Investigation of 6-[¹⁸F]-fluoromaltose as a novel PET tracer for imaging bacterial infection.

<h4>Unlabelled</h4>Despite advances in the field of nuclear medicine, the imaging of bacterial infections has remained a challenge. The existing reagents suffer from poor sensitivity and specificity. In this study we investigate the potential of a novel PET (positron emission tomography)...

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Autores principales:	Gayatri Gowrishankar, Mohammad Namavari, Erwan Benjamin Jouannot, Aileen Hoehne, Robert Reeves, Jonathan Hardy, Sanjiv Sam Gambhir
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e7e882be56d405298d4824390095111
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spelling	oai:doaj.org-article:1e7e882be56d405298d48243900951112021-11-25T05:59:52ZInvestigation of 6-[¹⁸F]-fluoromaltose as a novel PET tracer for imaging bacterial infection.1932-620310.1371/journal.pone.0107951https://doaj.org/article/1e7e882be56d405298d48243900951112014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0107951https://doaj.org/toc/1932-6203<h4>Unlabelled</h4>Despite advances in the field of nuclear medicine, the imaging of bacterial infections has remained a challenge. The existing reagents suffer from poor sensitivity and specificity. In this study we investigate the potential of a novel PET (positron emission tomography) tracer that overcomes these limitations.<h4>Methods</h4>6-[¹⁸F]-fluoromaltose was synthesized. Its behavior in vitro was evaluated in bacterial and mammalian cultures. Detailed pharmacokinetic and biodistribution profiles for the tracer were obtained from a murine model.<h4>Results</h4>6-[¹⁸F]-fluoromaltose is taken up by multiple strains of pathogenic bacteria. It is not taken up by mammalian cancer cell lines. 6-[¹⁸F]-fluoromaltose is retained in infected muscles in a murine model of bacterial myositis. It does not accumulate in inflamed tissue.<h4>Conclusion</h4>We have shown that 6-[¹⁸F]-fluoromaltose can be used to image bacterial infection in vivo with high specificity. We believe that this class of agents will have a significant impact on the clinical management of patients.Gayatri GowrishankarMohammad NamavariErwan Benjamin JouannotAileen HoehneRobert ReevesJonathan HardySanjiv Sam GambhirPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e107951 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gayatri Gowrishankar Mohammad Namavari Erwan Benjamin Jouannot Aileen Hoehne Robert Reeves Jonathan Hardy Sanjiv Sam Gambhir Investigation of 6-[¹⁸F]-fluoromaltose as a novel PET tracer for imaging bacterial infection.
description	<h4>Unlabelled</h4>Despite advances in the field of nuclear medicine, the imaging of bacterial infections has remained a challenge. The existing reagents suffer from poor sensitivity and specificity. In this study we investigate the potential of a novel PET (positron emission tomography) tracer that overcomes these limitations.<h4>Methods</h4>6-[¹⁸F]-fluoromaltose was synthesized. Its behavior in vitro was evaluated in bacterial and mammalian cultures. Detailed pharmacokinetic and biodistribution profiles for the tracer were obtained from a murine model.<h4>Results</h4>6-[¹⁸F]-fluoromaltose is taken up by multiple strains of pathogenic bacteria. It is not taken up by mammalian cancer cell lines. 6-[¹⁸F]-fluoromaltose is retained in infected muscles in a murine model of bacterial myositis. It does not accumulate in inflamed tissue.<h4>Conclusion</h4>We have shown that 6-[¹⁸F]-fluoromaltose can be used to image bacterial infection in vivo with high specificity. We believe that this class of agents will have a significant impact on the clinical management of patients.
format	article
author	Gayatri Gowrishankar Mohammad Namavari Erwan Benjamin Jouannot Aileen Hoehne Robert Reeves Jonathan Hardy Sanjiv Sam Gambhir
author_facet	Gayatri Gowrishankar Mohammad Namavari Erwan Benjamin Jouannot Aileen Hoehne Robert Reeves Jonathan Hardy Sanjiv Sam Gambhir
author_sort	Gayatri Gowrishankar
title	Investigation of 6-[¹⁸F]-fluoromaltose as a novel PET tracer for imaging bacterial infection.
title_short	Investigation of 6-[¹⁸F]-fluoromaltose as a novel PET tracer for imaging bacterial infection.
title_full	Investigation of 6-[¹⁸F]-fluoromaltose as a novel PET tracer for imaging bacterial infection.
title_fullStr	Investigation of 6-[¹⁸F]-fluoromaltose as a novel PET tracer for imaging bacterial infection.
title_full_unstemmed	Investigation of 6-[¹⁸F]-fluoromaltose as a novel PET tracer for imaging bacterial infection.
title_sort	investigation of 6-[¹⁸f]-fluoromaltose as a novel pet tracer for imaging bacterial infection.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1e7e882be56d405298d4824390095111
work_keys_str_mv	AT gayatrigowrishankar investigationof618ffluoromaltoseasanovelpettracerforimagingbacterialinfection AT mohammadnamavari investigationof618ffluoromaltoseasanovelpettracerforimagingbacterialinfection AT erwanbenjaminjouannot investigationof618ffluoromaltoseasanovelpettracerforimagingbacterialinfection AT aileenhoehne investigationof618ffluoromaltoseasanovelpettracerforimagingbacterialinfection AT robertreeves investigationof618ffluoromaltoseasanovelpettracerforimagingbacterialinfection AT jonathanhardy investigationof618ffluoromaltoseasanovelpettracerforimagingbacterialinfection AT sanjivsamgambhir investigationof618ffluoromaltoseasanovelpettracerforimagingbacterialinfection
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Investigation of 6-[¹⁸F]-fluoromaltose as a novel PET tracer for imaging bacterial infection.

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