The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study
Vladimir Grošić,1 Petra Folnegovic Grošić,2 Petra Kalember,3,4 Maja Bajs Janović,2 Marko Radoš,3,4 Mate Mihanović,1 Neven Henigsberg3,51Psychiatric Hospital Sveti Ivan, Zagreb, 2University Hospital Center Zagreb, University of Zagreb, Zagreb, 3Polyclinic Neuron, Cro...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1e9212947ea445d7855b9a8c311f956b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:1e9212947ea445d7855b9a8c311f956b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:1e9212947ea445d7855b9a8c311f956b2021-12-02T00:34:14ZThe effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study1178-2021https://doaj.org/article/1e9212947ea445d7855b9a8c311f956b2014-07-01T00:00:00Zhttp://www.dovepress.com/the-effect-of-atypical-antipsychotics-on-brain-n-acetylaspartate-level-a17504https://doaj.org/toc/1178-2021 Vladimir Grošić,1 Petra Folnegovic Grošić,2 Petra Kalember,3,4 Maja Bajs Janović,2 Marko Radoš,3,4 Mate Mihanović,1 Neven Henigsberg3,51Psychiatric Hospital Sveti Ivan, Zagreb, 2University Hospital Center Zagreb, University of Zagreb, Zagreb, 3Polyclinic Neuron, Croatian Institute for Brain Research, Zagreb, 4Department of Neuropharmacology and Behavioral Pharmacology, Croatian Institute for Brain Research, University of Zagreb, Zagreb, 5Vrapče University Hospital, University of Zagreb, Zagreb, CroatiaPurpose: To investigate the correlates of a clinical therapeutic response by using the parameters measured by proton magnetic resonance spectroscopy after the administration of atypical antipsychotics.Patients and methods: Twenty-five antipsychotic-naïve first-episode patients with schizophrenia were monitored for 12 months. The patients were evaluated using 1H magnetic resonance spectroscopy in the dorsolateral prefrontal cortex and Positive and Negative Syndrome Scale, Clinical Global Impression Scale of Severity, Tower of London – Drexel University, Letter–Number Span Test, Trail Making Test A, and Personal and Social Performance Scale. They were administered atypical antipsychotics, starting with quetiapine. In the absence of a therapeutic response, another antipsychotic was introduced.Results: After 12 study months, the N-acetylaspartate/creatine (NAA/Cr) level did not significantly change at the whole-group level. Additional analysis revealed a significant rise in the NAA/Cr level in the study group that stayed on the same antipsychotic throughout the study course (P=0.008) and a significant drop in NAA/Cr in the study group that switched antipsychotics (P=0.005). On the whole-group level, no significant correlations between NAA/Cr values and other scores were found at either baseline or after 12 study months.Conclusion: One-year treatment with atypical antipsychotics administered to antipsychotic-naïve patients didn’t result in a significant rise in the NAA/Cr ratio. However, a significant rise was witnessed in the study group in which a satisfactory therapeutic response had been achieved with a single antipsychotic administration.Keywords: schizophrenia, atypical antipsychotics, NAA, MRSGrošić VFolnegović Grošić PKalember PBajs Janović MRadoš MMihanović MHenigsberg NDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1243-1253 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Grošić V Folnegović Grošić P Kalember P Bajs Janović M Radoš M Mihanović M Henigsberg N The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study |
| description |
Vladimir Grošić,1 Petra Folnegovic Grošić,2 Petra Kalember,3,4 Maja Bajs Janović,2 Marko Radoš,3,4 Mate Mihanović,1 Neven Henigsberg3,51Psychiatric Hospital Sveti Ivan, Zagreb, 2University Hospital Center Zagreb, University of Zagreb, Zagreb, 3Polyclinic Neuron, Croatian Institute for Brain Research, Zagreb, 4Department of Neuropharmacology and Behavioral Pharmacology, Croatian Institute for Brain Research, University of Zagreb, Zagreb, 5Vrapče University Hospital, University of Zagreb, Zagreb, CroatiaPurpose: To investigate the correlates of a clinical therapeutic response by using the parameters measured by proton magnetic resonance spectroscopy after the administration of atypical antipsychotics.Patients and methods: Twenty-five antipsychotic-naïve first-episode patients with schizophrenia were monitored for 12 months. The patients were evaluated using 1H magnetic resonance spectroscopy in the dorsolateral prefrontal cortex and Positive and Negative Syndrome Scale, Clinical Global Impression Scale of Severity, Tower of London – Drexel University, Letter–Number Span Test, Trail Making Test A, and Personal and Social Performance Scale. They were administered atypical antipsychotics, starting with quetiapine. In the absence of a therapeutic response, another antipsychotic was introduced.Results: After 12 study months, the N-acetylaspartate/creatine (NAA/Cr) level did not significantly change at the whole-group level. Additional analysis revealed a significant rise in the NAA/Cr level in the study group that stayed on the same antipsychotic throughout the study course (P=0.008) and a significant drop in NAA/Cr in the study group that switched antipsychotics (P=0.005). On the whole-group level, no significant correlations between NAA/Cr values and other scores were found at either baseline or after 12 study months.Conclusion: One-year treatment with atypical antipsychotics administered to antipsychotic-naïve patients didn’t result in a significant rise in the NAA/Cr ratio. However, a significant rise was witnessed in the study group in which a satisfactory therapeutic response had been achieved with a single antipsychotic administration.Keywords: schizophrenia, atypical antipsychotics, NAA, MRS |
| format |
article |
| author |
Grošić V Folnegović Grošić P Kalember P Bajs Janović M Radoš M Mihanović M Henigsberg N |
| author_facet |
Grošić V Folnegović Grošić P Kalember P Bajs Janović M Radoš M Mihanović M Henigsberg N |
| author_sort |
Grošić V |
| title |
The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study |
| title_short |
The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study |
| title_full |
The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study |
| title_fullStr |
The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study |
| title_full_unstemmed |
The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study |
| title_sort |
effect of atypical antipsychotics on brain n-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/1e9212947ea445d7855b9a8c311f956b |
| work_keys_str_mv |
AT groscaronicv theeffectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT folnegovicgroscaronicp theeffectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT kalemberp theeffectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT bajsjanovicm theeffectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT radoscaronm theeffectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT mihanovicm theeffectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT henigsbergn theeffectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT groscaronicv effectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT folnegovicgroscaronicp effectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT kalemberp effectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT bajsjanovicm effectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT radoscaronm effectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT mihanovicm effectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy AT henigsbergn effectofatypicalantipsychoticsonbrainnacetylaspartatelevelsinantipsychoticnaiumlvefirstepisodepatientswithschizophreniaapreliminarystudy |
| _version_ |
1718403602103402496 |