Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma

Photodynamic therapy has shown promise in the treatment of early head and neck squamous cell carcinoma (SCC). In photodynamic therapy (PDT), a light sensitive drug (photosensitizer) and visible light cause cancer cell death by the creation of singlet oxygen and free radicals, inciting an immune resp...

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Autores principales:	Christina Mimikos, Gal Shafirstein, Hassan Arshad
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/1e79123513c3418a8226bf629fa1c543
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spelling	oai:doaj.org-article:1e79123513c3418a8226bf629fa1c5432021-12-02T14:18:17ZCurrent state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma2095-881110.1016/j.wjorl.2016.05.011https://doaj.org/article/1e79123513c3418a8226bf629fa1c5432016-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881116300130https://doaj.org/toc/2095-8811Photodynamic therapy has shown promise in the treatment of early head and neck squamous cell carcinoma (SCC). In photodynamic therapy (PDT), a light sensitive drug (photosensitizer) and visible light cause cancer cell death by the creation of singlet oxygen and free radicals, inciting an immune response, and vascular collapse. In this paper, we review several studies that demonstrate the effectiveness of PDT in the treatment of early stage SCC of the head and neck, with some showing a similar response rate to surgery. Two cases are presented to illustrate the effectiveness of PDT. Then, new advances are discussed including the discovery of STAT3 crosslinking as a potential biomarker for PDT response and interstitial PDT for locally advanced cancers. Keywords: Photodynamic therapy, PDT, Squamous cell carcinoma, Head and neck cancerChristina MimikosGal ShafirsteinHassan ArshadKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 2, Iss 2, Pp 126-129 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Christina Mimikos Gal Shafirstein Hassan Arshad Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma
description	Photodynamic therapy has shown promise in the treatment of early head and neck squamous cell carcinoma (SCC). In photodynamic therapy (PDT), a light sensitive drug (photosensitizer) and visible light cause cancer cell death by the creation of singlet oxygen and free radicals, inciting an immune response, and vascular collapse. In this paper, we review several studies that demonstrate the effectiveness of PDT in the treatment of early stage SCC of the head and neck, with some showing a similar response rate to surgery. Two cases are presented to illustrate the effectiveness of PDT. Then, new advances are discussed including the discovery of STAT3 crosslinking as a potential biomarker for PDT response and interstitial PDT for locally advanced cancers. Keywords: Photodynamic therapy, PDT, Squamous cell carcinoma, Head and neck cancer
format	article
author	Christina Mimikos Gal Shafirstein Hassan Arshad
author_facet	Christina Mimikos Gal Shafirstein Hassan Arshad
author_sort	Christina Mimikos
title	Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma
title_short	Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma
title_full	Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma
title_fullStr	Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma
title_full_unstemmed	Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma
title_sort	current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/1e79123513c3418a8226bf629fa1c543
work_keys_str_mv	AT christinamimikos currentstateandfutureofphotodynamictherapyforthetreatmentofheadandnecksquamouscellcarcinoma AT galshafirstein currentstateandfutureofphotodynamictherapyforthetreatmentofheadandnecksquamouscellcarcinoma AT hassanarshad currentstateandfutureofphotodynamictherapyforthetreatmentofheadandnecksquamouscellcarcinoma
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Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma

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