A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.
Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely u...
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2014
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oai:doaj.org-article:1ea87065669d488c9ed87c88a72fdbf92021-11-18T05:53:07ZA novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.1553-734X1553-735810.1371/journal.pcbi.1003493https://doaj.org/article/1ea87065669d488c9ed87c88a72fdbf92014-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586139/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo.Frederick A MatsenChristopher T SmallKhanh SolivenGregory A EngelMostafa M FeerozXiaoxing WangKaren L CraigM Kamrul HasanMichael EmermanMaxine L LinialLisa Jones-EngelPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 10, Iss 2, p e1003493 (2014) |
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DOAJ |
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| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Frederick A Matsen Christopher T Small Khanh Soliven Gregory A Engel Mostafa M Feeroz Xiaoxing Wang Karen L Craig M Kamrul Hasan Michael Emerman Maxine L Linial Lisa Jones-Engel A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses. |
| description |
Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo. |
| format |
article |
| author |
Frederick A Matsen Christopher T Small Khanh Soliven Gregory A Engel Mostafa M Feeroz Xiaoxing Wang Karen L Craig M Kamrul Hasan Michael Emerman Maxine L Linial Lisa Jones-Engel |
| author_facet |
Frederick A Matsen Christopher T Small Khanh Soliven Gregory A Engel Mostafa M Feeroz Xiaoxing Wang Karen L Craig M Kamrul Hasan Michael Emerman Maxine L Linial Lisa Jones-Engel |
| author_sort |
Frederick A Matsen |
| title |
A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses. |
| title_short |
A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses. |
| title_full |
A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses. |
| title_fullStr |
A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses. |
| title_full_unstemmed |
A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses. |
| title_sort |
novel bayesian method for detection of apobec3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/1ea87065669d488c9ed87c88a72fdbf9 |
| work_keys_str_mv |
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1718424652362022912 |