Diverse processing underlying frequency integration in midbrain neurons of barn owls.

Emergent response properties of sensory neurons depend on circuit connectivity and somatodendritic processing. Neurons of the barn owl's external nucleus of the inferior colliculus (ICx) display emergence of spatial selectivity. These neurons use interaural time difference (ITD) as a cue for th...

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Autores principales:	Julia C Gorman, Oliver L Tufte, Anna V R Miller, William M DeBello, José L Peña, Brian J Fischer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1eb06f4b4ec64b33ade7c879c0ca99e8
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spelling	oai:doaj.org-article:1eb06f4b4ec64b33ade7c879c0ca99e82021-12-02T19:58:11ZDiverse processing underlying frequency integration in midbrain neurons of barn owls.1553-734X1553-735810.1371/journal.pcbi.1009569https://doaj.org/article/1eb06f4b4ec64b33ade7c879c0ca99e82021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009569https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Emergent response properties of sensory neurons depend on circuit connectivity and somatodendritic processing. Neurons of the barn owl's external nucleus of the inferior colliculus (ICx) display emergence of spatial selectivity. These neurons use interaural time difference (ITD) as a cue for the horizontal direction of sound sources. ITD is detected by upstream brainstem neurons with narrow frequency tuning, resulting in spatially ambiguous responses. This spatial ambiguity is resolved by ICx neurons integrating inputs over frequency, a relevant processing in sound localization across species. Previous models have predicted that ICx neurons function as point neurons that linearly integrate inputs across frequency. However, the complex dendritic trees and spines of ICx neurons raises the question of whether this prediction is accurate. Data from in vivo intracellular recordings of ICx neurons were used to address this question. Results revealed diverse frequency integration properties, where some ICx neurons showed responses consistent with the point neuron hypothesis and others with nonlinear dendritic integration. Modeling showed that varied connectivity patterns and forms of dendritic processing may underlie observed ICx neurons' frequency integration processing. These results corroborate the ability of neurons with complex dendritic trees to implement diverse linear and nonlinear integration of synaptic inputs, of relevance for adaptive coding and learning, and supporting a fundamental mechanism in sound localization.Julia C GormanOliver L TufteAnna V R MillerWilliam M DeBelloJosé L PeñaBrian J FischerPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 11, p e1009569 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Julia C Gorman Oliver L Tufte Anna V R Miller William M DeBello José L Peña Brian J Fischer Diverse processing underlying frequency integration in midbrain neurons of barn owls.
description	Emergent response properties of sensory neurons depend on circuit connectivity and somatodendritic processing. Neurons of the barn owl's external nucleus of the inferior colliculus (ICx) display emergence of spatial selectivity. These neurons use interaural time difference (ITD) as a cue for the horizontal direction of sound sources. ITD is detected by upstream brainstem neurons with narrow frequency tuning, resulting in spatially ambiguous responses. This spatial ambiguity is resolved by ICx neurons integrating inputs over frequency, a relevant processing in sound localization across species. Previous models have predicted that ICx neurons function as point neurons that linearly integrate inputs across frequency. However, the complex dendritic trees and spines of ICx neurons raises the question of whether this prediction is accurate. Data from in vivo intracellular recordings of ICx neurons were used to address this question. Results revealed diverse frequency integration properties, where some ICx neurons showed responses consistent with the point neuron hypothesis and others with nonlinear dendritic integration. Modeling showed that varied connectivity patterns and forms of dendritic processing may underlie observed ICx neurons' frequency integration processing. These results corroborate the ability of neurons with complex dendritic trees to implement diverse linear and nonlinear integration of synaptic inputs, of relevance for adaptive coding and learning, and supporting a fundamental mechanism in sound localization.
format	article
author	Julia C Gorman Oliver L Tufte Anna V R Miller William M DeBello José L Peña Brian J Fischer
author_facet	Julia C Gorman Oliver L Tufte Anna V R Miller William M DeBello José L Peña Brian J Fischer
author_sort	Julia C Gorman
title	Diverse processing underlying frequency integration in midbrain neurons of barn owls.
title_short	Diverse processing underlying frequency integration in midbrain neurons of barn owls.
title_full	Diverse processing underlying frequency integration in midbrain neurons of barn owls.
title_fullStr	Diverse processing underlying frequency integration in midbrain neurons of barn owls.
title_full_unstemmed	Diverse processing underlying frequency integration in midbrain neurons of barn owls.
title_sort	diverse processing underlying frequency integration in midbrain neurons of barn owls.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1eb06f4b4ec64b33ade7c879c0ca99e8
work_keys_str_mv	AT juliacgorman diverseprocessingunderlyingfrequencyintegrationinmidbrainneuronsofbarnowls AT oliverltufte diverseprocessingunderlyingfrequencyintegrationinmidbrainneuronsofbarnowls AT annavrmiller diverseprocessingunderlyingfrequencyintegrationinmidbrainneuronsofbarnowls AT williammdebello diverseprocessingunderlyingfrequencyintegrationinmidbrainneuronsofbarnowls AT joselpena diverseprocessingunderlyingfrequencyintegrationinmidbrainneuronsofbarnowls AT brianjfischer diverseprocessingunderlyingfrequencyintegrationinmidbrainneuronsofbarnowls
_version_	1718375766547234816

Diverse processing underlying frequency integration in midbrain neurons of barn owls.

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