Molecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease

Abstract Human echovirus 18 (E-18) is a member of the enterovirus B species. To date, sixteen full-length genome sequences of E-18 are available in the GenBank database. In this study, we describe the complete genomic characterization of two E-18 strains isolated in Yunnan, China. Pairwise compariso...

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Autores principales:	Haihao Zhang, Yilin Zhao, Hongbo Liu, Hao Sun, Xiaoqin Huang, Zhaoqing Yang, Shaohui Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ebab60117b34fb8bb68df4551e631d8
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spelling	oai:doaj.org-article:1ebab60117b34fb8bb68df4551e631d82021-12-02T11:40:59ZMolecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease10.1038/s41598-017-09038-y2045-2322https://doaj.org/article/1ebab60117b34fb8bb68df4551e631d82017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09038-yhttps://doaj.org/toc/2045-2322Abstract Human echovirus 18 (E-18) is a member of the enterovirus B species. To date, sixteen full-length genome sequences of E-18 are available in the GenBank database. In this study, we describe the complete genomic characterization of two E-18 strains isolated in Yunnan, China. Pairwise comparisons of the nucleotide sequences and the deduced amino acid sequences revealed that the two Yunnan E-18 strains had 87.5% nucleotide identity and 96.3–96.5% amino acid identity with the Chinese strain. Phylogenetic and bootscanning analyses revealed the two E-18 strains had the highest identity with other several EV-B serotypes than the other E-18 strains in the P3 coding region, especially, 3B region of the Swine Vesicular disease virus (SVDV) strain HK70, indicated that frequent intertypic recombination might have occurred in the two Yunnan strains. This study contributes the complete genome sequences of E-18 to the GenBank database and provides valuable information on the molecular epidemiology of E-18 in China.Haihao ZhangYilin ZhaoHongbo LiuHao SunXiaoqin HuangZhaoqing YangShaohui MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haihao Zhang Yilin Zhao Hongbo Liu Hao Sun Xiaoqin Huang Zhaoqing Yang Shaohui Ma Molecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease
description	Abstract Human echovirus 18 (E-18) is a member of the enterovirus B species. To date, sixteen full-length genome sequences of E-18 are available in the GenBank database. In this study, we describe the complete genomic characterization of two E-18 strains isolated in Yunnan, China. Pairwise comparisons of the nucleotide sequences and the deduced amino acid sequences revealed that the two Yunnan E-18 strains had 87.5% nucleotide identity and 96.3–96.5% amino acid identity with the Chinese strain. Phylogenetic and bootscanning analyses revealed the two E-18 strains had the highest identity with other several EV-B serotypes than the other E-18 strains in the P3 coding region, especially, 3B region of the Swine Vesicular disease virus (SVDV) strain HK70, indicated that frequent intertypic recombination might have occurred in the two Yunnan strains. This study contributes the complete genome sequences of E-18 to the GenBank database and provides valuable information on the molecular epidemiology of E-18 in China.
format	article
author	Haihao Zhang Yilin Zhao Hongbo Liu Hao Sun Xiaoqin Huang Zhaoqing Yang Shaohui Ma
author_facet	Haihao Zhang Yilin Zhao Hongbo Liu Hao Sun Xiaoqin Huang Zhaoqing Yang Shaohui Ma
author_sort	Haihao Zhang
title	Molecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease
title_short	Molecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease
title_full	Molecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease
title_fullStr	Molecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease
title_full_unstemmed	Molecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease
title_sort	molecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1ebab60117b34fb8bb68df4551e631d8
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Molecular characterization of two novel echovirus 18 recombinants associated with hand-foot-mouth disease

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