Shuaib Merchant Mahnaaz Sultana Azeem
author_facet	S.M. Azeem Mohiyuddin B. Vageesh Padiyar T.N. Suresh Kouser Mohammadi A. Sagayaraj Shuaib Merchant Mahnaaz Sultana Azeem
author_sort	S.M. Azeem Mohiyuddin
title	Clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa
title_short	Clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa
title_full	Clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa
title_fullStr	Clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa
title_full_unstemmed	Clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa
title_sort	clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/1e6164903653445998cecc44ea365323
work_keys_str_mv	AT smazeemmohiyuddin clinicopathologicalstudyofsurgicalmarginsinsquamouscellcarcinomaofbuccalmucosa AT bvageeshpadiyar clinicopathologicalstudyofsurgicalmarginsinsquamouscellcarcinomaofbuccalmucosa AT tnsuresh clinicopathologicalstudyofsurgicalmarginsinsquamouscellcarcinomaofbuccalmucosa AT kousermohammadi clinicopathologicalstudyofsurgicalmarginsinsquamouscellcarcinomaofbuccalmucosa AT asagayaraj clinicopathologicalstudyofsurgicalmarginsinsquamouscellcarcinomaofbuccalmucosa AT shuaibmerchant clinicopathologicalstudyofsurgicalmarginsinsquamouscellcarcinomaofbuccalmucosa AT mahnaazsultanaazeem clinicopathologicalstudyofsurgicalmarginsinsquamouscellcarcinomaofbuccalmucosa
_version_	1718395212706873344

Clinicopathological study of surgical margins in squamous cell carcinoma of buccal mucosa

Ejemplares similares