Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

The tumour stroma has altered stiffness and matrix architecture compared to normal tissue, which favours proliferation, and invasion. Here, the authors find that the extracellular matrix produced by normal fibroblasts inhibits cancer cell proliferation through mechanosensitive downregulation of JMJD...

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Autores principales:	Riina Kaukonen, Anja Mai, Maria Georgiadou, Markku Saari, Nicola De Franceschi, Timo Betz, Harri Sihto, Sami Ventelä, Laura Elo, Eija Jokitalo, Jukka Westermarck, Pirkko-Liisa Kellokumpu-Lehtinen, Heikki Joensuu, Reidar Grenman, Johanna Ivaska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ebfc9741f164d8f95d19712978bfaf4
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spelling	oai:doaj.org-article:1ebfc9741f164d8f95d19712978bfaf42021-12-02T17:33:07ZNormal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription10.1038/ncomms122372041-1723https://doaj.org/article/1ebfc9741f164d8f95d19712978bfaf42016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12237https://doaj.org/toc/2041-1723The tumour stroma has altered stiffness and matrix architecture compared to normal tissue, which favours proliferation, and invasion. Here, the authors find that the extracellular matrix produced by normal fibroblasts inhibits cancer cell proliferation through mechanosensitive downregulation of JMJD1a.Riina KaukonenAnja MaiMaria GeorgiadouMarkku SaariNicola De FranceschiTimo BetzHarri SihtoSami VenteläLaura EloEija JokitaloJukka WestermarckPirkko-Liisa Kellokumpu-LehtinenHeikki JoensuuReidar GrenmanJohanna IvaskaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Riina Kaukonen Anja Mai Maria Georgiadou Markku Saari Nicola De Franceschi Timo Betz Harri Sihto Sami Ventelä Laura Elo Eija Jokitalo Jukka Westermarck Pirkko-Liisa Kellokumpu-Lehtinen Heikki Joensuu Reidar Grenman Johanna Ivaska Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription
description	The tumour stroma has altered stiffness and matrix architecture compared to normal tissue, which favours proliferation, and invasion. Here, the authors find that the extracellular matrix produced by normal fibroblasts inhibits cancer cell proliferation through mechanosensitive downregulation of JMJD1a.
format	article
author	Riina Kaukonen Anja Mai Maria Georgiadou Markku Saari Nicola De Franceschi Timo Betz Harri Sihto Sami Ventelä Laura Elo Eija Jokitalo Jukka Westermarck Pirkko-Liisa Kellokumpu-Lehtinen Heikki Joensuu Reidar Grenman Johanna Ivaska
author_facet	Riina Kaukonen Anja Mai Maria Georgiadou Markku Saari Nicola De Franceschi Timo Betz Harri Sihto Sami Ventelä Laura Elo Eija Jokitalo Jukka Westermarck Pirkko-Liisa Kellokumpu-Lehtinen Heikki Joensuu Reidar Grenman Johanna Ivaska
author_sort	Riina Kaukonen
title	Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription
title_short	Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription
title_full	Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription
title_fullStr	Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription
title_full_unstemmed	Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription
title_sort	normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of jmjd1a-mediated transcription
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1ebfc9741f164d8f95d19712978bfaf4
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Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

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