Drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets

In this review we discuss ten promising biological targets of interest for treating type 2 diabetes mellitus, obesity and metabolic syndrome. Namely, we address current experimental and clinical data on several new compounds that affect SGLT2, 11b-HSD1, PTP1B, SCD1, Il-1?. , fructose-1,6-bisphosphat...

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Autores principales:	Ivan Nikolaevich Tyurenkov, Denis Vladimirovich Kurkin, Elena Vladimirovna Volotova, Dmitriy Alexandrovich Bakulin, Elena Michailovna Lomkina
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	diabetes mellitus drug discovery sglt2 incretins gpr40 gpr119 11b-hsd1 ptp1b scd1 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/1ea5f94d47de4358a5e6e75c2d440579
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spelling	oai:doaj.org-article:1ea5f94d47de4358a5e6e75c2d4405792021-11-14T09:00:19ZDrug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets2072-03512072-037810.14341/DM20151101-109https://doaj.org/article/1ea5f94d47de4358a5e6e75c2d4405792015-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6835https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378In this review we discuss ten promising biological targets of interest for treating type 2 diabetes mellitus, obesity and metabolic syndrome. Namely, we address current experimental and clinical data on several new compounds that affect SGLT2, 11b-HSD1, PTP1B, SCD1, Il-1?. , fructose-1,6-bisphosphatase, glycogen phosphorylase, SIRT1, DGAT-1 and GPR119. The body of data shows potential of these substances to become effective antidiabetic agents.Ivan Nikolaevich TyurenkovDenis Vladimirovich KurkinElena Vladimirovna VolotovaDmitriy Alexandrovich BakulinElena Michailovna LomkinaEndocrinology Research Centrearticlediabetes mellitusdrug discoverysglt2incretinsgpr40gpr11911b-hsd1ptp1bscd1Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 1, Pp 101-109 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus drug discovery sglt2 incretins gpr40 gpr119 11b-hsd1 ptp1b scd1 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus drug discovery sglt2 incretins gpr40 gpr119 11b-hsd1 ptp1b scd1 Nutritional diseases. Deficiency diseases RC620-627 Ivan Nikolaevich Tyurenkov Denis Vladimirovich Kurkin Elena Vladimirovna Volotova Dmitriy Alexandrovich Bakulin Elena Michailovna Lomkina Drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets
description	In this review we discuss ten promising biological targets of interest for treating type 2 diabetes mellitus, obesity and metabolic syndrome. Namely, we address current experimental and clinical data on several new compounds that affect SGLT2, 11b-HSD1, PTP1B, SCD1, Il-1?. , fructose-1,6-bisphosphatase, glycogen phosphorylase, SIRT1, DGAT-1 and GPR119. The body of data shows potential of these substances to become effective antidiabetic agents.
format	article
author	Ivan Nikolaevich Tyurenkov Denis Vladimirovich Kurkin Elena Vladimirovna Volotova Dmitriy Alexandrovich Bakulin Elena Michailovna Lomkina
author_facet	Ivan Nikolaevich Tyurenkov Denis Vladimirovich Kurkin Elena Vladimirovna Volotova Dmitriy Alexandrovich Bakulin Elena Michailovna Lomkina
author_sort	Ivan Nikolaevich Tyurenkov
title	Drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets
title_short	Drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets
title_full	Drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets
title_fullStr	Drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets
title_full_unstemmed	Drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets
title_sort	drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/1ea5f94d47de4358a5e6e75c2d440579
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Drug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targets

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