Antioxidant and Elastase Inhibitor from Black Soybean (Glycine max L.) and Its Compound (Daidzein)

Background: Skin aging occurs along with age. Genetic, nutrients, hormones, and sun exposure can affect directly and indirectly the structure of the skin. These things will induce an increase in free radicals which disrupts one of the most important enzymes in the extracellular matrix which is elast...

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Autores principales:	Cendy Juliana, I Nyoman Ehrich Lister, Ermi Girsang, Ali Napiah Nasution, Wahyu Widowati
Formato:	article
Lenguaje:	EN
Publicado:	Diponegoro University 2020
Materias:	black soybean daidzein antioxidant anti-aging anti-elastase Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1e6e7d8f17b44cbdb88fdc0aed13c5dc
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spelling	oai:doaj.org-article:1e6e7d8f17b44cbdb88fdc0aed13c5dc2021-11-05T16:47:33ZAntioxidant and Elastase Inhibitor from Black Soybean (Glycine max L.) and Its Compound (Daidzein)2503-217810.14710/jbtr.v6i1.5540https://doaj.org/article/1e6e7d8f17b44cbdb88fdc0aed13c5dc2020-04-01T00:00:00Zhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/5540https://doaj.org/toc/2503-2178Background: Skin aging occurs along with age. Genetic, nutrients, hormones, and sun exposure can affect directly and indirectly the structure of the skin. These things will induce an increase in free radicals which disrupts one of the most important enzymes in the extracellular matrix which is elastase enzyme. High enzyme synthesis will cause skin wrinkle. Free radicals can be inhibited by the presence of antioxidants. The plant contains natural phytochemical compounds which act as antioxidants and anti aging. Black soybeans are rich in daidzein compound, which protect against free radicals and prevent premature aging. Objective: This research evaluates the antioxidant and antiaging potential of Black Soybean (Glycine max L.) extract and its compound, daidzein. Methods: Analysis of antioxidants from black soybean extract and daidzein were carried out using ABTS scavenging activity assay. The antiaging assay was carried out through inhibition of elastase enzyme. Results: Black soybean extract had lower IC50 value of ABTS scavenging activity around 77.39±4.05 μg/ml better than daidzein with IC50 of 83.34±3.89 μg/ml. The results of elastase inhibition activity assay showed that daidzein compound has a lower IC50 value, 57.35±5.64 μg/ml compared to black soybean extract with IC50 value, 93.36±6.39 μg/ml. Conclusion: Black soybean extract had higher antioxidant. Daidzein had better elastase inhibition activity compared to black soybean extract.Cendy JulianaI Nyoman Ehrich ListerErmi GirsangAli Napiah NasutionWahyu WidowatiDiponegoro Universityarticleblack soybeandaidzeinantioxidantanti-aginganti-elastaseMedicine (General)R5-920ENJournal of Biomedicine and Translational Research, Vol 6, Iss 1, Pp 11-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	black soybean daidzein antioxidant anti-aging anti-elastase Medicine (General) R5-920
spellingShingle	black soybean daidzein antioxidant anti-aging anti-elastase Medicine (General) R5-920 Cendy Juliana I Nyoman Ehrich Lister Ermi Girsang Ali Napiah Nasution Wahyu Widowati Antioxidant and Elastase Inhibitor from Black Soybean (Glycine max L.) and Its Compound (Daidzein)
description	Background: Skin aging occurs along with age. Genetic, nutrients, hormones, and sun exposure can affect directly and indirectly the structure of the skin. These things will induce an increase in free radicals which disrupts one of the most important enzymes in the extracellular matrix which is elastase enzyme. High enzyme synthesis will cause skin wrinkle. Free radicals can be inhibited by the presence of antioxidants. The plant contains natural phytochemical compounds which act as antioxidants and anti aging. Black soybeans are rich in daidzein compound, which protect against free radicals and prevent premature aging. Objective: This research evaluates the antioxidant and antiaging potential of Black Soybean (Glycine max L.) extract and its compound, daidzein. Methods: Analysis of antioxidants from black soybean extract and daidzein were carried out using ABTS scavenging activity assay. The antiaging assay was carried out through inhibition of elastase enzyme. Results: Black soybean extract had lower IC50 value of ABTS scavenging activity around 77.39±4.05 μg/ml better than daidzein with IC50 of 83.34±3.89 μg/ml. The results of elastase inhibition activity assay showed that daidzein compound has a lower IC50 value, 57.35±5.64 μg/ml compared to black soybean extract with IC50 value, 93.36±6.39 μg/ml. Conclusion: Black soybean extract had higher antioxidant. Daidzein had better elastase inhibition activity compared to black soybean extract.
format	article
author	Cendy Juliana I Nyoman Ehrich Lister Ermi Girsang Ali Napiah Nasution Wahyu Widowati
author_facet	Cendy Juliana I Nyoman Ehrich Lister Ermi Girsang Ali Napiah Nasution Wahyu Widowati
author_sort	Cendy Juliana
title	Antioxidant and Elastase Inhibitor from Black Soybean (Glycine max L.) and Its Compound (Daidzein)
title_short	Antioxidant and Elastase Inhibitor from Black Soybean (Glycine max L.) and Its Compound (Daidzein)
title_full	Antioxidant and Elastase Inhibitor from Black Soybean (Glycine max L.) and Its Compound (Daidzein)
title_fullStr	Antioxidant and Elastase Inhibitor from Black Soybean (Glycine max L.) and Its Compound (Daidzein)
title_full_unstemmed	Antioxidant and Elastase Inhibitor from Black Soybean (Glycine max L.) and Its Compound (Daidzein)
title_sort	antioxidant and elastase inhibitor from black soybean (glycine max l.) and its compound (daidzein)
publisher	Diponegoro University
publishDate	2020
url	https://doaj.org/article/1e6e7d8f17b44cbdb88fdc0aed13c5dc
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Antioxidant and Elastase Inhibitor from Black Soybean (Glycine max L.) and Its Compound (Daidzein)

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