Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition

Katja Linda Waller,1,2 Erik Lykke Mortensen,2,3 Kirsten Avlund,2,3,&dagger;, Merete Osler,3,4 Birgitte Fagerlund,5 Martin Lauritzen,2,6 Steen Gammeltoft,7 Poul Jennum1,2 1Danish Center for Sleep Medicine, Clinic of Clinical Neurophysiology, Rigshospitalet, University of Copenhagen, Copenhagen, D...

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Autores principales:	Waller KL, Mortensen EL, Avlund K, Osler M, Fagerlund B, Lauritzen M, Gammeltoft S, Jennum P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Circadian rhythm melatonin cortisol cognitive decline. Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/1e9d585a291b46f5b1af36dc4fc28b45
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spelling	oai:doaj.org-article:1e9d585a291b46f5b1af36dc4fc28b452021-12-02T01:10:09ZMelatonin and cortisol profiles in late midlife and their association with age-related changes in cognition1179-1608https://doaj.org/article/1e9d585a291b46f5b1af36dc4fc28b452016-01-01T00:00:00Zhttps://www.dovepress.com/melatonin-and-cortisol-profiles-in-late-midlife-and-their-association--peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Katja Linda Waller,1,2 Erik Lykke Mortensen,2,3 Kirsten Avlund,2,3,&dagger;, Merete Osler,3,4 Birgitte Fagerlund,5 Martin Lauritzen,2,6 Steen Gammeltoft,7 Poul Jennum1,2 1Danish Center for Sleep Medicine, Clinic of Clinical Neurophysiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; 2Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; 3Department of Public Health, University of Copenhagen, Copenhagen, Denmark; 4Research Center for Prevention and Health, Rigshospitalet, Glostrup, Denmark; 5Center for Neuropsychiatric Schizophrenia Research (CNSR), Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Glostrup, Denmark; 6Department of Clinical Neurophysiology, Rigshospitalet, Glostrup, Denmark; 7Department of Clinical Biochemistry, Rigshospitalet, Glostrup, Denmark &dagger;Kirsten Avlund passed away on June 15, 2012 Abstract: Previous studies have reported an association between circadian disturbances and age-related cognitive impairment. The aim was to study the 24-hour profiles of melatonin and cortisol in relation to cognitive function in middle-aged male subjects. Fifty healthy middle-aged males born in 1953 were recruited from a population-based cohort based on previous cognitive assessments in young adulthood and late midlife. The sample included 24 cognitively high-functioning and 26 cognitively impaired participants. Saliva samples were collected every 4 hours over a 24-hour period and analyzed for cortisol and melatonin levels by immunoassay. All participants exhibited clear circadian rhythms of salivary melatonin and cortisol. Salivary melatonin concentrations had a nocturnal peak at approximately 4 am. The median nocturnal melatonin response at 4 am was significantly lower in the cognitively impaired group than in the high-functioning group (−4.6 pg/mL, 95% CI: −7.84, −1.36, P=0.006). The 24-hour mean melatonin concentration (high-functioning group: 4.80±0.70 pg/mL, vs cognitively impaired group: 4.81±0.76 pg/mL; P>0.05) (or the area under the curve, AUC) was not significantly different between the two groups. Cortisol levels were low during the night, and peaked at approximately 8 am. Median cortisol concentrations were similar at all times, as were the 24-hour mean cortisol concentrations and AUC. To the best of our knowledge, ours is the first study to assess circadian measures (ie, melatonin and cortisol) in healthy middle-aged men with different cognitive trajectories in midlife. We found evidence of altered circadian rhythms with a reduced nocturnal melatonin response at 4 am in men with cognitive impairment. The 24-hour concentration and AUC of melatonin and cortisol were similar in the cognitively high-functioning group and in the cognitively impaired. Keywords: diurnal variation, middle-aged males, minimal cognitive impairmentWaller KLMortensen ELAvlund KOsler MFagerlund BLauritzen MGammeltoft SJennum PDove Medical PressarticleCircadian rhythmmelatonincortisolcognitive decline.PsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2016, Iss Issue 1, Pp 47-53 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Circadian rhythm melatonin cortisol cognitive decline. Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Circadian rhythm melatonin cortisol cognitive decline. Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Waller KL Mortensen EL Avlund K Osler M Fagerlund B Lauritzen M Gammeltoft S Jennum P Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition
description	Katja Linda Waller,1,2 Erik Lykke Mortensen,2,3 Kirsten Avlund,2,3,&dagger;, Merete Osler,3,4 Birgitte Fagerlund,5 Martin Lauritzen,2,6 Steen Gammeltoft,7 Poul Jennum1,2 1Danish Center for Sleep Medicine, Clinic of Clinical Neurophysiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; 2Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; 3Department of Public Health, University of Copenhagen, Copenhagen, Denmark; 4Research Center for Prevention and Health, Rigshospitalet, Glostrup, Denmark; 5Center for Neuropsychiatric Schizophrenia Research (CNSR), Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Glostrup, Denmark; 6Department of Clinical Neurophysiology, Rigshospitalet, Glostrup, Denmark; 7Department of Clinical Biochemistry, Rigshospitalet, Glostrup, Denmark &dagger;Kirsten Avlund passed away on June 15, 2012 Abstract: Previous studies have reported an association between circadian disturbances and age-related cognitive impairment. The aim was to study the 24-hour profiles of melatonin and cortisol in relation to cognitive function in middle-aged male subjects. Fifty healthy middle-aged males born in 1953 were recruited from a population-based cohort based on previous cognitive assessments in young adulthood and late midlife. The sample included 24 cognitively high-functioning and 26 cognitively impaired participants. Saliva samples were collected every 4 hours over a 24-hour period and analyzed for cortisol and melatonin levels by immunoassay. All participants exhibited clear circadian rhythms of salivary melatonin and cortisol. Salivary melatonin concentrations had a nocturnal peak at approximately 4 am. The median nocturnal melatonin response at 4 am was significantly lower in the cognitively impaired group than in the high-functioning group (−4.6 pg/mL, 95% CI: −7.84, −1.36, P=0.006). The 24-hour mean melatonin concentration (high-functioning group: 4.80±0.70 pg/mL, vs cognitively impaired group: 4.81±0.76 pg/mL; P>0.05) (or the area under the curve, AUC) was not significantly different between the two groups. Cortisol levels were low during the night, and peaked at approximately 8 am. Median cortisol concentrations were similar at all times, as were the 24-hour mean cortisol concentrations and AUC. To the best of our knowledge, ours is the first study to assess circadian measures (ie, melatonin and cortisol) in healthy middle-aged men with different cognitive trajectories in midlife. We found evidence of altered circadian rhythms with a reduced nocturnal melatonin response at 4 am in men with cognitive impairment. The 24-hour concentration and AUC of melatonin and cortisol were similar in the cognitively high-functioning group and in the cognitively impaired. Keywords: diurnal variation, middle-aged males, minimal cognitive impairment
format	article
author	Waller KL Mortensen EL Avlund K Osler M Fagerlund B Lauritzen M Gammeltoft S Jennum P
author_facet	Waller KL Mortensen EL Avlund K Osler M Fagerlund B Lauritzen M Gammeltoft S Jennum P
author_sort	Waller KL
title	Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition
title_short	Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition
title_full	Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition
title_fullStr	Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition
title_full_unstemmed	Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition
title_sort	melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/1e9d585a291b46f5b1af36dc4fc28b45
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_version_	1718403242288742400

Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition

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