Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent signalling activation and tumour progression.

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Autores principales:	HaoRan Tang, Leo Leung, Grazia Saturno, Amaya Viros, Duncan Smith, Gianpiero Di Leva, Eamonn Morrison, Dan Niculescu-Duvaz, Filipa Lopes, Louise Johnson, Nathalie Dhomen, Caroline Springer, Richard Marais
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e8df04e596541cea30f865991c28ab1
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spelling	oai:doaj.org-article:1e8df04e596541cea30f865991c28ab12021-12-02T17:06:25ZLysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface10.1038/ncomms149092041-1723https://doaj.org/article/1e8df04e596541cea30f865991c28ab12017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14909https://doaj.org/toc/2041-1723Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent signalling activation and tumour progression.HaoRan TangLeo LeungGrazia SaturnoAmaya VirosDuncan SmithGianpiero Di LevaEamonn MorrisonDan Niculescu-DuvazFilipa LopesLouise JohnsonNathalie DhomenCaroline SpringerRichard MaraisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q HaoRan Tang Leo Leung Grazia Saturno Amaya Viros Duncan Smith Gianpiero Di Leva Eamonn Morrison Dan Niculescu-Duvaz Filipa Lopes Louise Johnson Nathalie Dhomen Caroline Springer Richard Marais Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
description	Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent signalling activation and tumour progression.
format	article
author	HaoRan Tang Leo Leung Grazia Saturno Amaya Viros Duncan Smith Gianpiero Di Leva Eamonn Morrison Dan Niculescu-Duvaz Filipa Lopes Louise Johnson Nathalie Dhomen Caroline Springer Richard Marais
author_facet	HaoRan Tang Leo Leung Grazia Saturno Amaya Viros Duncan Smith Gianpiero Di Leva Eamonn Morrison Dan Niculescu-Duvaz Filipa Lopes Louise Johnson Nathalie Dhomen Caroline Springer Richard Marais
author_sort	HaoRan Tang
title	Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
title_short	Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
title_full	Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
title_fullStr	Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
title_full_unstemmed	Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
title_sort	lysyl oxidase drives tumour progression by trapping egf receptors at the cell surface
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1e8df04e596541cea30f865991c28ab1
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Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

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