Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.

The ability of persistent organic pollutants (POPs) with endocrine disrupting properties to interfere with the developing reproductive system is of increasing concern. POPs are transferred from dams to offspring and the high sensitivity of neonates to endocrine disturbances may be caused by underdev...

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Autores principales:	Silje Modahl Johanson, Erik Ropstad, Gunn Charlotte Østby, Mona Aleksandersen, Galia Zamaratskaia, Gudrun Seeberg Boge, Ruth Halsne, Cathrine Trangerud, Jan Ludvig Lyche, Hanne Friis Berntsen, Karin Elisabeth Zimmer, Steven Verhaegen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1e8623ac2ff045869a02a3b0c5b6eef7
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spelling	oai:doaj.org-article:1e8623ac2ff045869a02a3b0c5b6eef72021-12-02T20:10:49ZPerinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.1932-620310.1371/journal.pone.0252954https://doaj.org/article/1e8623ac2ff045869a02a3b0c5b6eef72021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252954https://doaj.org/toc/1932-6203The ability of persistent organic pollutants (POPs) with endocrine disrupting properties to interfere with the developing reproductive system is of increasing concern. POPs are transferred from dams to offspring and the high sensitivity of neonates to endocrine disturbances may be caused by underdeveloped systems of metabolism and excretion. The present study aimed to characterize the effect of in utero and lactational exposure to a human relevant mixture of POPs on the female mammary gland, ovarian folliculogenesis and liver function in CD-1 offspring mice. Dams were exposed to the mixture through the diet at Control, Low or High doses (representing 0x, 5000x and 100 000x human estimated daily intake levels, respectively) from weaning and throughout mating, gestation, and lactation. Perinatally exposed female offspring exhibited altered mammary gland development and a suppressed ovarian follicle maturation. Increased hepatic cytochrome P450 enzymatic activities indirectly indicated activation of nuclear receptors and potential generation of reactive products. Hepatocellular hypertrophy was observed from weaning until 30 weeks of age and could potentially lead to hepatotoxicity. Further studies should investigate the effects of human relevant mixtures of POPs on several hormones combined with female reproductive ability and liver function.Silje Modahl JohansonErik RopstadGunn Charlotte ØstbyMona AleksandersenGalia ZamaratskaiaGudrun Seeberg BogeRuth HalsneCathrine TrangerudJan Ludvig LycheHanne Friis BerntsenKarin Elisabeth ZimmerSteven VerhaegenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252954 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Silje Modahl Johanson Erik Ropstad Gunn Charlotte Østby Mona Aleksandersen Galia Zamaratskaia Gudrun Seeberg Boge Ruth Halsne Cathrine Trangerud Jan Ludvig Lyche Hanne Friis Berntsen Karin Elisabeth Zimmer Steven Verhaegen Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.
description	The ability of persistent organic pollutants (POPs) with endocrine disrupting properties to interfere with the developing reproductive system is of increasing concern. POPs are transferred from dams to offspring and the high sensitivity of neonates to endocrine disturbances may be caused by underdeveloped systems of metabolism and excretion. The present study aimed to characterize the effect of in utero and lactational exposure to a human relevant mixture of POPs on the female mammary gland, ovarian folliculogenesis and liver function in CD-1 offspring mice. Dams were exposed to the mixture through the diet at Control, Low or High doses (representing 0x, 5000x and 100 000x human estimated daily intake levels, respectively) from weaning and throughout mating, gestation, and lactation. Perinatally exposed female offspring exhibited altered mammary gland development and a suppressed ovarian follicle maturation. Increased hepatic cytochrome P450 enzymatic activities indirectly indicated activation of nuclear receptors and potential generation of reactive products. Hepatocellular hypertrophy was observed from weaning until 30 weeks of age and could potentially lead to hepatotoxicity. Further studies should investigate the effects of human relevant mixtures of POPs on several hormones combined with female reproductive ability and liver function.
format	article
author	Silje Modahl Johanson Erik Ropstad Gunn Charlotte Østby Mona Aleksandersen Galia Zamaratskaia Gudrun Seeberg Boge Ruth Halsne Cathrine Trangerud Jan Ludvig Lyche Hanne Friis Berntsen Karin Elisabeth Zimmer Steven Verhaegen
author_facet	Silje Modahl Johanson Erik Ropstad Gunn Charlotte Østby Mona Aleksandersen Galia Zamaratskaia Gudrun Seeberg Boge Ruth Halsne Cathrine Trangerud Jan Ludvig Lyche Hanne Friis Berntsen Karin Elisabeth Zimmer Steven Verhaegen
author_sort	Silje Modahl Johanson
title	Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.
title_short	Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.
title_full	Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.
title_fullStr	Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.
title_full_unstemmed	Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.
title_sort	perinatal exposure to a human relevant mixture of persistent organic pollutants: effects on mammary gland development, ovarian folliculogenesis and liver in cd-1 mice.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1e8623ac2ff045869a02a3b0c5b6eef7
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Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice.

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