Inhibited growth of Pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles

Qi Wang,1 J Manuel Perez,2 Thomas J Webster1,3 1Bioengineering Program, College of Engineering, Northeastern University, Boston, MA, USA; 2Nanoscience Technology Center, University of Central Florida, Orlando, FL, USA; 3Department of Chemical Engineering, College of Engineering, Northeastern Univers...

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Autores principales:	Wang Q, Perez JM, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1ea871d8ee764c82948dca97986ace37
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spelling	oai:doaj.org-article:1ea871d8ee764c82948dca97986ace372021-12-02T07:28:29ZInhibited growth of Pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles1176-91141178-2013https://doaj.org/article/1ea871d8ee764c82948dca97986ace372013-08-01T00:00:00Zhttp://www.dovepress.com/inhibited-growth-of-pseudomonas-aeruginosa-by-dextran--and-polyacrylic-a14211https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Qi Wang,1 J Manuel Perez,2 Thomas J Webster1,3 1Bioengineering Program, College of Engineering, Northeastern University, Boston, MA, USA; 2Nanoscience Technology Center, University of Central Florida, Orlando, FL, USA; 3Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, USA Abstract: Ceria (CeO2) nanoparticles have been widely studied for numerous applications, but only a few recent studies have investigated their potential applications in medicine. Moreover, there have been almost no studies focusing on their possible antibacterial properties, despite the fact that such nanoparticles may reduce reactive oxygen species. In this study, we coated CeO2 nanoparticles with dextran or polyacrylic acid (PAA) because of their enhanced biocompatibility properties, minimized toxicity, and reduced clearance by the immune system. For the first time, the coated CeO2 nanoparticles were tested in bacterial assays involving Pseudomonas aeruginosa, one of the most significant bacteria responsible for infecting numerous medical devices. The results showed that CeO2 nanoparticles with either coating significantly inhibited the growth of Pseudomonas aeruginosa, by up to 55.14%, after 24 hours compared with controls (no particles). The inhibition of bacterial growth was concentration dependent. In summary, this study revealed, for the first time, that the characterized dextran- and PAA-coated CeO2 nanoparticles could be potential novel materials for numerous antibacterial applications. Keywords: antibacterial, biomedical applicationsWang QPerez JMWebster TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 3395-3399 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wang Q Perez JM Webster TJ Inhibited growth of Pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles
description	Qi Wang,1 J Manuel Perez,2 Thomas J Webster1,3 1Bioengineering Program, College of Engineering, Northeastern University, Boston, MA, USA; 2Nanoscience Technology Center, University of Central Florida, Orlando, FL, USA; 3Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, USA Abstract: Ceria (CeO2) nanoparticles have been widely studied for numerous applications, but only a few recent studies have investigated their potential applications in medicine. Moreover, there have been almost no studies focusing on their possible antibacterial properties, despite the fact that such nanoparticles may reduce reactive oxygen species. In this study, we coated CeO2 nanoparticles with dextran or polyacrylic acid (PAA) because of their enhanced biocompatibility properties, minimized toxicity, and reduced clearance by the immune system. For the first time, the coated CeO2 nanoparticles were tested in bacterial assays involving Pseudomonas aeruginosa, one of the most significant bacteria responsible for infecting numerous medical devices. The results showed that CeO2 nanoparticles with either coating significantly inhibited the growth of Pseudomonas aeruginosa, by up to 55.14%, after 24 hours compared with controls (no particles). The inhibition of bacterial growth was concentration dependent. In summary, this study revealed, for the first time, that the characterized dextran- and PAA-coated CeO2 nanoparticles could be potential novel materials for numerous antibacterial applications. Keywords: antibacterial, biomedical applications
format	article
author	Wang Q Perez JM Webster TJ
author_facet	Wang Q Perez JM Webster TJ
author_sort	Wang Q
title	Inhibited growth of Pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles
title_short	Inhibited growth of Pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles
title_full	Inhibited growth of Pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles
title_fullStr	Inhibited growth of Pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles
title_full_unstemmed	Inhibited growth of Pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles
title_sort	inhibited growth of pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/1ea871d8ee764c82948dca97986ace37
work_keys_str_mv	AT wangq inhibitedgrowthofpseudomonasaeruginosabydextranandpolyacrylicacidcoatedceriananoparticles AT perezjm inhibitedgrowthofpseudomonasaeruginosabydextranandpolyacrylicacidcoatedceriananoparticles AT webstertj inhibitedgrowthofpseudomonasaeruginosabydextranandpolyacrylicacidcoatedceriananoparticles
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Inhibited growth of Pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles

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