Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats

Background: The organic composite of two phenolic neighbors [BPA] is Bisphenol A [BPA]. It is also commonly called propane 2,2 bis[4-hydroxyphenyl]. BPA is a voluminous industrial chemical used to manufacture epoxy resins and plastics. Aim of the work: Evaluation of the effect of oral Bisphenol A o...

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Autores principales:	Mohamed Ali Mahmoud Abbas, Samir Atef Farid Elmetwally, Mokhtar Ahmed Mokhtar Abo-Elfotoh
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	bisphenol a liver kidney adult male albino rats Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1e697daf72ed40e2aaa20ee999c04fc9
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spelling	oai:doaj.org-article:1e697daf72ed40e2aaa20ee999c04fc92021-12-02T14:33:24ZEffect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats2636-41742682-378010.21608/ijma.2020.37970.1152https://doaj.org/article/1e697daf72ed40e2aaa20ee999c04fc92021-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_112383_29fe262ed57c726dbc9aa54b3113c8ce.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: The organic composite of two phenolic neighbors [BPA] is Bisphenol A [BPA]. It is also commonly called propane 2,2 bis[4-hydroxyphenyl]. BPA is a voluminous industrial chemical used to manufacture epoxy resins and plastics. Aim of the work: Evaluation of the effect of oral Bisphenol A on the liver and kidney of adult male albino rats. Materials and Methods: Forty adult male albino rats [local strain] were divided into four groups [each 10 rats]. First is the control group, second is the low does BPA, third is moderate does BPA, and four is the high does BPA. The duration of exposure extended to 30 days. Then, blood samples have been collected for the measurement of serum aspartate aminotransferase [AST], serum alanine aminotransferase [ALT], blood urea, serum creatinine, superoxide dismutase [SOD], catalase, and glutathione. Also, hepatic and renal tissue samples were prepared for histopathological study. Results: Oral administration of BPA in a dose of 50, 100, and 150 Mg/kg/day for 30 days led to a significant increase in the blood levels of ALT, AST, urea, and creatinine associated with a significant reduction in the blood levels of superoxide dismutase, Glutathione peroxidase, and catalase. There were few vacuolations of hepatocytes and congested blood vessels of the liver that were associated with changes in the kidney [narrow cortex, dilated tubules, and hypercellular glomeruli]. Conclusion: Bisphenol A oral exposure for 30 consecutive days is associated with several changes in biochemical parameters that indicate liver and kidney injury.Mohamed Ali Mahmoud AbbasSamir Atef Farid ElmetwallyMokhtar Ahmed Mokhtar Abo-ElfotohAl-Azhar University, Faculty of Medicine (Damietta)articlebisphenol aliverkidneyadult malealbino ratsMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 1, Pp 930-937 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bisphenol a liver kidney adult male albino rats Medicine (General) R5-920
spellingShingle	bisphenol a liver kidney adult male albino rats Medicine (General) R5-920 Mohamed Ali Mahmoud Abbas Samir Atef Farid Elmetwally Mokhtar Ahmed Mokhtar Abo-Elfotoh Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats
description	Background: The organic composite of two phenolic neighbors [BPA] is Bisphenol A [BPA]. It is also commonly called propane 2,2 bis[4-hydroxyphenyl]. BPA is a voluminous industrial chemical used to manufacture epoxy resins and plastics. Aim of the work: Evaluation of the effect of oral Bisphenol A on the liver and kidney of adult male albino rats. Materials and Methods: Forty adult male albino rats [local strain] were divided into four groups [each 10 rats]. First is the control group, second is the low does BPA, third is moderate does BPA, and four is the high does BPA. The duration of exposure extended to 30 days. Then, blood samples have been collected for the measurement of serum aspartate aminotransferase [AST], serum alanine aminotransferase [ALT], blood urea, serum creatinine, superoxide dismutase [SOD], catalase, and glutathione. Also, hepatic and renal tissue samples were prepared for histopathological study. Results: Oral administration of BPA in a dose of 50, 100, and 150 Mg/kg/day for 30 days led to a significant increase in the blood levels of ALT, AST, urea, and creatinine associated with a significant reduction in the blood levels of superoxide dismutase, Glutathione peroxidase, and catalase. There were few vacuolations of hepatocytes and congested blood vessels of the liver that were associated with changes in the kidney [narrow cortex, dilated tubules, and hypercellular glomeruli]. Conclusion: Bisphenol A oral exposure for 30 consecutive days is associated with several changes in biochemical parameters that indicate liver and kidney injury.
format	article
author	Mohamed Ali Mahmoud Abbas Samir Atef Farid Elmetwally Mokhtar Ahmed Mokhtar Abo-Elfotoh
author_facet	Mohamed Ali Mahmoud Abbas Samir Atef Farid Elmetwally Mokhtar Ahmed Mokhtar Abo-Elfotoh
author_sort	Mohamed Ali Mahmoud Abbas
title	Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats
title_short	Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats
title_full	Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats
title_fullStr	Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats
title_full_unstemmed	Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats
title_sort	effect of oral exposure to bisphenol a on the liver and kidney of adult male albino rats
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/1e697daf72ed40e2aaa20ee999c04fc9
work_keys_str_mv	AT mohamedalimahmoudabbas effectoforalexposuretobisphenolaontheliverandkidneyofadultmalealbinorats AT samirateffaridelmetwally effectoforalexposuretobisphenolaontheliverandkidneyofadultmalealbinorats AT mokhtarahmedmokhtaraboelfotoh effectoforalexposuretobisphenolaontheliverandkidneyofadultmalealbinorats
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Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats

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