Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors
Hippocampal synaptic dysfunctions are an early symptom of Alzheimer’s disease. Here, the authors find adenosine A2A receptors are up-regulated in APP/PS1 model mice and that deleting or blocking receptor activity helps alleviate plasticity and memory impairments.
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Nature Portfolio
2016
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oai:doaj.org-article:1ea75979789f4071b6f94deca86c19df2021-12-02T16:58:00ZEarly synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors10.1038/ncomms119152041-1723https://doaj.org/article/1ea75979789f4071b6f94deca86c19df2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11915https://doaj.org/toc/2041-1723Hippocampal synaptic dysfunctions are an early symptom of Alzheimer’s disease. Here, the authors find adenosine A2A receptors are up-regulated in APP/PS1 model mice and that deleting or blocking receptor activity helps alleviate plasticity and memory impairments.Silvia Viana da SilvaMatthias Georg HaberlPei ZhangPhilipp BethgeCristina LemosNélio GonçalvesAdam GorlewiczMeryl MalezieuxFrancisco Q. GonçalvesNoëlle GrosjeanChristophe BlanchetAndreas FrickU Valentin NägerlRodrigo A. CunhaChristophe MulleNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Silvia Viana da Silva Matthias Georg Haberl Pei Zhang Philipp Bethge Cristina Lemos Nélio Gonçalves Adam Gorlewicz Meryl Malezieux Francisco Q. Gonçalves Noëlle Grosjean Christophe Blanchet Andreas Frick U Valentin Nägerl Rodrigo A. Cunha Christophe Mulle Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors |
| description |
Hippocampal synaptic dysfunctions are an early symptom of Alzheimer’s disease. Here, the authors find adenosine A2A receptors are up-regulated in APP/PS1 model mice and that deleting or blocking receptor activity helps alleviate plasticity and memory impairments. |
| format |
article |
| author |
Silvia Viana da Silva Matthias Georg Haberl Pei Zhang Philipp Bethge Cristina Lemos Nélio Gonçalves Adam Gorlewicz Meryl Malezieux Francisco Q. Gonçalves Noëlle Grosjean Christophe Blanchet Andreas Frick U Valentin Nägerl Rodrigo A. Cunha Christophe Mulle |
| author_facet |
Silvia Viana da Silva Matthias Georg Haberl Pei Zhang Philipp Bethge Cristina Lemos Nélio Gonçalves Adam Gorlewicz Meryl Malezieux Francisco Q. Gonçalves Noëlle Grosjean Christophe Blanchet Andreas Frick U Valentin Nägerl Rodrigo A. Cunha Christophe Mulle |
| author_sort |
Silvia Viana da Silva |
| title |
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors |
| title_short |
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors |
| title_full |
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors |
| title_fullStr |
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors |
| title_full_unstemmed |
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors |
| title_sort |
early synaptic deficits in the app/ps1 mouse model of alzheimer’s disease involve neuronal adenosine a2a receptors |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/1ea75979789f4071b6f94deca86c19df |
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