Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss

Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss

Abstract We have shown that both reactive oxygen species (ROS) and paxillin tyrosine phosphorylation regulate LPS-induced human lung endothelial permeability. Mitochondrial ROS (mtROS) is known to increase endothelial cell (EC) permeability which requires dynamic change in mitochondrial morphology,...

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Autores principales: Panfeng Fu, Yulia Epshtein, Ramaswamy Ramchandran, Joseph B. Mascarenhas, Anne E. Cress, Jeffrey Jacobson, Joe G. N. Garcia, Viswanathan Natarajan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/1ec0f4a987774551a8f0d88321e35000
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