EFFECTS OF AN EIGHT-WEEK ATORVASTATIN TREATMENT ON SPONTANEOUS CYTOKINE PRODUCTION BY THE BLOOD MONONUCLEAR LEUKOCYTES IN METABOLIC SYNDROME

The aim of this study was to assess effects of the eight-week course of atorvastatin therapy upon the levels of spontaneous cytokine production by mononuclear blood leukocytes (MNBC) in metabolic syndrome. An open-label prospective study included 36 patients with stage II hypertension (blood pressur...

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Autores principales:	I. D. Bespalovа, N. V. Ryazantseva, V. V. Kalyuzhin, B. Yu. Murashev, I. A. Osikhov, Yu. A. Medyantsev, D. S. Afanas’eva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	metabolic syndrome inflammatory markers cytokines atorvastatin Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1e76b76a9889448cace5973beac1beb4
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spelling	oai:doaj.org-article:1e76b76a9889448cace5973beac1beb42021-11-18T08:03:44ZEFFECTS OF AN EIGHT-WEEK ATORVASTATIN TREATMENT ON SPONTANEOUS CYTOKINE PRODUCTION BY THE BLOOD MONONUCLEAR LEUKOCYTES IN METABOLIC SYNDROME1563-06252313-741X10.15789/1563-0625-2014-5-481-186https://doaj.org/article/1e76b76a9889448cace5973beac1beb42014-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/736https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of this study was to assess effects of the eight-week course of atorvastatin therapy upon the levels of spontaneous cytokine production by mononuclear blood leukocytes (MNBC) in metabolic syndrome. An open-label prospective study included 36 patients with stage II hypertension (blood pressure < 180/110 mm Hg.) accomplished by metabolic syndrome. Along with clinical surveys performed at a specialized cardiological clinics, we assessed spontaneous cytokine production by MNBC during treatment with atorvastatin. It was shown that the 8-week treatment of these patients with atorvaststin, at individually matched daily doses (20to 40 mg) was associated with reduced serum concentration of acute phase proteins (C-reactive protein and neopterin), as well as decreased spontaneous production of proinflammatory cytokines (IL-1β, IL-6 and TNFα) by MNBCs. The latter finding is of great importance for pathogenesis of metabolic syndrome.I. D. BespalovаN. V. RyazantsevaV. V. KalyuzhinB. Yu. MurashevI. A. OsikhovYu. A. MedyantsevD. S. Afanas’evaSPb RAACIarticlemetabolic syndromeinflammatory markerscytokinesatorvastatinImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 5, Pp 481-186 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	metabolic syndrome inflammatory markers cytokines atorvastatin Immunologic diseases. Allergy RC581-607
spellingShingle	metabolic syndrome inflammatory markers cytokines atorvastatin Immunologic diseases. Allergy RC581-607 I. D. Bespalovа N. V. Ryazantseva V. V. Kalyuzhin B. Yu. Murashev I. A. Osikhov Yu. A. Medyantsev D. S. Afanas’eva EFFECTS OF AN EIGHT-WEEK ATORVASTATIN TREATMENT ON SPONTANEOUS CYTOKINE PRODUCTION BY THE BLOOD MONONUCLEAR LEUKOCYTES IN METABOLIC SYNDROME
description	The aim of this study was to assess effects of the eight-week course of atorvastatin therapy upon the levels of spontaneous cytokine production by mononuclear blood leukocytes (MNBC) in metabolic syndrome. An open-label prospective study included 36 patients with stage II hypertension (blood pressure < 180/110 mm Hg.) accomplished by metabolic syndrome. Along with clinical surveys performed at a specialized cardiological clinics, we assessed spontaneous cytokine production by MNBC during treatment with atorvastatin. It was shown that the 8-week treatment of these patients with atorvaststin, at individually matched daily doses (20to 40 mg) was associated with reduced serum concentration of acute phase proteins (C-reactive protein and neopterin), as well as decreased spontaneous production of proinflammatory cytokines (IL-1β, IL-6 and TNFα) by MNBCs. The latter finding is of great importance for pathogenesis of metabolic syndrome.
format	article
author	I. D. Bespalovа N. V. Ryazantseva V. V. Kalyuzhin B. Yu. Murashev I. A. Osikhov Yu. A. Medyantsev D. S. Afanas’eva
author_facet	I. D. Bespalovа N. V. Ryazantseva V. V. Kalyuzhin B. Yu. Murashev I. A. Osikhov Yu. A. Medyantsev D. S. Afanas’eva
author_sort	I. D. Bespalovа
title	EFFECTS OF AN EIGHT-WEEK ATORVASTATIN TREATMENT ON SPONTANEOUS CYTOKINE PRODUCTION BY THE BLOOD MONONUCLEAR LEUKOCYTES IN METABOLIC SYNDROME
title_short	EFFECTS OF AN EIGHT-WEEK ATORVASTATIN TREATMENT ON SPONTANEOUS CYTOKINE PRODUCTION BY THE BLOOD MONONUCLEAR LEUKOCYTES IN METABOLIC SYNDROME
title_full	EFFECTS OF AN EIGHT-WEEK ATORVASTATIN TREATMENT ON SPONTANEOUS CYTOKINE PRODUCTION BY THE BLOOD MONONUCLEAR LEUKOCYTES IN METABOLIC SYNDROME
title_fullStr	EFFECTS OF AN EIGHT-WEEK ATORVASTATIN TREATMENT ON SPONTANEOUS CYTOKINE PRODUCTION BY THE BLOOD MONONUCLEAR LEUKOCYTES IN METABOLIC SYNDROME
title_full_unstemmed	EFFECTS OF AN EIGHT-WEEK ATORVASTATIN TREATMENT ON SPONTANEOUS CYTOKINE PRODUCTION BY THE BLOOD MONONUCLEAR LEUKOCYTES IN METABOLIC SYNDROME
title_sort	effects of an eight-week atorvastatin treatment on spontaneous cytokine production by the blood mononuclear leukocytes in metabolic syndrome
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1e76b76a9889448cace5973beac1beb4
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EFFECTS OF AN EIGHT-WEEK ATORVASTATIN TREATMENT ON SPONTANEOUS CYTOKINE PRODUCTION BY THE BLOOD MONONUCLEAR LEUKOCYTES IN METABOLIC SYNDROME

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