Antipsychotic treatments for the elderly: efficacy and safety of aripiprazole

Izchak Kohen1, Paula E Lester2, Sum Lam31Division of Geriatric Psychiatry, Zucker-Hillside Hospital, Glen Oaks, NY, USA; 2Division of Geriatric Medicine, Winthrop University Hospital, Mineola, NY, USA; 3Division of Pharmacy and Geriatrics, St. John&rsquo;s University College of Pharmacy and...

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Autores principales:	Izchak Kohen, Paula E Lester, Sum Lam
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1e895516365f4bd180c20bd790210b76
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spelling	oai:doaj.org-article:1e895516365f4bd180c20bd790210b762021-12-02T07:57:30ZAntipsychotic treatments for the elderly: efficacy and safety of aripiprazole1176-63281178-2021https://doaj.org/article/1e895516365f4bd180c20bd790210b762010-03-01T00:00:00Zhttp://www.dovepress.com/antipsychotic-treatments-for-the-elderly-efficacy-and-safety-of-aripip-a4023https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Izchak Kohen1, Paula E Lester2, Sum Lam31Division of Geriatric Psychiatry, Zucker-Hillside Hospital, Glen Oaks, NY, USA; 2Division of Geriatric Medicine, Winthrop University Hospital, Mineola, NY, USA; 3Division of Pharmacy and Geriatrics, St. John&rsquo;s University College of Pharmacy and Allied Health Professions, Queens, NY, USAAbstract: Delusions, hallucinations and other psychotic symptoms can accompany a number of conditions in late life. As such, elderly patients are commonly prescribed antipsychotic medications for the treatment of psychosis in both acute and chronic conditions. Those conditions include schizophrenia, bipolar disorder, depression and dementia. Elderly patients are at an increased risk of adverse events from antipsychotic medications because of age-related pharmacodynamic and pharmacokinetic changes as well as polypharmacy. Drug selection should be individualized to the patient&rsquo;s previous history of antipsychotic use, current medical conditions, potential drug interactions, and potential side effects of the antipsychotic. Specifically, metabolic side effects should be closely monitored in this population. This paper provides a review of aripiprazole, a newer second generation antipsychotic agent, for its use in a variety of psychiatric disorders in the elderly including schizophrenia, bipolar disorder, dementia, Parkinson&rsquo;s disease and depression. We will review the pharmacokinetics and pharmacodynamics of aripiprazole as well as dosing, diagnostic indications, efficacy studies, and tolerability including its metabolic profile. We will also detail patient focused perspectives including quality of life, patient satisfaction and adherence.Keywords: aripiprazole, antipsychotics, elderly, adverse drug reaction Izchak KohenPaula E LesterSum LamDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 47-58 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Izchak Kohen Paula E Lester Sum Lam Antipsychotic treatments for the elderly: efficacy and safety of aripiprazole
description	Izchak Kohen1, Paula E Lester2, Sum Lam31Division of Geriatric Psychiatry, Zucker-Hillside Hospital, Glen Oaks, NY, USA; 2Division of Geriatric Medicine, Winthrop University Hospital, Mineola, NY, USA; 3Division of Pharmacy and Geriatrics, St. John&rsquo;s University College of Pharmacy and Allied Health Professions, Queens, NY, USAAbstract: Delusions, hallucinations and other psychotic symptoms can accompany a number of conditions in late life. As such, elderly patients are commonly prescribed antipsychotic medications for the treatment of psychosis in both acute and chronic conditions. Those conditions include schizophrenia, bipolar disorder, depression and dementia. Elderly patients are at an increased risk of adverse events from antipsychotic medications because of age-related pharmacodynamic and pharmacokinetic changes as well as polypharmacy. Drug selection should be individualized to the patient&rsquo;s previous history of antipsychotic use, current medical conditions, potential drug interactions, and potential side effects of the antipsychotic. Specifically, metabolic side effects should be closely monitored in this population. This paper provides a review of aripiprazole, a newer second generation antipsychotic agent, for its use in a variety of psychiatric disorders in the elderly including schizophrenia, bipolar disorder, dementia, Parkinson&rsquo;s disease and depression. We will review the pharmacokinetics and pharmacodynamics of aripiprazole as well as dosing, diagnostic indications, efficacy studies, and tolerability including its metabolic profile. We will also detail patient focused perspectives including quality of life, patient satisfaction and adherence.Keywords: aripiprazole, antipsychotics, elderly, adverse drug reaction
format	article
author	Izchak Kohen Paula E Lester Sum Lam
author_facet	Izchak Kohen Paula E Lester Sum Lam
author_sort	Izchak Kohen
title	Antipsychotic treatments for the elderly: efficacy and safety of aripiprazole
title_short	Antipsychotic treatments for the elderly: efficacy and safety of aripiprazole
title_full	Antipsychotic treatments for the elderly: efficacy and safety of aripiprazole
title_fullStr	Antipsychotic treatments for the elderly: efficacy and safety of aripiprazole
title_full_unstemmed	Antipsychotic treatments for the elderly: efficacy and safety of aripiprazole
title_sort	antipsychotic treatments for the elderly: efficacy and safety of aripiprazole
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/1e895516365f4bd180c20bd790210b76
work_keys_str_mv	AT izchakkohen antipsychotictreatmentsfortheelderlyefficacyandsafetyofaripiprazole AT paulaelester antipsychotictreatmentsfortheelderlyefficacyandsafetyofaripiprazole AT sumlam antipsychotictreatmentsfortheelderlyefficacyandsafetyofaripiprazole
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Antipsychotic treatments for the elderly: efficacy and safety of aripiprazole

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