Designed α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms

Amyloid proteins: Peptides prevent folding Small protein fragments called peptides can be designed to interfere with the folding of proteins in biofilms and disrupt biofilm formation. Valerie Daggett and colleagues at the University of Washington in Seattle, USA, focused their attention on a type of...

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Autores principales:	Alissa Bleem, Robyn Francisco, James D. Bryers, Valerie Daggett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/1eb34436a96347d2bc762b0d1988ba39
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spelling	oai:doaj.org-article:1eb34436a96347d2bc762b0d1988ba392021-12-02T15:10:33ZDesigned α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms10.1038/s41522-017-0025-22055-5008https://doaj.org/article/1eb34436a96347d2bc762b0d1988ba392017-07-01T00:00:00Zhttps://doi.org/10.1038/s41522-017-0025-2https://doaj.org/toc/2055-5008Amyloid proteins: Peptides prevent folding Small protein fragments called peptides can be designed to interfere with the folding of proteins in biofilms and disrupt biofilm formation. Valerie Daggett and colleagues at the University of Washington in Seattle, USA, focused their attention on a type of folded proteins called amyloids. Some amyloid proteins are well known for their role in neurodegenerative diseases, but others can protect biofilms from degradation, making them resistant to treatment or to removal from medical devices. The researchers made peptide molecules, composed of linked amino acids, that were designed to physically interfere with the folding processes that create amyloids in biofilms. These peptides were shown to inhibit amyloid formation in biofilms produced by Staphylococcus aureus bacteria, which cause many clinically significant infections. The results may offer a novel approach to combat biofilm formation.Alissa BleemRobyn FranciscoJames D. BryersValerie DaggettNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Alissa Bleem Robyn Francisco James D. Bryers Valerie Daggett Designed α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms
description	Amyloid proteins: Peptides prevent folding Small protein fragments called peptides can be designed to interfere with the folding of proteins in biofilms and disrupt biofilm formation. Valerie Daggett and colleagues at the University of Washington in Seattle, USA, focused their attention on a type of folded proteins called amyloids. Some amyloid proteins are well known for their role in neurodegenerative diseases, but others can protect biofilms from degradation, making them resistant to treatment or to removal from medical devices. The researchers made peptide molecules, composed of linked amino acids, that were designed to physically interfere with the folding processes that create amyloids in biofilms. These peptides were shown to inhibit amyloid formation in biofilms produced by Staphylococcus aureus bacteria, which cause many clinically significant infections. The results may offer a novel approach to combat biofilm formation.
format	article
author	Alissa Bleem Robyn Francisco James D. Bryers Valerie Daggett
author_facet	Alissa Bleem Robyn Francisco James D. Bryers Valerie Daggett
author_sort	Alissa Bleem
title	Designed α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms
title_short	Designed α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms
title_full	Designed α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms
title_fullStr	Designed α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms
title_full_unstemmed	Designed α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms
title_sort	designed α-sheet peptides suppress amyloid formation in staphylococcus aureus biofilms
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1eb34436a96347d2bc762b0d1988ba39
work_keys_str_mv	AT alissableem designedasheetpeptidessuppressamyloidformationinstaphylococcusaureusbiofilms AT robynfrancisco designedasheetpeptidessuppressamyloidformationinstaphylococcusaureusbiofilms AT jamesdbryers designedasheetpeptidessuppressamyloidformationinstaphylococcusaureusbiofilms AT valeriedaggett designedasheetpeptidessuppressamyloidformationinstaphylococcusaureusbiofilms
_version_	1718387677128032256

Designed α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms

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