Treatment options and patient perspectives in the management of fibromyalgia: future trends

Kim LawsonBiomedical Research Centre, Sheffield Hallam University, Faculty of Health and Wellbeing, Sheffield, UKAbstract: Fibromyalgia (FM) is a common, complex, and difficult to treat chronic widespread pain disorder, which usually requires a multidisciplinary approach using both pharmacological a...

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Autor principal:	Kim Lawson
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1ebe2bb6c362452188fdf89c5b8268a5
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spelling	oai:doaj.org-article:1ebe2bb6c362452188fdf89c5b8268a52021-12-02T00:56:50ZTreatment options and patient perspectives in the management of fibromyalgia: future trends1176-63281178-2021https://doaj.org/article/1ebe2bb6c362452188fdf89c5b8268a52008-11-01T00:00:00Zhttp://www.dovepress.com/treatment-options-and-patient-perspectives-in-the-management-of-fibrom-a2577https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Kim LawsonBiomedical Research Centre, Sheffield Hallam University, Faculty of Health and Wellbeing, Sheffield, UKAbstract: Fibromyalgia (FM) is a common, complex, and difficult to treat chronic widespread pain disorder, which usually requires a multidisciplinary approach using both pharmacological and non-pharmacological (education and exercise) interventions. It is a condition of heightened generalized sensitization to sensory input presenting as a complex of symptoms including pain, sleep dysfunction, and fatigue, where the pathophysiology could include dysfunction of the central nervous system pain modulatory systems, dysfunction of the neuroendocrine system, and dysautonomia. A cyclic model of the pathophysiological processes is compatible with the interrelationship of primary symptoms and the array of postulated triggers associated with FM. Many of the molecular targets of current and emerging drugs used to treat FM have been focused to the management of discrete symptoms rather than the condition. Recently, drugs (eg, pregabalin, duloxetine, milnacipran, sodium oxybate) have been identified that demonstrate a multidimensional efficacy in this condition. Although the complexity of FM suggests that monotherapy, non-pharmacological or pharmacological, will not adequately address the condition, the outcomes from recent clinical trials are providing important clues for treatment guidelines, improved diagnosis, and condition-focused therapies.Keywords: fibromyalgia, pain, sleep dysfunction, fatigue, exercise, pharmacological treatments Kim LawsonDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 6, Pp 1059-1071 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kim Lawson Treatment options and patient perspectives in the management of fibromyalgia: future trends
description	Kim LawsonBiomedical Research Centre, Sheffield Hallam University, Faculty of Health and Wellbeing, Sheffield, UKAbstract: Fibromyalgia (FM) is a common, complex, and difficult to treat chronic widespread pain disorder, which usually requires a multidisciplinary approach using both pharmacological and non-pharmacological (education and exercise) interventions. It is a condition of heightened generalized sensitization to sensory input presenting as a complex of symptoms including pain, sleep dysfunction, and fatigue, where the pathophysiology could include dysfunction of the central nervous system pain modulatory systems, dysfunction of the neuroendocrine system, and dysautonomia. A cyclic model of the pathophysiological processes is compatible with the interrelationship of primary symptoms and the array of postulated triggers associated with FM. Many of the molecular targets of current and emerging drugs used to treat FM have been focused to the management of discrete symptoms rather than the condition. Recently, drugs (eg, pregabalin, duloxetine, milnacipran, sodium oxybate) have been identified that demonstrate a multidimensional efficacy in this condition. Although the complexity of FM suggests that monotherapy, non-pharmacological or pharmacological, will not adequately address the condition, the outcomes from recent clinical trials are providing important clues for treatment guidelines, improved diagnosis, and condition-focused therapies.Keywords: fibromyalgia, pain, sleep dysfunction, fatigue, exercise, pharmacological treatments
format	article
author	Kim Lawson
author_facet	Kim Lawson
author_sort	Kim Lawson
title	Treatment options and patient perspectives in the management of fibromyalgia: future trends
title_short	Treatment options and patient perspectives in the management of fibromyalgia: future trends
title_full	Treatment options and patient perspectives in the management of fibromyalgia: future trends
title_fullStr	Treatment options and patient perspectives in the management of fibromyalgia: future trends
title_full_unstemmed	Treatment options and patient perspectives in the management of fibromyalgia: future trends
title_sort	treatment options and patient perspectives in the management of fibromyalgia: future trends
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/1ebe2bb6c362452188fdf89c5b8268a5
work_keys_str_mv	AT kimlawson treatmentoptionsandpatientperspectivesinthemanagementoffibromyalgiafuturetrends
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Treatment options and patient perspectives in the management of fibromyalgia: future trends

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