Correlation Study of Galectin-3 in Patients with an Ascending Aortic Aneurysm and Ventricular Remodeling Before and After Surgical Correction

Jian-Jun Gu, Zhi-Hong Cheng, Ji-Qiang Bu, Wen-Li Zhang, Li-Hua Chen, Zi-Ying Chen Department of Cardiac Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of ChinaCorrespondence: Zi-Ying ChenDepartment of Cardiac Surgery, The Second Hospital of H...

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Autores principales:	Gu JJ, Cheng ZH, Bu JQ, Zhang WL, Chen LH, Chen ZY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ascending aortic aneurysm ventricular remodeling galectin-3 left ventricular mass index ascending aortic replacement Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1e63f36da03748ad8e262c0dacae76e9
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spelling	oai:doaj.org-article:1e63f36da03748ad8e262c0dacae76e92021-11-30T18:50:36ZCorrelation Study of Galectin-3 in Patients with an Ascending Aortic Aneurysm and Ventricular Remodeling Before and After Surgical Correction1178-7074https://doaj.org/article/1e63f36da03748ad8e262c0dacae76e92021-11-01T00:00:00Zhttps://www.dovepress.com/correlation-study-of-galectin-3-in-patients-with-an-ascending-aortic-a-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Jian-Jun Gu, Zhi-Hong Cheng, Ji-Qiang Bu, Wen-Li Zhang, Li-Hua Chen, Zi-Ying Chen Department of Cardiac Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of ChinaCorrespondence: Zi-Ying ChenDepartment of Cardiac Surgery, The Second Hospital of Hebei Medical University, No. 215, Heping Road, Shijiazhuang, Hebei, 050000, People’s Republic of ChinaTel +86 15803210520Email ziyingchen_dr06@163.comObjective: The present study aims to observe the changes in galectin-3 (Gal-3) expression levels in patients with an ascending aortic aneurysm and ventricular remodeling and analyze Gal-3’s correlation with ventricular remodeling.Methods: A total of 102 patients with an ascending aortic aneurysm were included as the research subjects. Gal-3 expression levels in the peripheral blood of the patients were detected by an enzyme-linked immunosorbent assay before the operation and then three and six months after. The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), interventricular septal thickness, and left ventricular posterior wall thickness were recorded, and the left ventricular mass index (LVMI) was calculated. Changes in Gal-3 expression levels, LVMI, LVEF, and LVEDD were observed before and after surgery, and these changes were then analyzed.Results: There were significant differences in Gal-3 expression levels, LVMI, and LVEDD before surgery and three months after (P < 0.001) but no significant difference in LVEF (P = 0.887). There were significant differences in Gal-3 expression levels, LVMI, LVEDD, and LVEF (P < 0.05) three and six months after surgery. Before surgery and three and six months after surgery, Gal-3 was positively correlated with LVMI and LVEDD (R = 0.697, R = 0.571, and R = 0.454, respectively), and a receiver operating characteristic curve found that Gal-3 was able to predict ventricular remodeling, with an area under the curve value of 0.721.Conclusion: Gal-3 expression levels are correlated with ascending aortic aneurysms combined with ventricular remodeling, which provides a reference value for predicting ventricular remodeling.Keywords: ascending aortic aneurysm, ventricular remodeling, galectin-3, left ventricular mass index, ascending aortic replacementGu JJCheng ZHBu JQZhang WLChen LHChen ZYDove Medical Pressarticleascending aortic aneurysmventricular remodelinggalectin-3left ventricular mass indexascending aortic replacementMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 9001-9006 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ascending aortic aneurysm ventricular remodeling galectin-3 left ventricular mass index ascending aortic replacement Medicine (General) R5-920
spellingShingle	ascending aortic aneurysm ventricular remodeling galectin-3 left ventricular mass index ascending aortic replacement Medicine (General) R5-920 Gu JJ Cheng ZH Bu JQ Zhang WL Chen LH Chen ZY Correlation Study of Galectin-3 in Patients with an Ascending Aortic Aneurysm and Ventricular Remodeling Before and After Surgical Correction
description	Jian-Jun Gu, Zhi-Hong Cheng, Ji-Qiang Bu, Wen-Li Zhang, Li-Hua Chen, Zi-Ying Chen Department of Cardiac Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of ChinaCorrespondence: Zi-Ying ChenDepartment of Cardiac Surgery, The Second Hospital of Hebei Medical University, No. 215, Heping Road, Shijiazhuang, Hebei, 050000, People’s Republic of ChinaTel +86 15803210520Email ziyingchen_dr06@163.comObjective: The present study aims to observe the changes in galectin-3 (Gal-3) expression levels in patients with an ascending aortic aneurysm and ventricular remodeling and analyze Gal-3’s correlation with ventricular remodeling.Methods: A total of 102 patients with an ascending aortic aneurysm were included as the research subjects. Gal-3 expression levels in the peripheral blood of the patients were detected by an enzyme-linked immunosorbent assay before the operation and then three and six months after. The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), interventricular septal thickness, and left ventricular posterior wall thickness were recorded, and the left ventricular mass index (LVMI) was calculated. Changes in Gal-3 expression levels, LVMI, LVEF, and LVEDD were observed before and after surgery, and these changes were then analyzed.Results: There were significant differences in Gal-3 expression levels, LVMI, and LVEDD before surgery and three months after (P < 0.001) but no significant difference in LVEF (P = 0.887). There were significant differences in Gal-3 expression levels, LVMI, LVEDD, and LVEF (P < 0.05) three and six months after surgery. Before surgery and three and six months after surgery, Gal-3 was positively correlated with LVMI and LVEDD (R = 0.697, R = 0.571, and R = 0.454, respectively), and a receiver operating characteristic curve found that Gal-3 was able to predict ventricular remodeling, with an area under the curve value of 0.721.Conclusion: Gal-3 expression levels are correlated with ascending aortic aneurysms combined with ventricular remodeling, which provides a reference value for predicting ventricular remodeling.Keywords: ascending aortic aneurysm, ventricular remodeling, galectin-3, left ventricular mass index, ascending aortic replacement
format	article
author	Gu JJ Cheng ZH Bu JQ Zhang WL Chen LH Chen ZY
author_facet	Gu JJ Cheng ZH Bu JQ Zhang WL Chen LH Chen ZY
author_sort	Gu JJ
title	Correlation Study of Galectin-3 in Patients with an Ascending Aortic Aneurysm and Ventricular Remodeling Before and After Surgical Correction
title_short	Correlation Study of Galectin-3 in Patients with an Ascending Aortic Aneurysm and Ventricular Remodeling Before and After Surgical Correction
title_full	Correlation Study of Galectin-3 in Patients with an Ascending Aortic Aneurysm and Ventricular Remodeling Before and After Surgical Correction
title_fullStr	Correlation Study of Galectin-3 in Patients with an Ascending Aortic Aneurysm and Ventricular Remodeling Before and After Surgical Correction
title_full_unstemmed	Correlation Study of Galectin-3 in Patients with an Ascending Aortic Aneurysm and Ventricular Remodeling Before and After Surgical Correction
title_sort	correlation study of galectin-3 in patients with an ascending aortic aneurysm and ventricular remodeling before and after surgical correction
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1e63f36da03748ad8e262c0dacae76e9
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Correlation Study of Galectin-3 in Patients with an Ascending Aortic Aneurysm and Ventricular Remodeling Before and After Surgical Correction

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