Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review

Nadda Muhamad,1 Tullayakorn Plengsuriyakarn,1,2 Kesara Na-Bangchang1,2 1Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand; 2Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medic...

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Autores principales:	Muhamad N, Plengsuriyakarn T, Na-Bangchang K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Active targeting nanoparticles Chemotherapy Traditional medicine Herbal medicine Cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1e83c62f6eeb451d87b42a78928c80f4
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spelling	oai:doaj.org-article:1e83c62f6eeb451d87b42a78928c80f42021-12-02T09:31:41ZApplication of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review1178-2013https://doaj.org/article/1e83c62f6eeb451d87b42a78928c80f42018-07-01T00:00:00Zhttps://www.dovepress.com/application-of-active-targeting-nanoparticle-delivery-system-for-chemo-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nadda Muhamad,1 Tullayakorn Plengsuriyakarn,1,2 Kesara Na-Bangchang1,2 1Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand; 2Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand Abstract: Patients treated with conventional cancer chemotherapy suffer from side effects of the drugs due to non-selective action of chemotherapeutic drugs to normal cells. Active targeting nanoparticles that are conjugated to targeting ligands on the surface of nanoparticles play an important role in improving drug selectivity to the cancer cell. Several chemotherapeutic drugs and traditional/herbal medicines reported for anticancer activities have been investigated for their selective delivery to cancer cells by active targeting nanoparticles. This systematic review summarizes reports on this application. Literature search was conducted through PubMed database search up to March 2017 using the terms nanoparticle, chemotherapy, traditional medicine, herbal medicine, natural medicine, natural compound, cancer treatment, and active targeting. Out of 695 published articles, 61 articles were included in the analysis based on the predefined inclusion and exclusion criteria. The targeting ligands included proteins/peptides, hyaluronic acid, folic acid, antibodies/antibody fragments, aptamer, and carbohydrates/polysaccharides. In vitro and in vivo studies suggest that active targeting nanoparticles increase selectivity in cellular uptake and/or cytotoxicity over the conventional chemotherapeutic drugs and non-targeted nanoparticle platform, particularly enhancement of drug efficacy and safety. However, clinical studies are required to confirm these findings. Keywords: active targeting, nanoparticles, ligands, chemotherapy, natural active compounds, cancerMuhamad NPlengsuriyakarn TNa-Bangchang KDove Medical PressarticleActive targeting nanoparticlesChemotherapyTraditional medicineHerbal medicineCancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 3921-3935 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Active targeting nanoparticles Chemotherapy Traditional medicine Herbal medicine Cancer Medicine (General) R5-920
spellingShingle	Active targeting nanoparticles Chemotherapy Traditional medicine Herbal medicine Cancer Medicine (General) R5-920 Muhamad N Plengsuriyakarn T Na-Bangchang K Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review
description	Nadda Muhamad,1 Tullayakorn Plengsuriyakarn,1,2 Kesara Na-Bangchang1,2 1Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand; 2Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand Abstract: Patients treated with conventional cancer chemotherapy suffer from side effects of the drugs due to non-selective action of chemotherapeutic drugs to normal cells. Active targeting nanoparticles that are conjugated to targeting ligands on the surface of nanoparticles play an important role in improving drug selectivity to the cancer cell. Several chemotherapeutic drugs and traditional/herbal medicines reported for anticancer activities have been investigated for their selective delivery to cancer cells by active targeting nanoparticles. This systematic review summarizes reports on this application. Literature search was conducted through PubMed database search up to March 2017 using the terms nanoparticle, chemotherapy, traditional medicine, herbal medicine, natural medicine, natural compound, cancer treatment, and active targeting. Out of 695 published articles, 61 articles were included in the analysis based on the predefined inclusion and exclusion criteria. The targeting ligands included proteins/peptides, hyaluronic acid, folic acid, antibodies/antibody fragments, aptamer, and carbohydrates/polysaccharides. In vitro and in vivo studies suggest that active targeting nanoparticles increase selectivity in cellular uptake and/or cytotoxicity over the conventional chemotherapeutic drugs and non-targeted nanoparticle platform, particularly enhancement of drug efficacy and safety. However, clinical studies are required to confirm these findings. Keywords: active targeting, nanoparticles, ligands, chemotherapy, natural active compounds, cancer
format	article
author	Muhamad N Plengsuriyakarn T Na-Bangchang K
author_facet	Muhamad N Plengsuriyakarn T Na-Bangchang K
author_sort	Muhamad N
title	Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review
title_short	Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review
title_full	Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review
title_fullStr	Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review
title_full_unstemmed	Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review
title_sort	application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1e83c62f6eeb451d87b42a78928c80f4
work_keys_str_mv	AT muhamadn applicationofactivetargetingnanoparticledeliverysystemforchemotherapeuticdrugsandtraditionalherbalmedicinesincancertherapyasystematicreview AT plengsuriyakarnt applicationofactivetargetingnanoparticledeliverysystemforchemotherapeuticdrugsandtraditionalherbalmedicinesincancertherapyasystematicreview AT nabangchangk applicationofactivetargetingnanoparticledeliverysystemforchemotherapeuticdrugsandtraditionalherbalmedicinesincancertherapyasystematicreview
_version_	1718398053319180288

Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review

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