A viral dynamic model for treatment regimens with direct-acting antivirals for chronic hepatitis C infection.

A viral dynamic model for treatment regimens with direct-acting antivirals for chronic hepatitis C infection.

We propose an integrative, mechanistic model that integrates in vitro virology data, pharmacokinetics, and viral response to a combination regimen of a direct-acting antiviral (telaprevir, an HCV NS3-4A protease inhibitor) and peginterferon alfa-2a/ribavirin (PR) in patients with genotype 1 chronic...

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Detalles Bibliográficos
Autores principales: Bambang S Adiwijaya, Tara L Kieffer, Joshua Henshaw, Karen Eisenhauer, Holly Kimko, John J Alam, Robert S Kauffman, Varun Garg
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/1ebc60fb8b8d4ddcaf1eafea5ed2727d
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