Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

To understand how hCEACAM1 transitions between monomeric and dimeric states that are required for its activity, Gandhi et al. investigate hCEACAM1 homodimeric, monomeric, and transition states and their behavior in solution. This study suggests the flexibility of the GFCC’ face and its role in gover...

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Auteurs principaux:	Amit K. Gandhi, Zhen-Yu J. Sun, Walter M. Kim, Yu-Hwa Huang, Yasuyuki Kondo, Daniel A. Bonsor, Eric J. Sundberg, Gerhard Wagner, Vijay K. Kuchroo, Gregory A. Petsko, Richard S. Blumberg
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/1e98a0721d5041b7bcee1fce74ebca91
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spelling	oai:doaj.org-article:1e98a0721d5041b7bcee1fce74ebca912021-12-02T17:05:09ZStructural basis of the dynamic human CEACAM1 monomer-dimer equilibrium10.1038/s42003-021-01871-22399-3642https://doaj.org/article/1e98a0721d5041b7bcee1fce74ebca912021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01871-2https://doaj.org/toc/2399-3642To understand how hCEACAM1 transitions between monomeric and dimeric states that are required for its activity, Gandhi et al. investigate hCEACAM1 homodimeric, monomeric, and transition states and their behavior in solution. This study suggests the flexibility of the GFCC’ face and its role in governing the formation of hCEACAM1 dimers and selective heterodimers.Amit K. GandhiZhen-Yu J. SunWalter M. KimYu-Hwa HuangYasuyuki KondoDaniel A. BonsorEric J. SundbergGerhard WagnerVijay K. KuchrooGregory A. PetskoRichard S. BlumbergNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Amit K. Gandhi Zhen-Yu J. Sun Walter M. Kim Yu-Hwa Huang Yasuyuki Kondo Daniel A. Bonsor Eric J. Sundberg Gerhard Wagner Vijay K. Kuchroo Gregory A. Petsko Richard S. Blumberg Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
description	To understand how hCEACAM1 transitions between monomeric and dimeric states that are required for its activity, Gandhi et al. investigate hCEACAM1 homodimeric, monomeric, and transition states and their behavior in solution. This study suggests the flexibility of the GFCC’ face and its role in governing the formation of hCEACAM1 dimers and selective heterodimers.
format	article
author	Amit K. Gandhi Zhen-Yu J. Sun Walter M. Kim Yu-Hwa Huang Yasuyuki Kondo Daniel A. Bonsor Eric J. Sundberg Gerhard Wagner Vijay K. Kuchroo Gregory A. Petsko Richard S. Blumberg
author_facet	Amit K. Gandhi Zhen-Yu J. Sun Walter M. Kim Yu-Hwa Huang Yasuyuki Kondo Daniel A. Bonsor Eric J. Sundberg Gerhard Wagner Vijay K. Kuchroo Gregory A. Petsko Richard S. Blumberg
author_sort	Amit K. Gandhi
title	Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
title_short	Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
title_full	Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
title_fullStr	Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
title_full_unstemmed	Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
title_sort	structural basis of the dynamic human ceacam1 monomer-dimer equilibrium
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1e98a0721d5041b7bcee1fce74ebca91
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Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

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