Association between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom

Background: Little is known on the potential relationship between osteoarthritis and Parkinson’s disease. Objective: Therefore, the objective of this retrospective cohort study was to analyze the association between osteoarthritis and the incidence of Parkinson’s disease in patients followed up for...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Louis Jacob, Lee Smith, Ai Koyanagi, Alexis Schnitzler, Jae Il Shin, Karel Kostev
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Osteoarthritis Parkinson’s disease Retrospective cohort study United Kingdom Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1e825226652e4b5c81d0f8f7abb87a77
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1e825226652e4b5c81d0f8f7abb87a77
record_format	dspace
spelling	oai:doaj.org-article:1e825226652e4b5c81d0f8f7abb87a772021-11-30T04:17:33ZAssociation between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom2590-112510.1016/j.prdoa.2021.100120https://doaj.org/article/1e825226652e4b5c81d0f8f7abb87a772021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590112521000323https://doaj.org/toc/2590-1125Background: Little is known on the potential relationship between osteoarthritis and Parkinson’s disease. Objective: Therefore, the objective of this retrospective cohort study was to analyze the association between osteoarthritis and the incidence of Parkinson’s disease in patients followed up for up to 10 years in general practices in the United Kingdom. Methods: This study included patients diagnosed for the first time with osteoarthritis in one of 256 general practices in the United Kingdom between 2000 and 2016 (index date). Patients without osteoarthritis were matched (1:1) to those with osteoarthritis using propensity scores based on sex, age and index year. In individuals without osteoarthritis, index date corresponded to a randomly selected visit date. The outcome of this study was the 10-year cumulative incidence of Parkinson’s disease in patients with and without osteoarthritis. Cox regression analyses were adjusted for common comorbidities. Results: This study included 260,224 patients (62.0% women; mean [SD] age 66.4 [12.7] years). The 10-year cumulative incidence of Parkinson’s disease was 1.2% in patients with osteoarthritis and 0.6% in their counterparts without osteoarthritis (log-rank p-value < 0.001). The adjusted Cox regression model further showed a positive and significant association between osteoarthritis and the incidence of Parkinson’s disease (HR = 1.82, 95% CI: 1.63–2.02). Similar results were obtained in all sex and age subgroups. Conclusions: In this retrospective cohort study conducted in the United Kingdom, there was a positive association between osteoarthritis and the incidence of Parkinson’s disease. More research is warranted to confirm or refute these findings in other settings and countries.Louis JacobLee SmithAi KoyanagiAlexis SchnitzlerJae Il ShinKarel KostevElsevierarticleOsteoarthritisParkinson’s diseaseRetrospective cohort studyUnited KingdomNeurology. Diseases of the nervous systemRC346-429ENClinical Parkinsonism & Related Disorders, Vol 5, Iss , Pp 100120- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Osteoarthritis Parkinson’s disease Retrospective cohort study United Kingdom Neurology. Diseases of the nervous system RC346-429
spellingShingle	Osteoarthritis Parkinson’s disease Retrospective cohort study United Kingdom Neurology. Diseases of the nervous system RC346-429 Louis Jacob Lee Smith Ai Koyanagi Alexis Schnitzler Jae Il Shin Karel Kostev Association between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom
description	Background: Little is known on the potential relationship between osteoarthritis and Parkinson’s disease. Objective: Therefore, the objective of this retrospective cohort study was to analyze the association between osteoarthritis and the incidence of Parkinson’s disease in patients followed up for up to 10 years in general practices in the United Kingdom. Methods: This study included patients diagnosed for the first time with osteoarthritis in one of 256 general practices in the United Kingdom between 2000 and 2016 (index date). Patients without osteoarthritis were matched (1:1) to those with osteoarthritis using propensity scores based on sex, age and index year. In individuals without osteoarthritis, index date corresponded to a randomly selected visit date. The outcome of this study was the 10-year cumulative incidence of Parkinson’s disease in patients with and without osteoarthritis. Cox regression analyses were adjusted for common comorbidities. Results: This study included 260,224 patients (62.0% women; mean [SD] age 66.4 [12.7] years). The 10-year cumulative incidence of Parkinson’s disease was 1.2% in patients with osteoarthritis and 0.6% in their counterparts without osteoarthritis (log-rank p-value < 0.001). The adjusted Cox regression model further showed a positive and significant association between osteoarthritis and the incidence of Parkinson’s disease (HR = 1.82, 95% CI: 1.63–2.02). Similar results were obtained in all sex and age subgroups. Conclusions: In this retrospective cohort study conducted in the United Kingdom, there was a positive association between osteoarthritis and the incidence of Parkinson’s disease. More research is warranted to confirm or refute these findings in other settings and countries.
format	article
author	Louis Jacob Lee Smith Ai Koyanagi Alexis Schnitzler Jae Il Shin Karel Kostev
author_facet	Louis Jacob Lee Smith Ai Koyanagi Alexis Schnitzler Jae Il Shin Karel Kostev
author_sort	Louis Jacob
title	Association between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom
title_short	Association between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom
title_full	Association between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom
title_fullStr	Association between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom
title_full_unstemmed	Association between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom
title_sort	association between osteoarthritis and the incidence of parkinson’s disease in the united kingdom
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1e825226652e4b5c81d0f8f7abb87a77
work_keys_str_mv	AT louisjacob associationbetweenosteoarthritisandtheincidenceofparkinsonsdiseaseintheunitedkingdom AT leesmith associationbetweenosteoarthritisandtheincidenceofparkinsonsdiseaseintheunitedkingdom AT aikoyanagi associationbetweenosteoarthritisandtheincidenceofparkinsonsdiseaseintheunitedkingdom AT alexisschnitzler associationbetweenosteoarthritisandtheincidenceofparkinsonsdiseaseintheunitedkingdom AT jaeilshin associationbetweenosteoarthritisandtheincidenceofparkinsonsdiseaseintheunitedkingdom AT karelkostev associationbetweenosteoarthritisandtheincidenceofparkinsonsdiseaseintheunitedkingdom
_version_	1718406730160799744

Association between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom

Ejemplares similares