Characteristics and outcome of critically ill patients with 2009 H1N1 influenza infection in Syria
Objectives: To describe the epidemiologic characteristics, clinical features, and outcome of severe cases of 2009 H1N1 influenza A infections who were admitted to the intensive care units (ICUs) in Damascus, Syria. Materials and Methods: Retrospectively, we collected clinical data on all patients wh...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2012
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oai:doaj.org-article:1ea6b2a1398f425aa188047dd1dff0672021-12-02T17:59:10ZCharacteristics and outcome of critically ill patients with 2009 H1N1 influenza infection in Syria2231-07702249-446410.4103/2231-0770.99156https://doaj.org/article/1ea6b2a1398f425aa188047dd1dff0672012-04-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.99156https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Objectives: To describe the epidemiologic characteristics, clinical features, and outcome of severe cases of 2009 H1N1 influenza A infections who were admitted to the intensive care units (ICUs) in Damascus, Syria. Materials and Methods: Retrospectively, we collected clinical data on all patients who were admitted to the ICU with confirmed or suspected diagnosis of severe 2009 H1N1 influenza A with respiratory failure at 4 major tertiary care hospitals in Damascus, Syria. Acute Physiology and Chronic Health Evaluation (APACHE) II system was used to assess the severity of illness within the first 24 h after admission. The outcome was overall hospital mortality. Results: Eighty patients were admitted to the ICU with severe 2009 H1N1 infection. The mean age was 40.7 years; 69.8% of patients had ≥1 of the risk factors: asthmatics 20%, obesity 23.8%, and pregnancy 5%; and 72.5% had acute lung injury or adult respiratory distress syndrome, 12.5% had viral pneumonia, 42.5% had secondary bacterial pneumonia, and 15% had exacerbation of airflow disease. Mechanical ventilation was required in 73.7% of cases. The mean hospital length of stay was 11.7 days (median 8 days, range 0-77 days, IQR: 5-14 days). The overall mortality rate was 51% for a mean APACHE II score of 15.2 with a predicted mortality of 21% (standardized mortality ratio of 2.4, 95% confidence interval: 1.7-3.2, P value < 0.001). Conclusion: Critically ill patients with severe 2009 H1N1 infection in this limited resource country had a much higher mortality rate than the predicted APACHE II mortality rate or when compared with the reported mortality rates for severe cases in other countries during 2009 H1N1 pandemic.Reem AlsadatAbdulrahman DakakMouna MazloomsGhasan GhadhbanShadi FattoomIbrahim BetelmalNabil AbouchalaMazen KherallahThieme Medical and Scientific Publishers Pvt. Ltd.articleadult respiratory distress syndromeh1n1pandemicsyriaMedicineRENAvicenna Journal of Medicine, Vol 02, Iss 02, Pp 34-37 (2012) |
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adult respiratory distress syndrome h1n1 pandemic syria Medicine R |
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adult respiratory distress syndrome h1n1 pandemic syria Medicine R Reem Alsadat Abdulrahman Dakak Mouna Mazlooms Ghasan Ghadhban Shadi Fattoom Ibrahim Betelmal Nabil Abouchala Mazen Kherallah Characteristics and outcome of critically ill patients with 2009 H1N1 influenza infection in Syria |
| description |
Objectives: To describe the epidemiologic characteristics, clinical features, and outcome of severe cases of 2009 H1N1 influenza A infections who were admitted to the intensive care units (ICUs) in Damascus, Syria. Materials and Methods: Retrospectively, we collected clinical data on all patients who were admitted to the ICU with confirmed or suspected diagnosis of severe 2009 H1N1 influenza A with respiratory failure at 4 major tertiary care hospitals in Damascus, Syria. Acute Physiology and Chronic Health Evaluation (APACHE) II system was used to assess the severity of illness within the first 24 h after admission. The outcome was overall hospital mortality. Results: Eighty patients were admitted to the ICU with severe 2009 H1N1 infection. The mean age was 40.7 years; 69.8% of patients had ≥1 of the risk factors: asthmatics 20%, obesity 23.8%, and pregnancy 5%; and 72.5% had acute lung injury or adult respiratory distress syndrome, 12.5% had viral pneumonia, 42.5% had secondary bacterial pneumonia, and 15% had exacerbation of airflow disease. Mechanical ventilation was required in 73.7% of cases. The mean hospital length of stay was 11.7 days (median 8 days, range 0-77 days, IQR: 5-14 days). The overall mortality rate was 51% for a mean APACHE II score of 15.2 with a predicted mortality of 21% (standardized mortality ratio of 2.4, 95% confidence interval: 1.7-3.2, P value < 0.001). Conclusion: Critically ill patients with severe 2009 H1N1 infection in this limited resource country had a much higher mortality rate than the predicted APACHE II mortality rate or when compared with the reported mortality rates for severe cases in other countries during 2009 H1N1 pandemic. |
| format |
article |
| author |
Reem Alsadat Abdulrahman Dakak Mouna Mazlooms Ghasan Ghadhban Shadi Fattoom Ibrahim Betelmal Nabil Abouchala Mazen Kherallah |
| author_facet |
Reem Alsadat Abdulrahman Dakak Mouna Mazlooms Ghasan Ghadhban Shadi Fattoom Ibrahim Betelmal Nabil Abouchala Mazen Kherallah |
| author_sort |
Reem Alsadat |
| title |
Characteristics and outcome of critically ill patients with 2009 H1N1 influenza infection in Syria |
| title_short |
Characteristics and outcome of critically ill patients with 2009 H1N1 influenza infection in Syria |
| title_full |
Characteristics and outcome of critically ill patients with 2009 H1N1 influenza infection in Syria |
| title_fullStr |
Characteristics and outcome of critically ill patients with 2009 H1N1 influenza infection in Syria |
| title_full_unstemmed |
Characteristics and outcome of critically ill patients with 2009 H1N1 influenza infection in Syria |
| title_sort |
characteristics and outcome of critically ill patients with 2009 h1n1 influenza infection in syria |
| publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
| publishDate |
2012 |
| url |
https://doaj.org/article/1ea6b2a1398f425aa188047dd1dff067 |
| work_keys_str_mv |
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