Research progress of gut microbiota and frailty syndrome

Frailty is a clinical syndrome caused by homeostasis imbalance. It is characterized by marked vulnerability to endogenous or exogenous stressors, reduced self-care ability, and increased mortality risk. This aging-related syndrome is common in individuals older than 65 years and carries an increased...

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Autores principales:	Wang Xiao, Wu Min
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	frailty gut microbiota chronic inflammation neurodegenerative diseases inflammatory factors Medicine R
Acceso en línea:	https://doaj.org/article/1e81d86fbe0c465082f89d6e97cc03bd
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spelling	oai:doaj.org-article:1e81d86fbe0c465082f89d6e97cc03bd2021-12-05T14:10:55ZResearch progress of gut microbiota and frailty syndrome2391-546310.1515/med-2021-0364https://doaj.org/article/1e81d86fbe0c465082f89d6e97cc03bd2021-10-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0364https://doaj.org/toc/2391-5463Frailty is a clinical syndrome caused by homeostasis imbalance. It is characterized by marked vulnerability to endogenous or exogenous stressors, reduced self-care ability, and increased mortality risk. This aging-related syndrome is common in individuals older than 65 years and carries an increased risk for poor health outcomes. These include falls, incident disability, incapacity, and mortality. In addition, it can result in a poor prognosis for other comorbidities. With the aging population, frailty increases the burden of adverse health outcomes. Studies on frailty are at their infancy. In addition, there is a lack of thorough understanding of its pathogenesis. Several studies have suggested that frailty is caused by chronic inflammation due to enhanced intestinal permeability following gut microbiota imbalance as well as pathogen-related antibodies entering the circulation system. These result in musculoskeletal system disorders and neurodegenerative diseases. However, this assumption has not been validated in large cohort-based studies. Several studies have suggested that inflammation is not the only cause of frailty. Hence, further studies are necessary to extend our understanding of its pathogenesis. This review summarizes the research findings in the field and expands on the possible role of the gut microbiota in frailty syndrome.Wang XiaoWu MinDe Gruyterarticlefrailtygut microbiotachronic inflammationneurodegenerative diseasesinflammatory factorsMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1525-1536 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	frailty gut microbiota chronic inflammation neurodegenerative diseases inflammatory factors Medicine R
spellingShingle	frailty gut microbiota chronic inflammation neurodegenerative diseases inflammatory factors Medicine R Wang Xiao Wu Min Research progress of gut microbiota and frailty syndrome
description	Frailty is a clinical syndrome caused by homeostasis imbalance. It is characterized by marked vulnerability to endogenous or exogenous stressors, reduced self-care ability, and increased mortality risk. This aging-related syndrome is common in individuals older than 65 years and carries an increased risk for poor health outcomes. These include falls, incident disability, incapacity, and mortality. In addition, it can result in a poor prognosis for other comorbidities. With the aging population, frailty increases the burden of adverse health outcomes. Studies on frailty are at their infancy. In addition, there is a lack of thorough understanding of its pathogenesis. Several studies have suggested that frailty is caused by chronic inflammation due to enhanced intestinal permeability following gut microbiota imbalance as well as pathogen-related antibodies entering the circulation system. These result in musculoskeletal system disorders and neurodegenerative diseases. However, this assumption has not been validated in large cohort-based studies. Several studies have suggested that inflammation is not the only cause of frailty. Hence, further studies are necessary to extend our understanding of its pathogenesis. This review summarizes the research findings in the field and expands on the possible role of the gut microbiota in frailty syndrome.
format	article
author	Wang Xiao Wu Min
author_facet	Wang Xiao Wu Min
author_sort	Wang Xiao
title	Research progress of gut microbiota and frailty syndrome
title_short	Research progress of gut microbiota and frailty syndrome
title_full	Research progress of gut microbiota and frailty syndrome
title_fullStr	Research progress of gut microbiota and frailty syndrome
title_full_unstemmed	Research progress of gut microbiota and frailty syndrome
title_sort	research progress of gut microbiota and frailty syndrome
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/1e81d86fbe0c465082f89d6e97cc03bd
work_keys_str_mv	AT wangxiao researchprogressofgutmicrobiotaandfrailtysyndrome AT wumin researchprogressofgutmicrobiotaandfrailtysyndrome
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Research progress of gut microbiota and frailty syndrome

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