Risk of thrombotic events after respiratory infection requiring hospitalization

Abstract Thrombosis is a major concern in respiratory infections. Our aim was to investigate the magnitude and duration of risk for arterial and venous thrombosis following discharge after respiratory infection. Patients with respiratory infections were identified using the United States Nationwide...

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Autores principales:	Nathaniel R. Smilowitz, Varun Subashchandran, Jonathan Newman, Michael E. Barfield, Thomas S. Maldonado, Shari B. Brosnahan, Eugene Yuriditsky, James M. Horowitz, Binita Shah, Harmony R. Reynolds, Judith S. Hochman, Jeffrey S. Berger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ea458ef53dc4f9a8a2ac9e1dccf5772
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spelling	oai:doaj.org-article:1ea458ef53dc4f9a8a2ac9e1dccf57722021-12-02T10:54:24ZRisk of thrombotic events after respiratory infection requiring hospitalization10.1038/s41598-021-83466-92045-2322https://doaj.org/article/1ea458ef53dc4f9a8a2ac9e1dccf57722021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83466-9https://doaj.org/toc/2045-2322Abstract Thrombosis is a major concern in respiratory infections. Our aim was to investigate the magnitude and duration of risk for arterial and venous thrombosis following discharge after respiratory infection. Patients with respiratory infections were identified using the United States Nationwide Readmission Database from 2012 to 2014. Patients admitted with asthma or cellulitis served as comparators. Readmissions for acute myocardial infarction (MI) and venous thromboembolism (VTE) were evaluated at 30 to 180 days. The likelihood of a first thrombotic event after discharge was compared with a 30-day period prior to hospitalization. Among 5,271,068 patients discharged after a respiratory infection, 0.56% and 0.78% were readmitted within 30-days with MI and VTE, respectively. Relative to asthma and cellulitis, respiratory infection was associated with a greater age and sex-adjusted hazard of 30-day readmission for MI (adjusted HR [aHR] 1.48 [95% CI 1.42–1.54] vs. asthma; aHR 1.36 [95% CI 1.31–1.41] vs. cellulitis) and VTE (aHR 1.28 [95% CI 1.24–1.33] vs. asthma; aHR 1.26, [95% CI 1.22–1.30] vs. cellulitis). Risks of MI and VTE attenuated over time. In a crossover-cohort analysis, the odds of MI (OR 1.68 [95% CI 1.62–1.73]) and VTE (OR 3.30 [95% 3.19–3.41]) were higher in the 30 days following discharge after respiratory infection than during the 30-day baseline period. Hospitalization for respiratory infection was associated with increased risks of thrombosis that were highest in the first 30-days after discharge and declined over time.Nathaniel R. SmilowitzVarun SubashchandranJonathan NewmanMichael E. BarfieldThomas S. MaldonadoShari B. BrosnahanEugene YuriditskyJames M. HorowitzBinita ShahHarmony R. ReynoldsJudith S. HochmanJeffrey S. BergerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nathaniel R. Smilowitz Varun Subashchandran Jonathan Newman Michael E. Barfield Thomas S. Maldonado Shari B. Brosnahan Eugene Yuriditsky James M. Horowitz Binita Shah Harmony R. Reynolds Judith S. Hochman Jeffrey S. Berger Risk of thrombotic events after respiratory infection requiring hospitalization
description	Abstract Thrombosis is a major concern in respiratory infections. Our aim was to investigate the magnitude and duration of risk for arterial and venous thrombosis following discharge after respiratory infection. Patients with respiratory infections were identified using the United States Nationwide Readmission Database from 2012 to 2014. Patients admitted with asthma or cellulitis served as comparators. Readmissions for acute myocardial infarction (MI) and venous thromboembolism (VTE) were evaluated at 30 to 180 days. The likelihood of a first thrombotic event after discharge was compared with a 30-day period prior to hospitalization. Among 5,271,068 patients discharged after a respiratory infection, 0.56% and 0.78% were readmitted within 30-days with MI and VTE, respectively. Relative to asthma and cellulitis, respiratory infection was associated with a greater age and sex-adjusted hazard of 30-day readmission for MI (adjusted HR [aHR] 1.48 [95% CI 1.42–1.54] vs. asthma; aHR 1.36 [95% CI 1.31–1.41] vs. cellulitis) and VTE (aHR 1.28 [95% CI 1.24–1.33] vs. asthma; aHR 1.26, [95% CI 1.22–1.30] vs. cellulitis). Risks of MI and VTE attenuated over time. In a crossover-cohort analysis, the odds of MI (OR 1.68 [95% CI 1.62–1.73]) and VTE (OR 3.30 [95% 3.19–3.41]) were higher in the 30 days following discharge after respiratory infection than during the 30-day baseline period. Hospitalization for respiratory infection was associated with increased risks of thrombosis that were highest in the first 30-days after discharge and declined over time.
format	article
author	Nathaniel R. Smilowitz Varun Subashchandran Jonathan Newman Michael E. Barfield Thomas S. Maldonado Shari B. Brosnahan Eugene Yuriditsky James M. Horowitz Binita Shah Harmony R. Reynolds Judith S. Hochman Jeffrey S. Berger
author_facet	Nathaniel R. Smilowitz Varun Subashchandran Jonathan Newman Michael E. Barfield Thomas S. Maldonado Shari B. Brosnahan Eugene Yuriditsky James M. Horowitz Binita Shah Harmony R. Reynolds Judith S. Hochman Jeffrey S. Berger
author_sort	Nathaniel R. Smilowitz
title	Risk of thrombotic events after respiratory infection requiring hospitalization
title_short	Risk of thrombotic events after respiratory infection requiring hospitalization
title_full	Risk of thrombotic events after respiratory infection requiring hospitalization
title_fullStr	Risk of thrombotic events after respiratory infection requiring hospitalization
title_full_unstemmed	Risk of thrombotic events after respiratory infection requiring hospitalization
title_sort	risk of thrombotic events after respiratory infection requiring hospitalization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ea458ef53dc4f9a8a2ac9e1dccf5772
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_version_	1718396455986659328

Risk of thrombotic events after respiratory infection requiring hospitalization

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