ZZ-dependent regulation of p62/SQSTM1 in autophagy

ZZ-dependent regulation of p62/SQSTM1 in autophagy

The autophagic receptor p62 recognizes arginylated (Nt-R) substrates through its ZZ domain (p62ZZ). Here the authors identify a p62 auto regulatory mechanism and provide structural insights into the selective recognition of Nt-R by p62ZZ and further show that Nt-R binding stimulates p62 oligomerizat...

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Autores principales: Yi Zhang, Su Ran Mun, Juan F. Linares, JaeWoo Ahn, Christina G. Towers, Chang Hoon Ji, Brent E. Fitzwalter, Michael R. Holden, Wenyi Mi, Xiaobing Shi, Jorge Moscat, Andrew Thorburn, Maria T. Diaz-Meco, Yong Tae Kwon, Tatiana G. Kutateladze
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/1ec1cc89931246b3bb35b15275075a73
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spelling oai:doaj.org-article:1ec1cc89931246b3bb35b15275075a732021-12-02T15:33:38ZZZ-dependent regulation of p62/SQSTM1 in autophagy10.1038/s41467-018-06878-82041-1723https://doaj.org/article/1ec1cc89931246b3bb35b15275075a732018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06878-8https://doaj.org/toc/2041-1723The autophagic receptor p62 recognizes arginylated (Nt-R) substrates through its ZZ domain (p62ZZ). Here the authors identify a p62 auto regulatory mechanism and provide structural insights into the selective recognition of Nt-R by p62ZZ and further show that Nt-R binding stimulates p62 oligomerization and macroautophagy.Yi ZhangSu Ran MunJuan F. LinaresJaeWoo AhnChristina G. TowersChang Hoon JiBrent E. FitzwalterMichael R. HoldenWenyi MiXiaobing ShiJorge MoscatAndrew ThorburnMaria T. Diaz-MecoYong Tae KwonTatiana G. KutateladzeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yi Zhang
Su Ran Mun
Juan F. Linares
JaeWoo Ahn
Christina G. Towers
Chang Hoon Ji
Brent E. Fitzwalter
Michael R. Holden
Wenyi Mi
Xiaobing Shi
Jorge Moscat
Andrew Thorburn
Maria T. Diaz-Meco
Yong Tae Kwon
Tatiana G. Kutateladze
ZZ-dependent regulation of p62/SQSTM1 in autophagy
description The autophagic receptor p62 recognizes arginylated (Nt-R) substrates through its ZZ domain (p62ZZ). Here the authors identify a p62 auto regulatory mechanism and provide structural insights into the selective recognition of Nt-R by p62ZZ and further show that Nt-R binding stimulates p62 oligomerization and macroautophagy.
format article
author Yi Zhang
Su Ran Mun
Juan F. Linares
JaeWoo Ahn
Christina G. Towers
Chang Hoon Ji
Brent E. Fitzwalter
Michael R. Holden
Wenyi Mi
Xiaobing Shi
Jorge Moscat
Andrew Thorburn
Maria T. Diaz-Meco
Yong Tae Kwon
Tatiana G. Kutateladze
author_facet Yi Zhang
Su Ran Mun
Juan F. Linares
JaeWoo Ahn
Christina G. Towers
Chang Hoon Ji
Brent E. Fitzwalter
Michael R. Holden
Wenyi Mi
Xiaobing Shi
Jorge Moscat
Andrew Thorburn
Maria T. Diaz-Meco
Yong Tae Kwon
Tatiana G. Kutateladze
author_sort Yi Zhang
title ZZ-dependent regulation of p62/SQSTM1 in autophagy
title_short ZZ-dependent regulation of p62/SQSTM1 in autophagy
title_full ZZ-dependent regulation of p62/SQSTM1 in autophagy
title_fullStr ZZ-dependent regulation of p62/SQSTM1 in autophagy
title_full_unstemmed ZZ-dependent regulation of p62/SQSTM1 in autophagy
title_sort zz-dependent regulation of p62/sqstm1 in autophagy
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/1ec1cc89931246b3bb35b15275075a73
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