Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery

Yanhui Jia1, Mei Yuan1, Huidong Yuan1, Xinglu Huang2, Xiang Sui1, Xuemei Cui1, Fangqiong Tang2, Jiang Peng1, Jiying Chen1, Shibi Lu1, Wenjing Xu1, Li Zhang1, Quanyi Guo11Institute of Orthopedics, General Hospital of the Chinese People&#39;s Liberation Army, Beijing, People&#39;s Repu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jia Y, Yuan M, Yuan H, Huang X, Sui X, Cui X, Tang F, Peng J, Chen J, Lu S, Xu W, Zhang L, Guo Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1e7750e870cc4e1db299f1815c4bd739
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1e7750e870cc4e1db299f1815c4bd739
record_format	dspace
spelling	oai:doaj.org-article:1e7750e870cc4e1db299f1815c4bd7392021-12-02T08:08:31ZCo-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery1176-91141178-2013https://doaj.org/article/1e7750e870cc4e1db299f1815c4bd7392012-03-01T00:00:00Zhttp://www.dovepress.com/co-encapsulation-of-magnetic-fe3o4-nanoparticles-and-doxorubicin-into--a9592https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yanhui Jia1, Mei Yuan1, Huidong Yuan1, Xinglu Huang2, Xiang Sui1, Xuemei Cui1, Fangqiong Tang2, Jiang Peng1, Jiying Chen1, Shibi Lu1, Wenjing Xu1, Li Zhang1, Quanyi Guo11Institute of Orthopedics, General Hospital of the Chinese People&#39;s Liberation Army, Beijing, People&#39;s Republic of China; 2Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, People&#39;s Republic of ChinaAbstract: In this study, the authors constructed a novel PLGA [poly(D,L-lactic-co-glycolic acid)]-based polymeric nanocarrier co-encapsulated with doxorubicin (DOX) and magnetic Fe3O4 nanoparticles (MNPs) using a single emulsion evaporation method. The DOX-MNPs showed high entrapment efficiency, and they supported a sustained and steady release of DOX. Moreover, the drug release was pH sensitive, with a faster release rate in an acidic environment than in a neutral environment. In vitro, the DOX-MNPs were easily internalized into murine Lewis lung carcinoma cells and they induced apoptosis. In vivo, the DOX-MNPs showed higher antitumor activity than free DOX solution. Furthermore, the antitumor activity of the DOX-MNPs was higher with than without an external magnetic field; they were also associated with smaller tumor volume and a lower metastases incidence rate. This work may provide a new modality for developing an effective drug delivery system.Keywords: antitumor activity, external magnetic field, intratumoral injection, apoptosis, Lewis lung carcinomaJia YYuan MYuan HHuang XSui XCui XTang FPeng JChen JLu SXu WZhang LGuo QDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1697-1708 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jia Y Yuan M Yuan H Huang X Sui X Cui X Tang F Peng J Chen J Lu S Xu W Zhang L Guo Q Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery
description	Yanhui Jia1, Mei Yuan1, Huidong Yuan1, Xinglu Huang2, Xiang Sui1, Xuemei Cui1, Fangqiong Tang2, Jiang Peng1, Jiying Chen1, Shibi Lu1, Wenjing Xu1, Li Zhang1, Quanyi Guo11Institute of Orthopedics, General Hospital of the Chinese People&#39;s Liberation Army, Beijing, People&#39;s Republic of China; 2Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, People&#39;s Republic of ChinaAbstract: In this study, the authors constructed a novel PLGA [poly(D,L-lactic-co-glycolic acid)]-based polymeric nanocarrier co-encapsulated with doxorubicin (DOX) and magnetic Fe3O4 nanoparticles (MNPs) using a single emulsion evaporation method. The DOX-MNPs showed high entrapment efficiency, and they supported a sustained and steady release of DOX. Moreover, the drug release was pH sensitive, with a faster release rate in an acidic environment than in a neutral environment. In vitro, the DOX-MNPs were easily internalized into murine Lewis lung carcinoma cells and they induced apoptosis. In vivo, the DOX-MNPs showed higher antitumor activity than free DOX solution. Furthermore, the antitumor activity of the DOX-MNPs was higher with than without an external magnetic field; they were also associated with smaller tumor volume and a lower metastases incidence rate. This work may provide a new modality for developing an effective drug delivery system.Keywords: antitumor activity, external magnetic field, intratumoral injection, apoptosis, Lewis lung carcinoma
format	article
author	Jia Y Yuan M Yuan H Huang X Sui X Cui X Tang F Peng J Chen J Lu S Xu W Zhang L Guo Q
author_facet	Jia Y Yuan M Yuan H Huang X Sui X Cui X Tang F Peng J Chen J Lu S Xu W Zhang L Guo Q
author_sort	Jia Y
title	Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery
title_short	Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery
title_full	Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery
title_fullStr	Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery
title_full_unstemmed	Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery
title_sort	co-encapsulation of magnetic fe3o4 nanoparticles and doxorubicin into biodegradable plga nanocarriers for intratumoral drug delivery
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/1e7750e870cc4e1db299f1815c4bd739
work_keys_str_mv	AT jiay coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT yuanm coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT yuanh coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT huangx coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT suix coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT cuix coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT tangf coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT pengj coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT chenj coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT lus coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT xuw coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT zhangl coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery AT guoq coencapsulationofmagneticfe3o4nanoparticlesanddoxorubicinintobiodegradableplgananocarriersforintratumoraldrugdelivery
_version_	1718398589132079104

Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery

Ejemplares similares