Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
Mechanistic inference following GWAS is hampered by the lack of tissue-specific transcriptomic resources. Here the authors combine genetic variants predisposing to type 2 diabetes with human pancreatic islet RNA-seq data. They identify 7741 islet expression quantitative trait loci (eQTLs), providing...
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2020
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oai:doaj.org-article:1e9cd2a221bf4b5fa3193842e74efdfa2021-12-02T17:37:42ZGenetic variant effects on gene expression in human pancreatic islets and their implications for T2D10.1038/s41467-020-18581-82041-1723https://doaj.org/article/1e9cd2a221bf4b5fa3193842e74efdfa2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18581-8https://doaj.org/toc/2041-1723Mechanistic inference following GWAS is hampered by the lack of tissue-specific transcriptomic resources. Here the authors combine genetic variants predisposing to type 2 diabetes with human pancreatic islet RNA-seq data. They identify 7741 islet expression quantitative trait loci (eQTLs), providing a resource for functional interpretation of association signals mapping to non-coding sequence.Ana ViñuelaArushi VarshneyMartijn van de BuntRashmi B. PrasadOlof AsplundAmanda BennettMichael BoehnkeAndrew A. BrownMichael R. ErdosJoão FadistaOla HanssonGad HatemCédric HowaldApoorva K. IyengarPaul JohnsonUlrika KrusPatrick E. MacDonaldAnubha MahajanJocelyn E. Manning FoxNarisu NarisuVibe NylanderPeter OrchardNikolay OskolkovNikolaos I. PanousisAnthony PayneMichael L. StitzelSwarooparani VadlamudiRyan WelchFrancis S. CollinsKaren L. MohlkeAnna L. GloynLaura J. ScottEmmanouil T. DermitzakisLeif GroopStephen C. J. ParkerMark I. McCarthyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q Ana Viñuela Arushi Varshney Martijn van de Bunt Rashmi B. Prasad Olof Asplund Amanda Bennett Michael Boehnke Andrew A. Brown Michael R. Erdos João Fadista Ola Hansson Gad Hatem Cédric Howald Apoorva K. Iyengar Paul Johnson Ulrika Krus Patrick E. MacDonald Anubha Mahajan Jocelyn E. Manning Fox Narisu Narisu Vibe Nylander Peter Orchard Nikolay Oskolkov Nikolaos I. Panousis Anthony Payne Michael L. Stitzel Swarooparani Vadlamudi Ryan Welch Francis S. Collins Karen L. Mohlke Anna L. Gloyn Laura J. Scott Emmanouil T. Dermitzakis Leif Groop Stephen C. J. Parker Mark I. McCarthy Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D |
| description |
Mechanistic inference following GWAS is hampered by the lack of tissue-specific transcriptomic resources. Here the authors combine genetic variants predisposing to type 2 diabetes with human pancreatic islet RNA-seq data. They identify 7741 islet expression quantitative trait loci (eQTLs), providing a resource for functional interpretation of association signals mapping to non-coding sequence. |
| format |
article |
| author |
Ana Viñuela Arushi Varshney Martijn van de Bunt Rashmi B. Prasad Olof Asplund Amanda Bennett Michael Boehnke Andrew A. Brown Michael R. Erdos João Fadista Ola Hansson Gad Hatem Cédric Howald Apoorva K. Iyengar Paul Johnson Ulrika Krus Patrick E. MacDonald Anubha Mahajan Jocelyn E. Manning Fox Narisu Narisu Vibe Nylander Peter Orchard Nikolay Oskolkov Nikolaos I. Panousis Anthony Payne Michael L. Stitzel Swarooparani Vadlamudi Ryan Welch Francis S. Collins Karen L. Mohlke Anna L. Gloyn Laura J. Scott Emmanouil T. Dermitzakis Leif Groop Stephen C. J. Parker Mark I. McCarthy |
| author_facet |
Ana Viñuela Arushi Varshney Martijn van de Bunt Rashmi B. Prasad Olof Asplund Amanda Bennett Michael Boehnke Andrew A. Brown Michael R. Erdos João Fadista Ola Hansson Gad Hatem Cédric Howald Apoorva K. Iyengar Paul Johnson Ulrika Krus Patrick E. MacDonald Anubha Mahajan Jocelyn E. Manning Fox Narisu Narisu Vibe Nylander Peter Orchard Nikolay Oskolkov Nikolaos I. Panousis Anthony Payne Michael L. Stitzel Swarooparani Vadlamudi Ryan Welch Francis S. Collins Karen L. Mohlke Anna L. Gloyn Laura J. Scott Emmanouil T. Dermitzakis Leif Groop Stephen C. J. Parker Mark I. McCarthy |
| author_sort |
Ana Viñuela |
| title |
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D |
| title_short |
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D |
| title_full |
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D |
| title_fullStr |
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D |
| title_full_unstemmed |
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D |
| title_sort |
genetic variant effects on gene expression in human pancreatic islets and their implications for t2d |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/1e9cd2a221bf4b5fa3193842e74efdfa |
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