Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate

Melanoma originates from the malignant transformation of melanocytes and is one of the most aggressive forms of cancer. The recent approval of several drugs has increased the chance of survival although a significant subset of patients with metastatic melanoma do not show a long-lasting response to...

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Autores principales: Elisabetta Catalani, Matteo Giovarelli, Silvia Zecchini, Cristiana Perrotta, Davide Cervia
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Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/1e9733487e2d4d84802337f4724e1aed
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spelling oai:doaj.org-article:1e9733487e2d4d84802337f4724e1aed2021-11-25T17:04:02ZOxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate10.3390/cancers132257912072-6694https://doaj.org/article/1e9733487e2d4d84802337f4724e1aed2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5791https://doaj.org/toc/2072-6694Melanoma originates from the malignant transformation of melanocytes and is one of the most aggressive forms of cancer. The recent approval of several drugs has increased the chance of survival although a significant subset of patients with metastatic melanoma do not show a long-lasting response to these treatments. The complex cross-talk between oxidative stress and the catabolic process autophagy seems to play a central role in all aspects of melanoma pathophysiology, from initiation to progression and metastasis, including drug resistance. However, determining the fine role of autophagy in cancer death and in response to redox disruption is still a fundamental challenge in order to advance both basic and translational aspects of this field. In order to summarize the interactions among reactive oxygen and nitrogen species, autophagy machinery and proliferation/growth/death/apoptosis/survival, we provide here a narrative review of the preclinical evidence for drugs/treatments that modulate oxidative stress and autophagy in melanoma cells. The significance and the potential for pharmacological targeting (also through multiple and combination approaches) of these two different events, which can contribute independently or simultaneously to the fate of melanoma, may help to define new processes and their interconnections underlying skin cancer biology and unravel new reliable approaches.Elisabetta CatalaniMatteo GiovarelliSilvia ZecchiniCristiana PerrottaDavide CerviaMDPI AGarticlereactive oxygen and nitrogen speciesautophagosomescell death and survivalanti and pro-oxidantsautophagy modulatorsskin cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5791, p 5791 (2021)
institution DOAJ
collection DOAJ
language EN
topic reactive oxygen and nitrogen species
autophagosomes
cell death and survival
anti and pro-oxidants
autophagy modulators
skin cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle reactive oxygen and nitrogen species
autophagosomes
cell death and survival
anti and pro-oxidants
autophagy modulators
skin cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Elisabetta Catalani
Matteo Giovarelli
Silvia Zecchini
Cristiana Perrotta
Davide Cervia
Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate
description Melanoma originates from the malignant transformation of melanocytes and is one of the most aggressive forms of cancer. The recent approval of several drugs has increased the chance of survival although a significant subset of patients with metastatic melanoma do not show a long-lasting response to these treatments. The complex cross-talk between oxidative stress and the catabolic process autophagy seems to play a central role in all aspects of melanoma pathophysiology, from initiation to progression and metastasis, including drug resistance. However, determining the fine role of autophagy in cancer death and in response to redox disruption is still a fundamental challenge in order to advance both basic and translational aspects of this field. In order to summarize the interactions among reactive oxygen and nitrogen species, autophagy machinery and proliferation/growth/death/apoptosis/survival, we provide here a narrative review of the preclinical evidence for drugs/treatments that modulate oxidative stress and autophagy in melanoma cells. The significance and the potential for pharmacological targeting (also through multiple and combination approaches) of these two different events, which can contribute independently or simultaneously to the fate of melanoma, may help to define new processes and their interconnections underlying skin cancer biology and unravel new reliable approaches.
format article
author Elisabetta Catalani
Matteo Giovarelli
Silvia Zecchini
Cristiana Perrotta
Davide Cervia
author_facet Elisabetta Catalani
Matteo Giovarelli
Silvia Zecchini
Cristiana Perrotta
Davide Cervia
author_sort Elisabetta Catalani
title Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate
title_short Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate
title_full Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate
title_fullStr Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate
title_full_unstemmed Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate
title_sort oxidative stress and autophagy as key targets in melanoma cell fate
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/1e9733487e2d4d84802337f4724e1aed
work_keys_str_mv AT elisabettacatalani oxidativestressandautophagyaskeytargetsinmelanomacellfate
AT matteogiovarelli oxidativestressandautophagyaskeytargetsinmelanomacellfate
AT silviazecchini oxidativestressandautophagyaskeytargetsinmelanomacellfate
AT cristianaperrotta oxidativestressandautophagyaskeytargetsinmelanomacellfate
AT davidecervia oxidativestressandautophagyaskeytargetsinmelanomacellfate
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