The NADase-Negative Variant of the <named-content content-type="genus-species">Streptococcus pyogenes</named-content> Toxin NAD<sup>+</sup> Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis

The NADase-Negative Variant of the <named-content content-type="genus-species">Streptococcus pyogenes</named-content> Toxin NAD<sup>+</sup> Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis

ABSTRACT Virulence factors are often multifunctional and contribute to pathogenesis through synergistic mechanisms. For the human pathogen Streptococcus pyogenes, two factors that act synergistically are the S. pyogenes NAD+ glycohydrolase (SPN) and streptolysin O (SLO). Through distinct mechanisms,...

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Autores principales: Sukantha Chandrasekaran, Michael G. Caparon
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2016
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/1e73204988fb4d9f93cfc11cc40a0988
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