Effect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction

BACKGROUND AND OBJECTIVE: According to high prevalence and mortality of ischemic heart disease, mention to treatment is important. Glucose–insulin–potassium (GIK) as an adjunctive treatment of ST segment elevation myocardial infarction (STEMI) has been suggested but its effects are controversial. Wh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M Hashemian, AR Vakili, A Akaberi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	glucose insulin potassium myocardial infarction c-reactive protein Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1eb8dbe5507a457b8b42d659bcd1d282
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1eb8dbe5507a457b8b42d659bcd1d282
record_format	dspace
spelling	oai:doaj.org-article:1eb8dbe5507a457b8b42d659bcd1d2822021-11-10T08:56:58ZEffect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction1561-41072251-7170https://doaj.org/article/1eb8dbe5507a457b8b42d659bcd1d2822011-11-01T00:00:00Zhttp://jbums.org/article-1-3924-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: According to high prevalence and mortality of ischemic heart disease, mention to treatment is important. Glucose–insulin–potassium (GIK) as an adjunctive treatment of ST segment elevation myocardial infarction (STEMI) has been suggested but its effects are controversial. Whereas C-reactive protein (CRP) has prognostic value, we aimed to evaluate the effect of GIK on Plasma concentrations of C-reactive protein in STEMI patients.METHODS: This randomized clinical trial enrolled 72 patients who had STEMI that were referred to Vaseie hospital of Sabzevar, Iran. Patients were categorized to two groups by block randomization and were treated with a high dose of GIK (25% glucose, 50 IU of soluble insulin per liter, and 80 m mol of potassium chloride per liter at 1 ml/kg/hour) (GIK group) or normal saline (control group) as adjunct to thrombolytic therapy. We analyzed Plasma concentrations of high-sensitivity C-reactive protein (CRP) at baseline and sequentially for 48 hours.FINDINGS: Baseline CRP)GIK=5.6±5.9,control=4.0±4.3mg/L, p=0.35 (were significantly increased to 3-fold at 48 hours in each group (GIK=16.8±2.2, control=15.5±3.2mg/L, p=0.17). There was no difference in plasma concentrations of CRP between GIK and control patients (p=0.24). Mean glucose level over 6 hours was higher in GIK group (212±13 mg/dL) than control group (142±46 mg/dL, p=0.006). CONCLUSION: In patients with acute myocardial infarction treated with streptokinase, glucose-insulin-potassium therapy offers no anti-inflammatory effect.M Hashemian,AR Vakili,A AkaberiBabol University of Medical Sciencesarticleglucoseinsulinpotassiummyocardial infarctionc-reactive proteinMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 6, Pp 45-51 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	glucose insulin potassium myocardial infarction c-reactive protein Medicine R Medicine (General) R5-920
spellingShingle	glucose insulin potassium myocardial infarction c-reactive protein Medicine R Medicine (General) R5-920 M Hashemian, AR Vakili, A Akaberi Effect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction
description	BACKGROUND AND OBJECTIVE: According to high prevalence and mortality of ischemic heart disease, mention to treatment is important. Glucose–insulin–potassium (GIK) as an adjunctive treatment of ST segment elevation myocardial infarction (STEMI) has been suggested but its effects are controversial. Whereas C-reactive protein (CRP) has prognostic value, we aimed to evaluate the effect of GIK on Plasma concentrations of C-reactive protein in STEMI patients.METHODS: This randomized clinical trial enrolled 72 patients who had STEMI that were referred to Vaseie hospital of Sabzevar, Iran. Patients were categorized to two groups by block randomization and were treated with a high dose of GIK (25% glucose, 50 IU of soluble insulin per liter, and 80 m mol of potassium chloride per liter at 1 ml/kg/hour) (GIK group) or normal saline (control group) as adjunct to thrombolytic therapy. We analyzed Plasma concentrations of high-sensitivity C-reactive protein (CRP) at baseline and sequentially for 48 hours.FINDINGS: Baseline CRP)GIK=5.6±5.9,control=4.0±4.3mg/L, p=0.35 (were significantly increased to 3-fold at 48 hours in each group (GIK=16.8±2.2, control=15.5±3.2mg/L, p=0.17). There was no difference in plasma concentrations of CRP between GIK and control patients (p=0.24). Mean glucose level over 6 hours was higher in GIK group (212±13 mg/dL) than control group (142±46 mg/dL, p=0.006). CONCLUSION: In patients with acute myocardial infarction treated with streptokinase, glucose-insulin-potassium therapy offers no anti-inflammatory effect.
format	article
author	M Hashemian, AR Vakili, A Akaberi
author_facet	M Hashemian, AR Vakili, A Akaberi
author_sort	M Hashemian,
title	Effect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction
title_short	Effect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction
title_full	Effect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction
title_fullStr	Effect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction
title_full_unstemmed	Effect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction
title_sort	effect of glucose–insulin–potassium on plasma concentrations of c - reactive protein in acute myocardial infarction
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/1eb8dbe5507a457b8b42d659bcd1d282
work_keys_str_mv	AT mhashemian effectofglucoseinsulinpotassiumonplasmaconcentrationsofcreactiveproteininacutemyocardialinfarction AT arvakili effectofglucoseinsulinpotassiumonplasmaconcentrationsofcreactiveproteininacutemyocardialinfarction AT aakaberi effectofglucoseinsulinpotassiumonplasmaconcentrationsofcreactiveproteininacutemyocardialinfarction
_version_	1718440262302171136

Effect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction

Ejemplares similares