Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

While genome-wide association studies have yielded thousands of trait-associated loci, identifying causal variants remains challenging. Here, the authors perform seven genomics assays in various cell types to prioritize genetic variants in the TNFAIP3 locus, and report high-priority variants within...

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Autores principales:	John P. Ray, Carl G. de Boer, Charles P. Fulco, Caleb A. Lareau, Masahiro Kanai, Jacob C. Ulirsch, Ryan Tewhey, Leif S. Ludwig, Steven K. Reilly, Drew T. Bergman, Jesse M. Engreitz, Robbyn Issner, Hilary K. Finucane, Eric S. Lander, Aviv Regev, Nir Hacohen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ebe14a757924ee7b684604e682e0db0
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spelling	oai:doaj.org-article:1ebe14a757924ee7b684604e682e0db02021-12-02T17:32:41ZPrioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features10.1038/s41467-020-15022-42041-1723https://doaj.org/article/1ebe14a757924ee7b684604e682e0db02020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15022-4https://doaj.org/toc/2041-1723While genome-wide association studies have yielded thousands of trait-associated loci, identifying causal variants remains challenging. Here, the authors perform seven genomics assays in various cell types to prioritize genetic variants in the TNFAIP3 locus, and report high-priority variants within disease-associated haplotypes.John P. RayCarl G. de BoerCharles P. FulcoCaleb A. LareauMasahiro KanaiJacob C. UlirschRyan TewheyLeif S. LudwigSteven K. ReillyDrew T. BergmanJesse M. EngreitzRobbyn IssnerHilary K. FinucaneEric S. LanderAviv RegevNir HacohenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John P. Ray Carl G. de Boer Charles P. Fulco Caleb A. Lareau Masahiro Kanai Jacob C. Ulirsch Ryan Tewhey Leif S. Ludwig Steven K. Reilly Drew T. Bergman Jesse M. Engreitz Robbyn Issner Hilary K. Finucane Eric S. Lander Aviv Regev Nir Hacohen Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features
description	While genome-wide association studies have yielded thousands of trait-associated loci, identifying causal variants remains challenging. Here, the authors perform seven genomics assays in various cell types to prioritize genetic variants in the TNFAIP3 locus, and report high-priority variants within disease-associated haplotypes.
format	article
author	John P. Ray Carl G. de Boer Charles P. Fulco Caleb A. Lareau Masahiro Kanai Jacob C. Ulirsch Ryan Tewhey Leif S. Ludwig Steven K. Reilly Drew T. Bergman Jesse M. Engreitz Robbyn Issner Hilary K. Finucane Eric S. Lander Aviv Regev Nir Hacohen
author_facet	John P. Ray Carl G. de Boer Charles P. Fulco Caleb A. Lareau Masahiro Kanai Jacob C. Ulirsch Ryan Tewhey Leif S. Ludwig Steven K. Reilly Drew T. Bergman Jesse M. Engreitz Robbyn Issner Hilary K. Finucane Eric S. Lander Aviv Regev Nir Hacohen
author_sort	John P. Ray
title	Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features
title_short	Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features
title_full	Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features
title_fullStr	Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features
title_full_unstemmed	Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features
title_sort	prioritizing disease and trait causal variants at the tnfaip3 locus using functional and genomic features
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1ebe14a757924ee7b684604e682e0db0
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Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

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