FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons...

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Autores principales:	Lorenzo Errichelli, Stefano Dini Modigliani, Pietro Laneve, Alessio Colantoni, Ivano Legnini, Davide Capauto, Alessandro Rosa, Riccardo De Santis, Rebecca Scarfò, Giovanna Peruzzi, Lei Lu, Elisa Caffarelli, Neil A. Shneider, Mariangela Morlando, Irene Bozzoni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1e9c2716f18a4d80882bcb92f54bc792
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spelling	oai:doaj.org-article:1e9c2716f18a4d80882bcb92f54bc7922021-12-02T15:39:04ZFUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons10.1038/ncomms147412041-1723https://doaj.org/article/1e9c2716f18a4d80882bcb92f54bc7922017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14741https://doaj.org/toc/2041-1723The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons and that ALS-associated FUS mutations affect the biogenesis of circRNAs.Lorenzo ErrichelliStefano Dini ModiglianiPietro LaneveAlessio ColantoniIvano LegniniDavide CapautoAlessandro RosaRiccardo De SantisRebecca ScarfòGiovanna PeruzziLei LuElisa CaffarelliNeil A. ShneiderMariangela MorlandoIrene BozzoniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lorenzo Errichelli Stefano Dini Modigliani Pietro Laneve Alessio Colantoni Ivano Legnini Davide Capauto Alessandro Rosa Riccardo De Santis Rebecca Scarfò Giovanna Peruzzi Lei Lu Elisa Caffarelli Neil A. Shneider Mariangela Morlando Irene Bozzoni FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
description	The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circRNA) production in stem cell-derived motor neurons and that ALS-associated FUS mutations affect the biogenesis of circRNAs.
format	article
author	Lorenzo Errichelli Stefano Dini Modigliani Pietro Laneve Alessio Colantoni Ivano Legnini Davide Capauto Alessandro Rosa Riccardo De Santis Rebecca Scarfò Giovanna Peruzzi Lei Lu Elisa Caffarelli Neil A. Shneider Mariangela Morlando Irene Bozzoni
author_facet	Lorenzo Errichelli Stefano Dini Modigliani Pietro Laneve Alessio Colantoni Ivano Legnini Davide Capauto Alessandro Rosa Riccardo De Santis Rebecca Scarfò Giovanna Peruzzi Lei Lu Elisa Caffarelli Neil A. Shneider Mariangela Morlando Irene Bozzoni
author_sort	Lorenzo Errichelli
title	FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
title_short	FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
title_full	FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
title_fullStr	FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
title_full_unstemmed	FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
title_sort	fus affects circular rna expression in murine embryonic stem cell-derived motor neurons
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1e9c2716f18a4d80882bcb92f54bc792
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FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

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